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    张云

    2017-10-15   点击:[]


    张云

    郑州大学药学院特聘教授,药剂学学科骨干,积大制药首席科学官。从中国药科大学获得博士学位,曾在美国加州大学洛杉矶分校先后从事博士后研究工作和任职助理教授,曾任美国Armagen Technologies Inc. 公司药理部主任,以及诺华上海研究中心肿瘤药理及转化医学研究室主任。多年来,一直从事新型药物转运系统及其在肿瘤治疗中的应用方面的研究工作,已有60多篇SCI论文发表在各种著名国际刊物上,如 PNAS, Molecular Therapy, Human Gene Therapy, The Journal of Gene TherapyJournal of Controlled Release, BiomaterialsPharmaceutical ResearchJournal of materials chemistry B等。曾主持完成三项美国NIH课题,四项中国国家自然科学基金课题。获得中国发明专利两项。

    联系方式:邮箱zhangyun@zzu.edu.cn、电话18601196725

    工作与教育经历:

    2007.01-至今,郑州大学,药学院药剂学系,特聘教授

    2015.09-至今,昆明积大制药股份有限公司,副总经理(分管研发)及首席科学官

    2008.10-2015.08,诺华制药上海研究中心,肿瘤药理及转化医学研究室主任

    2003.08-2008.09,美国Armagen Technologies, Inc.公司,科学家及药理部主任

    1999.10-2003.07,美国加州大学洛杉矶分校,医学院,博士后及助理教授

    1996.09-1999.06,中国药科大学,药学院,博士

    1993.07-1996.08,重庆医药工业研究院,药理研究室,助理工程师及工程师

    1990.09-1993.06,西南农业大学,农学系,硕士

    1986.09-1990.07,四川师范学院,生物系,学士


    社会兼职:

    荣誉称号及奖励:

    专著与教材:

    主持或参加研究项目:

    1. 国家自然科学基金面上项目, 30772543,新型免疫脂质体介导的双基因对实验性人肝癌的特异靶向性治疗研究,2008/01-2010/12,结题,主持。

    2. 国家自然科学基金面上项目, 30973482,siRNA干扰联合热疗的碳纳米管肝肿瘤靶向性和治疗研究,2010/01-2012/12,结题,主持。

    3. 国家自然科学基金面上项目, 81272527,脑肿瘤靶向治疗的新策略研究,2013/01-2016/12,结题,主持。

    4. 国家自然科学基金面上项目, 81572991,基于二氧化锰纳米层构建的多功能肿瘤靶向诊断治疗系统研究,2016/01-2019/12,在研,主持。


    国家发明专利:

    1. 任雪玲,张振中,柴丽娜,宋雨,张云,一种包含自剪切位点的组织特异性双基因沉默RNAi表达载体,授权,ZL201210033935.0.

    2. 王蕾,郝永伟,张云,赵亚林,孟德辉,李懂,史进进,张振中,一种基于聚乳酸-羟基乙酸共聚物的靶向共载药物传递系统纳米粒的制备方法及应用, 授权,ZL201310615647.0。


    学术论文:

    1. Yurong Hu, Kun Li, Lei Wang, Shasha Yin, Zhengzhong Zhang, Yun Zhang*. Pegylated immuno-lipopolyplexes: a novel non-viral gene delivery system for liver cancer therapy. Journal of Controlled Release, 2010, 144: 75-81.

    2. Yurong Hu, Xueling Ren, Hui Wang, Yue Ma, Lei Wang, Yingying Shen, Kazuhiro Oka, Zhenzhong Zhang, Yun Zhang*. Liver-specific expression of an exogenous gene controlled by human apolipoprotein A-I promoter. International Journal of Pharmaceutics,2010, 398: 161-164.

    3. Xueling Ren, Yue Ma, Min Xu, Tingting Chen, Zhenzhong Zhang, Yun Zhang*. Construction, modification and evaluation of apolipoprotein A-I promoter-driven shRNA expression vectors against hTERT. Plasmid, 2011, 65: 42-50.

    4. Yurong Hu, Yingying Shen, Baofang Ji, Shasha Yin, Xueling Ren, Tingting Chen, Yue Ma, Zhenzhong Zhang, Yun Zhang*. Liver-specific gene therapy of hepatocellular carcinoma by targeting human telomerase reverse ranscriptase with pegylated immuno-lipopolyplexes. European Journal of Pharmaceutics and Biopharmaceutics, 2011, 78: 320-325.

    5. Yurong Hu, Yingying Shen, Baofeng Ji, Lei Wang, Zhenzhong Zhang, Yun Zhang*. Combinational RNAi gene therapy of hepatocellular carcinoma by targeting human EGFR and TERT. European Journal of Pharmaceutical Sciences, 2011, 42: 387-392.

    6. Lei Wang, Jinjin Shi, Haixia Li, Hongling Zhang, Zhenzhong Zhang, Yun Zhang*. Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes. Biomaterials, 2013, 34: 262-274.

    7. Haixia Li, Nan Zhang, Yongwei Hao, Yali Wang, Shasha Jia, Hongling, Zhang, Yun Zhang*, Zhenzhong Zhang. Formulation of curcumin delivery with functionalized single-walled carbon nanotubes: characteristics and anticancer effects in vitro. Drug Delivery, 2014, 21: 379-387.

    8. Xinhong Guo, Rui Ding, Ying Zhang, Ling Ye, Xin Liu, Caiping Chen, Zhenzhong, Yun Zhang*. Dual role of photosensitizer and carrier material of fullerence in micelles for chemo-photodynamic therapy of cancer. Journal of Pharmaceutical Sciences, 2015, 103: 3225-3234.

    9. Xinhong Guo, Xinxin Zhang, Ling Ye, Ying Zhang, Rui Ding, Yongwei Hao, Yalin Zhao, Zhenzhong Zhang, Yun Zhang*. Inhalable microspheres embedding chitosan-coated PLGA nanoparticles for 2-methoxyestradiol. Journal of Drug Targeting, 2014, 22: 421-427.

    10. Lei Wang, Yongwei Hao, Haixia Li, Yalin Zhao, Dehui Meng, Dong Li, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang and Yun Zhang*. Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles. Journal of Drug Targeting, 2015, 23: 832-846.

    11. Yongwei Hao, Lei Wang, Yalin Zhao, Dehui Meng, Dong Li, Haixia Li, Bingxiang Zhang, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang and Yun Zhang*. Targeted Imaging and chemo-phototherapy of brain cancer by a multifunctional drug delivery system. Macromolecular Bioscience, 2015, 15: 1571-1585.

    12. Lei Wang, Dehui Meng, Yongwei Hao, Yalin Zhao, Dong Li, Bingxiang Zhang, Yun Zhang* and Zhenzhong Zhang. Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications. Journal of Biomaterials Applications, 2015, 30: 547-557.

    13. Yongwei Hao, Bingxiang Zhang, Cuixia Zheng, Rui Ji, Xiangyi Ren, Fangfang Guo, Shili Sun, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Lei Wang and Yun Zhang*. The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging.  Journal of Controlled Release, 2015, 220: 545-555.

    14. Haixia Li, Yongwei Hao, Ning Wang, Shasha Jia, Yali Wang, Lijia Yang, Yun Zhang* and Zhenzhong Zhang. DOTAP functionalizing single-walled carbon nanotubes as non-viral vectors for efficient intracellular siRNA delivery. Drug Delivery, 2016, 23: 840-848.

    15. Yongwei Hao, Lei Wang, Bingxiang Zhang, Hongjuan Zhao, MengYa Niu, Yujie Hu, Cuixia Zheng, Hongling Zhang, Junbiao Chang , Zhenzhong Zhang and Yun Zhang*. Multifunctional nanosheets based on folic acid modified manganese oxide for tumor targeting theranostic application. Nanotechnology, 2016, 27: 025101.

    16. Yongwei Hao, Lei Wang, Bingxiang Zhang, Dong Li, Dehui Meng, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang and Yun Zhang*. Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application. International Journal of Nanomedicine, 2016, 11: 1759-1778.

    17. Lei Wang, Dehui Meng, Yongwei Hao, Yujie Hu, Mengya Niu, Cuixia Zheng, Yanyan Yin, Dong Li, Panpan Zhang, Junbiao Chang, Zhenzhong Zhang and Yun Zhang*. A gold nanostar based multi-functional tumor-targeting nanoplatform for tumor theranostic applications. Journal of Material Chemistry B, 2016, 4: 5895-5906.

    18. Yongwei Hao, Bingxiang Zhang, Cuixia Zheng, Mengya Niu, Haochen Guo, Hongling Zhang, Junbiao Chang, Zhenzhong Zhang, Lei Wang and Yun Zhang*. Multifunctional nanoplatform for enhanced photodynamic cancer therapy and magnetic resonance imaging. Colloids and surfaces B: Bioinferfaces. 2017, 151: 384-393.

    19. Lei Wang, Dong Li, Yongwei Hao, Mengya Niu, Hongjuan Zhao, Yujie Hu, Cuixia Zheng, Junbiao Chang, Zhenzhong Zhang and Yun Zhang*. A gold nanorod based PLGA@MnO2 core-shell structured multi-functional nanoplatform for cancer theranostic applications. International Journal of Nanomedicine, 2017, 12: 3059-3075.

    20. Yongwei Hao, Bingxiang Zhang, Lei Wang, Dong Li, Dehui Meng, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang and Yun Zhang*. Covalent Self-Assembled Nanoparticles with pH-dependent Enhanced Tumor Retention and Drug Release for Improving Tumor Therapeutic Efficiency. Journal of Materials Chemistry B, 2017, 5: 2133-2144.


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