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    杜 斌

    2017-10-15   点击:[]

       

    郑州大学药学院教授,硕士生导师。郑州大学教学名师,河南省新型药物制剂研究团队、河南省药物分析重点学科骨干成员,河南省药学会药物分析专业委员会委员,国际权威刊物 Journal of luminscence”等权威期刊审稿专家。主要研究方向:1、药物微载体转运系统的构建;2、疾病早期标志物检测系统研究。参与国家纳米科技专项1项,国家自然基金项目4项,主持和参与河南省科技攻关项目8项,市科技局创新团队项目1项,科技攻关项目5项;发表学术论文40余篇,其中以第一或通讯作者,在国际权威期刊上发表SCI/EI收录论文30余篇,其中SmallNanoscaleJCR一区论文6篇;授权国家发明专利2项。

    联系方式:dubin@zzu.edu.cn、电话:0371-67781891

    工作与教育经历:

    2010/12 - 至今,郑州大学,药学院,教授

    (期间2012/02 –2014/10,吉林大学,药学院,博士后)

    2003/12 –2010/11,郑州大学,药学院,副教授

    2007/09 - 2010/06,郑州大学,药物化学,博士

    2001/09 - 2004/06,郑州大学,分析化学,硕士

    1985/09 - 1989/06,河南大学,化学,学士

    社会兼职:

    河南省生物物理学会 理事

    河南省药学会药物分析专业委员会 委员

    荣誉称号及奖励:

    2013 郑州大学教学名师

    专著与教材:

    杜斌(主编),《实用现代色谱技术》,郑州大学出版社,2009

    药物分析(参编),《药物分析》,科学出版社,2007年

    主持或参加研究项目:

    1.河南省科技攻关项目,52110131,“铁蛋白笼”多模式成像肿瘤诊疗一体化纳米平台的构建,2015/01-2016/12,在研,主持。

    2.国家自然科学基金面上项目,81273451,多机制治疗肿瘤光热控释长循环转运系统的研究,2013/01-2016/12,在研,参加。

    3.科技创新团队项目,121PCXTD521,纳米药物制剂的研制,2012/06-2015/06,已完成,主持。

    国家发明专利:

    1. 杜斌,朱玲,张振中,赵娅,王舒雨,赵芝兰,2-甲氧基雌二醇纳米混悬剂冻干粉及其制备方法,授权,ZL 2009 1 0065461.6

    2. 杜斌,韩淑萍,赵飞飞,苏相洁,王宇辉,一种近红外激光触发的复合纳米制剂的制备方法,公开,CN201510432200.9

    学术论文:

    1. Feifei Zhao, Jie Zhou, Xiangjie Su, Yuhui Wang, Xiaosa Yan, Shaona Jia, Bin Du*. A smart responsive dual aptamers-targeted bubble-generating nanosystem for cancer triplex therapy and ultrasound imaging. Small, 2017 online(一区)

    2. Xiangjie Su, Feifei Zhao, Yuhui Wang, Xiaosa Yan, Shaona Jia, Bin Du*. CuS as a gatekeeper of mesoporous upconversion nanoparticles-based drug controlled release system for tumor-targeted multimodal imaging and synergetic chemo- thermotherapy. Nanomedicine-Nanotechnology Biology and Medicine, 2017, 13(5):1761-1772(一区)

    3. Bin Du, Shuping Han, Hongyan Li, Feifei Zhao, Xiangji Su, Zhenzhong Zhang*. Multi-functional liposomes having radiofrequency-triggered release and magnetic resonance imaging for tumor multi-mechanism therapy. Nanoscale, 2015, 7: 5411-5426(一区)

    4. Bin Du, Shuping Han, Feifei Zhao, Kok Hwa Lim, Hongwei Xi, Xiangjie Su, Hanchun Yao*, Jie Zhou*. A smart upconversion-based light-triggered polymer for synergetic chemo-photodynamic therapy and dual-modal MR/UCL imaging. Nanomedicine-Nanotechnology Biology and Medicine, 2016, 12: 2071-2080(一区)

    5. Bin DuXiaohui CaoFeifei ZhaoXiangjie SuYuhui WangXiaosa YanShaona JiaJie Zhou*Hanchun Yao*. Multimodal imaging-guided, dual-targeted photothermal therapy for cancer. Journal of Materials Chemistry B, 2016, 4: 2038-2050(一区)

    6. Bin Du, iantian Qu, Zheng Chen, Xiaohui Cao, Shuping Han, Guopeng Shen*, Lei Wang. A novel restricted access material combined to molecularly imprinted polymers for selective solid-phase extraction and high performance liquid chromatography determination of 2-methoxyestradiol in plasma samples. Talanta, 2014, 129 : 465-472(一区)

    7. Bin DuTiantian WangShuping HanXiaohui CaoTiantian QuFeifei ZhaoGuo, Xinhong, Hanchun Yao*. Determination of 2-methoxyestradiol by chemiluminescence based on luminol-KMnO4-CdTe quantum dots system. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy201536 : 149-154 (二区)

    8. Bin Du, Ying Li, Xiaotian Li, Youmei A, Chengqun Chen, Zhenzhong Zhang*. Preparation, characterization and in vivo evaluation of 2-methoxyestradiol-loaded liposomesInternational Journal of Pharmaceutics, 2010, 384 : 140-147(二区)

    9. Bin Du, Li Pang, Hongyan Li, Sijia Ma, Yang Li, Xin Jia, Zhenzhong Zhang*. Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of indapamide enantiomers in rats. Journal of Chromatography B, 2013, 932: 88-91(二区)

    10. Bin Du, Li PangYanhua YangGuopeng ShenZhenzhong Zhang*. Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of pioglitazone enantiomers in rats. Journal of Chromatography B, 2014, 951:143-148(二区)

    11. Bin DuHongyan LiJianwen JinTiantian WangYang LiGuopeng Shen*, Xiaotian Li*. Chemiluminescence determination of streptomycin in pharmaceutical preparation and its application to pharmacokinetic study by a flow injection analysis assembly. Spectrochimica Acta A2013115 : 823-828 (二区)

    12. Bin DuShuyu WangXiufang ShiChaofeng ZhangZhenzhong Zhang*. The effect of 2-methoxyestradiol liposome on growth inhibition, angiogenesis and expression of VEGF and Ki67 in mice bearing H22 hepatocellular carcinoma.   Tumori201197: 660-665

    13. Bin DuZhilan ZhaoHuibin SunSijia MaJianwen JinZhenzhong Zhang*. Effects of 2-methoxyestradiol on proliferation, apoptosis and gene expression of cyclin B1 and c-Myc in esophageal carcinoma EC9706 cells. Cell Biochemistry and Function2012, 30 : 158-165

    14. Guopeng ShenQingyu WangQingqing ZhangHuibin SunYa ZhaoZhenzhong Zhang*, Bin Du*. Tissue distribution of 2-methoxyestradiol nanosuspension in rats and its antitumor activity in C57BL/6 mice bearing lewis    lung carcinoma. Drug Delivery201219 : 327-333 (二区)

    15. Shuzhang DuLing ZhuBin Du*, Xiufang ShiZhenzhong Zhang*Chaofeng Zhang. Pharmacokinetic evaluation and antitumor activity of 2-methoxyestradiol nanosuspension. Drug Development and Industrial Pharmacy201238 : 431-438

    16. Jianwen JinHanchun YaoZheng ChenLi Pang, Bin Du*. Flow injection chemiluminescence determination of 2-methoxyestradiol based on inhibition of luminol-potassium ferricyanide reaction. Luminescence201328:270-274

    17. Guopeng ShenXin JiaJianwen JinLi PangZheng Chen, Bin Du*. Determination of ferulic acid by flow injection chemiluminescence analysis based

    on enhancement of the N-bromobutanimide-eosin-CrCl3 system in alkaline solution. Luminescence201328 : 536-541

    18. Guopeng ShenXin JiaSijia MaTiantian Wang, Zhenzhong Zhang*, Bin Du*.

    Resolution of racemic gamma-substituted butenolide derivatives using a polysaccharide type stationary phase by high performance liquid chromatography. Journal of Liquid Chromatography & Related Technologies201437 : 841-849


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