黄琴琴，女，副教授，硕士生导师
地址：郑州市大学路40号郑州大学医学科学院精准医学中心
邮箱：qqhuang@zzu.edu.cn
手机号：13693712391
学习及工作经历：
2018-至今：郑州大学医学科学院精准医学中心，纳米医学，副教授
2022-2023：Johns Hopkins University，School of Medicine，Department of Cell Engineering and Neurology，博士后
2021-2022：Indian university, Intelligent Systems Engineering，博士后
2016-2018：武汉大学药学院，微生物学，重点资助博士后/助理研究员
2011-2016：武汉大学物理科学与技术学院，1+4硕博连读，材料物理与化学
研究方向：
1.使用纳米技术进行人体外周血罕见细胞的捕获和鉴定；
2.基于功能化细胞膜的肿瘤靶向治疗；
3.神经退行性疾病研究。
主持或参加科研项目：
1. 国家自然科学基金青年科学基金，31800085，细菌DNA磷硫酰化修饰位点的特异性标记，2019/01-2021/12， 结题，主持；
2. 河南省教育厅/高层次人才国际化培养，基于循环肿瘤细胞的类器官培养用于个体化药物筛选，2022/01-2023/12，在研，主持；
3. 郑州大学第二附属医院拔尖人才项目，22180007，2020/01-2023/12，在研，主持；
4. 2019年度郑州大学青年骨干教师，纳米技术检测胎儿有核红细胞进行无创性产前诊断，2020/01-2021/12，结题，主持；
5. 郑州大学青年教师科研启动费（拔尖博士），2018-2020，结题，主持；
6. 2019 年度河南省医学科技攻关计划联合共建项目，应用孕妇外周血胎儿有核红细胞进行耳聋基因诊断，2020/01-2021/12，结题，主持
7. 中国博士后科学基金会，特别资助项目，2017T100571，基于微流控芯片的单细胞水平上DNA硫修饰的可视化捕捉，2018/01-2019/12，结题，主持；
8. 中国博士后科学基金会，面上项目，2016M602367，基于微流控芯片的帕金森病早期诊断及药物筛选研究，2017/01-2018/12，结题，主持；
9. 国家自然科学基金重大仪器专项，81527801，基于微流控芯片的全自动胎儿有核红细胞分析仪器，2016/01-2020/12，结题，参加；
10. 国家自然科学基金面上项目，81572860，基于纳米功能材料的循环肿瘤细胞转移研究，2016/01-2019/12，结题，参加。
代表性研究成果 （#共同一作，*通讯作者）
1. 第一作者和通讯作者论文
1. Shipeng Ning, Tianfu Zhang, Meng Lyu, Jacky Wing Yip Lam, Daoming Zhu*, Qinqin Huang*, Ben Zhong Tang*. A type I AIE photosensitiser-loaded biomimetic nanosystem allowing precise depletion of cancer stem cells and prevention of cancer recurrence after radiotherapy, Biomaterials, 2023, 122034. （中科院一区，IF=15.863）
2. Shile Wang, Yanyu Chen, Jiancheng Guo, Qinqin Huang*. Liposomes for Tumor Targeted Therapy: A Review, International Journal of Molecular Sciences, 2023, 24 (3), 2643.（中科院二区，IF=6.208）
3. Yanyu Chen, Zhuhao Wu, Joseph Sutlive, Ke Wu, Lu Mao, Jiabao Nie, Xing-Zhong Zhao, Feng Guo, Zi Chen, Qinqin Huang*. Noninvasive prenatal diagnosis targeting fetal nucleated red blood cells. Journal of Nanobiotechnology. 2023, 20(1), 546. （中科院一区，IF=9.2）
4. Qinqin Huang, Xingxiang Chen, Qian-Fang Meng, Ludan Yue, Wei Jiang, Xing-Zhong Zhao, Lang Rao, Xiaoyuan Chen, Shi Chen. Microfluidics-assisted fluorescence mapping of DNA phosphorothioation. Analytical Chemistry. 2022.（中科院一区，IF=8）
5. Xianjia Wu, Zhousheng Lin, Chenchen Zhao, Lujie Liu, Kelin Zhang, Jialin Lai, Qian-Fang Meng, Gaungyu Yao, Qinqin Huang*, Xing-Zhong Zhao, Lang Rao. Neutrophil membrane-coated immunomagnetic nanoparticles for efficient isolation and analysis of circulating tumor cells, Biosensors and Bioelectronics, 2022.（中科院一区，IF=12.545）
6. Tianfu Zhang, Zeming Liu, Wenxue Tang, Daoming Zhu, Meng Lyu, Jacky Wing Yip Lam, Qinqin Huang*, Ben Zhong Tang. Mitochondria-targeting Type I AIE photosensitizer combined with H2S therapy: Uninterrupted hydroxyl radical generation for enhancing tumor therapy, Nano Today, 2022.（中科院一区，IF=18.962）
7. Weihong Guo, Tao Wang, Chunyu Huang, Shipeng Ning, Qinglong Guo, Wei Zhang, Huawei Yang, Daoming Zhu, Qinqin Huang*, Haisheng Qian, Xianwen Wang. Platelet membrane-coated C-TiO2 hollow nanospheres for combined sonodynamic and alkyl-radical cancer therapy. Nano Research. 2022.（中科院一区，IF=10.269）
8. Zeming Liu, Ning Zeng, Jing Yu, Chunyu Huang, Qinqin Huang*. A novel dual MoS2/FeGA quantum dots endowed injectable hydrogel for efficient photothermal and boosting chemodynamic therapy. Frontiers in Bioengineering and Biotechnology, 2022.（中科院二区，IF=6.064）
9. Shuntao Wang, Qi Zhang, Mingzhu Chen, Ning Zeng, Qinqin Huang*. Nanozyme Hydrogels for Self-Augmented Sonodynamic/Photothermal Combination Therapy. Frontiers in Oncology, 2022. （中科院二区，IF=5.738）
10. Shuntao Wang, Qi Zhang, Ning Zeng, Pengyuan Qi, Chunyu Huang, Qinqin Huang*. Injectable Hydrogel System for Camptothecin Initiated Nanocatalytic Tumor Therapy With High Performance. Frontiers in Oncology, 2022.（中科院二区，IF=5.738）
11. Shu Zhu, Shuntao Wang, Chunping Liu, Meng Lyu, Qinqin Huang*. Cu-Hemin Nanosheets and Indocyanine Green Co-Loaded Hydrogel for Photothermal Therapy and Amplified Photodynamic Therapy. Frontiers in Oncology, 2022.（中科院二区，IF=5.738）
12. Shipeng Ning, Zeming Liu, Mingzhu Chen, Daoming Zhu, Qinqin Huang*. Nanozyme hydrogel for enhanced alkyl radical generation and potent antitumor therapy. Nanoscale Advances, 2022（中科院二区，IF=5.598）
13. Zeming Liu, Hongbo Chen, Chunyu Huang, Qinqin Huang*. A Light-Responsive Injectable Hydrogel with Remodeling Tumor Microenvironment for Light-Activated Chemodynamic Therapy. MACROMOLECULAR BIOSCIENCE. 2022.（中科院二区，IF=5.859）
14. Wenxue Tang, Xiang Li, Meng Lyu, Qinqin Huang*. Cancer Cell Membrane Biomimetic Mesoporous Nanozyme System with Efficient ROS Generation for Antitumor Chemoresistance. Oxidative Medicine and Cellular Longevity, 2022（中科院二区，IF=7.31）
15. Wenxue Tang, Xiang Li, Zeming Liu, Lyu Meng, Daoming Zhu, Qinqin Huang*. CuS nanoparticles and camptothecin co-loaded thermosensitive injectable hydrogel with self-supplied H2O2 for enhanced chemodynamic therapy, Frontiers in Bioengineering and Biotechnology, 2022.（中科院二区，IF=6.064）
16. Qinqin Huang, Meng Lyu, Wenxue Tang, Pengyuan Qi, Hongzhi Hu. Hydrogel co-loading SO2 prodrug and FeGA nanoparticles for enhancing chemodynamic therapy by photothermal-triggered SO2 gas therapy. Frontiers in Bioengineering and Biotechnology, 2022.（中科院二区，IF=6.064）
17. Daoming Zhu, Zeming Liu, Yang Li, Qinqin Huang*, Ligang Xia, and Kaiyang Li. Delivery of Manganese Carbonyl to the Tumor Microenvironment using Tumor-Derived Exosomes for Cancer Gas Therapy and Low Dose Radiotherapy, Biomaterials, 2021.（中科院一区，IF=15.479）
18. Wen Zeng, Dazhen Jiang, Zeming Liu, Weilong Suo, Ziqi Wang, Daoming Zhu, Qinqin Huang*. An injectable hydrogel for enhanced FeGA-based chemodynamic therapy by increasing intracellular acidity. Frontiers in Oncology, 2021.（中科院二区，IF=6.244）
19. Wen Zeng, Chunping Liu, Shuntao Wang, Ziqi Wang, Qinqin Huang*. SnFe2O4 nanozyme based TME improvement system for anti-cancer combination thermoradiotherapy. Frontiers in Oncology, 2021.（中科院二区，IF=6.244）
20. Miao Jiang; Shuiling Jin; Jinming Han; Tong Li; Jianxiang Shi; Qian Zhong; Wen Li, Wenxue Tang*, Qinqin Huang*, Hong Zong*. Detection and clinical significance of circulating tumor cells in colorectal cancer. Biomarker Research. 2021（中科院二区，IF=8.2）
21. Yue Wei#, Qinqin Huang#, Xihao Tian, Mingmin Zhang, Junkai He, Xingxiang Chen, Chao Chen, Zixin Deng, Zhiqiang Li, Shi Chen and Lianrong Wang. Single-molecule optical mapping of the distribution of DNA phosphorothioate epigenetics. Nucleic Acids Research, 2021, 49,(7), 3672–3680. （中科院一区，IF=18.971）
22. Chunyu Huang#; Tongkai Chen#; Daoming Zhu; Qinqin Huang*. Enhanced Tumor Targeting and Radiotherapy by Quercetin Loaded Biomimetic Nanoparticles, Frontiers in Chemistry, 2020, 8(225): 225-230. （中科院二区，IF=5.221）
23. Zhu Daoming#, Lyu Meng#, Jiang Wei#, Suo Meng, Huang Qinqin*, Li Kaiyang*, Biomimetic nanozymes/camptothecin hybrid system for synergistically enhanced Radiotherapy, Journal of Materials Chemistry B, 2020, 24(8): 5312-5319（中科院二区，，IF=6.331）
24. Daoming Zhu#, Meng Lyu#, Qinqin Huang#, Meng Suo, Ying Liu, Wei Jiang,* Yanhong Duo,*and Kelong Fan*. Stellate Plasmonic Exosomes for Penetrative Targeting Tumor NIR-II Thermo-Radiotherapy. ACS Appl. Mater. Interfaces 2020, 12, 36928−36937. （中科院一区，IF=10.229）
25. Huang Qinqin*, Chen Xingxiang, Jiang Wei, Jin Shuiling, Wang Xingyu, Liu Wei, Guo Shishang, Guo Jiancheng* and Zhao Xing-Zhong*. Sensitive and specific detection of circulating tumor cells promotes precision medicine for cancer. J Cancer Metastasis Treat. 2019; 5:34.
26. Huang Qinqin, Wang Fu-Bing, Yuan Chun-Hui, He Zhaobo, Rao Lang, Cai Bo, Chen Bolei, Jiang Susu, Li Zhiqiang, Chen Jincao, Liu Wei, Guo Feng, Ao Zheng, Chen Shi and Zhao Xing-Zhong. Gelatin Nanoparticle-Coated Silicon Beads for Density-Selective Capture and Release of Heterogeneous Circulating Tumor Cells with High Purity. Theranostics. 2018; 8(6): 1624-1635. （中科院一区，IF=11.556）
27. Huang Qinqin, Wang Yin, Chen Xingxiang, Wang Yimeng, Li Zzhiqiang, Du Siming, Wang Liangrong, Chen Shi. Nanotechnology-Based Strategies for Early Cancer Diagnosis Using Circulating Tumor Cells as a Liquid Biopsy. Nanotheranostics. 2018; 2(1):21-41.（中科院二区，IF=5）
28. Huang Qinqin, Cai Bo, Chen Bolei, Rao Lang, He Zhaobo, He Rongxiang, Guo Feng, Zhao Libo, Kondamareddy Kiran Kumar, Liu Wei*, Guo Shishang*, Zhao Xing-Zhong*. Efficient Purification and Release of Circulating Tumor Cells by Synergistic Effect of Biomarker and SiO2@Gel-Microbead-Based Size Difference Amplification. Advanced Healthcare Materials. 2016, 5(13): 1554-1559. （中科院一区，IF=11.933）
29. Huang Qinqin, Chen Bolei, He Rongxiang, He Zhaobo, Cai Bo, Xu Junhua, Qian Weiyi, Chan Helen Laiwa, Liu Wei*, Guo Shishang*, Zhao Xing-Zhong*, Yuan Jikang*. Capture and release of cancer cells based on sacrificeable transparent MnO2 nanospheres thin film. Advanced Healthcare Materials. 2014, 3(9): 1420-1425.（中科院一区，IF=11.933）
2. 非第一作者论文
1. Rao Lang, Meng Qian-Fang, Huang, Qinqin, Wang, Zixiang, Yu, Guang-Tao, Li, Andrew, Ma, Weijie, Zhang, Nangang, Guo, Shi-Shang, Zhao, Xing-Zhong, Liu, Kan, Yuan, Yufeng, Liu, Wei.Platelet-Leukocyte Hybrid Membrane-Coated Immunomagnetic Beads for Highly Efficient and Highly Specific Isolation of Circulating Tumor Cells. Advanced Functional Materials.2018, 28(34): 1803531-1803539（IF=13.325）
2. Rao Lang, Meng Qian-Fang, Huang Qinqin, Liu Pei, Bu Lin-Lin, Kondamareddy Kiran Kumar, Guo Shi-Shang, Wei Liu, Zhao Xing-Zhong. Photocatalytic Degradation of Cell Membrane Coatings for Controlled Drug Release. Advanced Healthcare Materials. 2016, 5, 1420-1427. （IF：5.1）
3. Cai Bo, He Rongxiang, Yu Xiaolei, Rao Lang, He Zhaobo, Huang Qinqin, Zhao Xing-Zhong. 3D Valve-based Controllable PDMS Nozzle for Dynamic Modulation of Droplet Generation. Microfluidics and Nanofluidics. 2016, 20, 1-10. （IF：2.3）
4. Rao Lang, Cai Bo, Wang Jieli, Meng Qianfang, Ma Chi, He Zhao Bo, Xu Junhua, Huang Qinqin, Li Shasha, Chen Yi, Guo ShiShang, Liu Wei, Zhao Xing-Zhong. A microfluidic electrostatic separator based on pre-charged droplets. Sensors and Actuators B- Chemical. 2015, 210, 328-335. （IF：5.4）
5. Liu Huiqin, Yu Xiaolei, Cai Bo, You Sujian, He Zhaobo, Huang Qinqin, Rao Lang, Li Shasha, Liu Chang, Sun Weiwei, Liu Wei, Guo Shishang, Zhao Xing-Zhong. Capture and release of cancer cells using electrospun etchable MnO2 nanofibers intergrated in microchannels. Applied Physics Letters. 2015, 106, 093703. （IF：3.302）
6. Rao Lang, Bu Lin-Lin, Xu Jun-Hua, Cai Bo, Yu Guang-Tao, Yu Xiaolei, He Zhaobo, Huang Qinqin, Li Andrew, Guo Shi-Shang, Zhang Wen-Feng, Liu Wei, Sun Zhi-Jun, Wang Hao, Wang Tza-Huei, Zhao Xing-Zhong. Red Blood Cell Membrane as a Biomimetic Nanocoating for Prolonged Circulation Tome and Reduced Accelerated Blood Clearance. Small. 2015, 11, 6225-6236.（IF：10.368）
7. He Zhaobo, Guo Feng, Feng Chun, Cai Bo, Lata James P, He Rongxiang, Huang Qinqin, Yu Xiaolei, Rao Lang, Liu Huiqin, Guo Shishang, Liu Wei, Zhang Yuanzhen, Huang TonyJun, Zhao Xingzhong, Fetal nucleated red blood cell analysis for non-invasive prenatal diagnostics using a nanostructure microchip. Journal of Materials Chemistry B. 2017, 5, 226-235.（IF=5.2）
8. Rao Lang, Meng Qian-Fang, Bu Lin-Lin, Cai Bo, Huang Qinqin, Sun Zhi-Jun, Zhang Wen-Feng, Li Andrew, Guo Shi-Shang, Liu Wei, Wang Tza-Huei, Zhao Xing-Zhong, Erythrocyte Membrane-Coated Upconversion Nanoparticles with Minimal Protein Adsorption for Enhanced Tumor Imaging. ACS applied materials & interfaces. 2017, 9, 2159-2168.（SCI一区，IF=8.2）
9. Wei, Xiaoyun, Ao, Zheng, Cheng, Lin, He, Zhaobo, Huang, Qinqin, Cai, Bo, Rao, Lang, Meng, Qianfang, Wang, Zixiang, Sung, Yue, Liu, Wei, Zhang, Yuanzhen, Guo, Shishang, Guo, Feng, Zhao, Xing-Zhong, Highly sensitive and rapid isolation of fetal nucleated red blood cells with microbead-based selective sedimentation for non-invasive prenatal diagnostics. Nanotechnology. 2018, 29(43).（IF=3.2）
