Programmed near-infrared light-responsive drug delivery system for combined magnetic tumor-targeting magnetic resonance imaging and chemo-phototherapy

【作者】 Qianhua Feng, Yuanyuan Zhang, Wanxia Zhang, Yongwei Hao, Yongchao Wang, Hongling Zhang, Lin Hou,Zhenzhong Zhang

【期刊名】 Acta Biomaterialia

【影响因子】 2017年:6.383

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, China

【年，卷(期)：页码】2017, 49: 402–413

【关键词】 Hollow mesoporous copper sulfide; Magnetic targeting; Controlled release; Theranostics

【摘要】In this study, an intelligent drug delivery system was developed by capping doxorubicin (DOX)-loadedhollow mesoporous CuS nanoparticles (HMCuS NPs) with superparamagnetic iron oxide nanoparticles(IONPs). Under near infrared (NIR) light irradiation, the versatile HMCuS NPs could exploit the meritsof both photothermal therapy (PTT) and photodynamic therapy (PDT) simultaneously. Herein, the multifunctionalIONPs as gatekeeper with the enhanced capping efficiency were supposed to realize ‘‘zeropremature release” and minimize the adverse side effects during the drug delivery in vivo. More importantly,the hybrid metal nanoplatform (HMCuS/DOX@IONP-PEG) allowed several emerging exceptionalcharacteristics. Our studies have substantiated the hybrid nanoparticles possessed an enhanced PTTeffect due to coupled plasmonic resonances with an elevated heat-generating capacity. Notably, an effectiveremoval of IONP-caps occurred after NIR-induced photo-hyperthermia via weakening of the coordinationinteractions between HMCuS-NH2 and IONPs, which suggested the feasibility of sophisticatedcontrolled on-demand drug release upon exposing to NIR stimulus with spatial/temporal resolution.Benefiting from the favorable magnetic tumor targeting efficacy, the in vitro and in vivo experiments indicateda remarkable anti-tumor therapeutic efficacy under NIR irradiation, resulting from the synergisticcombination of chemo-phototherapy. In addition, T2-weighted magnetic resonance imaging (MRI) contrastperformance of IONPs provided the identification of cancerous lesions. Based on these findings,the well-designed drug delivery system via integration of programmed functions will provide knowledgefor advancing multimodality theranostic strategy.

【全文链接】

https://www.sciencedirect.com/science/article/pii/S1742706116306316