Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography
【作者】Qianhua Feng, Yuanyuan Zhang, Wanxia Zhang, Xiaoning Shan, Yujie Yuan, Hongling Zhang, Lin Hou,Zhenzhong Zhang
【期刊名】 Acta Biomaterialia
【影响因子】 2016年:6.319
【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, China
【年，卷(期)：页码】2016, 38: 129–142
【关键词】 Hyaluronic acid; Hollow mesoporous copper sulfide; Tumor-targeted; Theranostics; Multi-stimuli responsive
【摘要】In this work, a tumor-targeted and multi-stimuli responsive drug delivery system has been developed forcombining photoacoustic tomography imaging withchemo-phototherapy. We utilized a kind of nearinfrared (NIR) resonant material-hollow mesoporous copper sulfide nanoparticles (HMCuS NPs) to encapsulatedoxorubicin (DOX). After that, the outer surface of HMCuS NPs was capped with multifunctionalhyaluronic acid (HA) simultaneously as smart gatekeeper as well as tumor targeting moiety. Herein,HMCuS-HA could serve as a powerful contrast agent for photoacoustic tomography (PAT) to guidechemo-phototherapy by providing the identification of cancerous lesions. In vitro and in vivo studies,the nanoplatform (DOX/HMCuS-HA) pinpointed MCF-7 cells via CD44 receptor-mediated endocytosispathway. Subsequently, intracellular enzyme-responsive controlled drug release would take place inlysosome after the HA degradation by hyaluronidase. Under near infrared (NIR) light irradiation,HMCuS NPs could not only effectively convert NIR light into heat for photothermal therapy, but also generatehigh levels of reactive oxygen species (ROS) for photodynamic therapy. In addition, NIR light andlow pH environment could facilitate intracellular tunable drug release with spatial/temporal resolution,and thus synergistic combination of chemo-phototherapy should be simultaneously driven by an 808 nmlaser irradiation, which brought out an outstanding therapeutic effect. In vivo optical imaging demonstrated that HMCuS-HA significantly enhanced targeting and accumulation capacity in tumor site. Furthermore, tumor-bearing mice treated with DOX/HMCuS-HA under NIR irradiation (808 nm, 2W/cm2, 0.5 min) in vivo displayed the highest inhibition ratio of about 88.9%. Taken together, our presentstudy of the tumor-targeted and multi-stimuli responsive drug delivery system provides new insightsinto multimodality theranostic applications in cancer treatment.
【全文链接】
https://www.sciencedirect.com/science/article/pii/S1742706116301787
