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    张振中

    2017-10-15   点击:[]


     张振中

    二级教授,博士生导师,药学院、药物研究院院长,新世纪“百千万人才工程”国家级人选,国家有突出贡献中青年专家,河南省优秀专家,河南省优秀教师,河南省生物物理学会副理事长,中国生物颗粒学会理事, 河南省药学会药分专业委员会副主任委员,河南省中青年骨干教师,河南省科技创新团队(药物新制剂)带头人,河南省杰出青年基金获得者,河南省杰出科技创新人才,国家人事部优秀留学回国人员,河南省高等学校创新人才培养对象,河南省高校杰出科研人才。

    多次参加教育部本科教学质量工程(精品课程、教学名师等),长江学者,国家青年千人计划等评审工作,教育部学位中心优秀博士、硕士论文评审工作等。

    主持国家自然科学基金6项、国家纳米科技专项1项等国家和省级项目。已发表研究论文300余篇,SCI收录220余篇,其中一区有20余篇(通讯作者17篇)(如Biomaterials, Nanoscale, Acta Biomaterial, J Controlled Release)和二区近20余篇(通讯作者) (Pharmaceutical Research, Int J Nanomed, J Pharm Pharm Sci)上;影响因子>5分的论文50余篇;以通讯作者发表的2篇论文进入世界前1%高被引论文郑州大学“药理毒理学科”ESI贡献率连续三年排名第1,“材料科学”连续两年第2。参编国家规划教材6部,参编专著1部(纳米毒理学,副主编)。申请专利61项,授权35项。河南省科技进步一等奖1项(第一名),二、三等奖6项,厅局级8项。

    联系方式:

    邮箱:zhenzhongz@126.com

    电话:0371-67781910

    工作与教育经历:

    2000.07-至今,郑州大学,药学院,教授

    2002.04-2003.04,瑞典卡洛琳斯卡医学院,博士后

    1996.07-2000.07,河南医科大学,药学系,副教授

    1996.09-1999.06,中国药科大学,药物分析,博士

    1990.07-1996.09,河南医科大学,公共卫生学院,讲师

    1987.09-1990.06,河南医科大学,卫生化学,硕士

    1983.09-1987.06,河南大学,化学,学士

    社会兼职:

    河南省生物物理学会副理事长

    中国生物颗粒学会理事

    河南省药学会药分专业委员会副主任委员

    河南省科技创新团队(药物新制剂)带头人

    荣誉称号及奖励:

    新世纪“百千万人才工程”国家级人选

    国家有突出贡献中青年专家

    河南省优秀专家

    河南省优秀教师

    河南省中青年骨干教师

    河南省杰出青年基金获得者

    河南省杰出科技创新人才

    国家人事部优秀留学回国人员

    河南省高等学校创新人才培养对象

    河南省高校杰出科研人才

    主持或参加研究项目:

    1. 国家自然科学基金面上项目,81573364,远程调控介孔门控型磁性载体多机制治疗肿瘤研究,2016/01-2019/12,在研,主持。

    2. 国家自然科学基金面上项目,81273451、多机制治疗肿瘤光热控释长循环转运系统的研究、2013/01-2016/12,已结题,主持。

    3. 国家自然科学基金面上项目,30973660,难溶性抗癌药物肿瘤靶向转运载体设计和热疗特性研究,2010/01-2012/12,已结题,主持。

    4. 河南省科技创新杰出人才,094200510002,国家一类抗肿瘤新药2-ME的研发,2009/01-2011/12,已结题,主持。

    5. 国家自然科学基金面上项目,30772671,具有自组装功能寡核苷酸的肿瘤靶向纳米转运系统研究,2008/01-2008/12,已结题,主持。

    6. 国家人事部优秀留学回国人员资助项目,具有肿瘤细胞靶向性的寡核苷酸转运系统,2004/01-2006/12,已结题,主持。

    7. 国家自然科学基金纳米科技专项,90406024,具有分子识别功能的核酸纳米转运系
    统研究,2006/01-2007/12,已结题,主持。

    8. 国家自然科学基金面上项目,30371695,具有肿瘤细胞靶向性的NGR-反义寡核苷酸超分子组装体研究,2004/01-2006/12,已结题,主持

    9. 河南省杰出青年基金,0112001100,反义核苷酸纳米粒的制备研究,2001/01-2003/12,已结题,主持

    10. 河南省高校杰出科研人才创新工程项目,2000CYX004,肺癌组织黑色素瘤抗原表达和基因克隆,2000/01-2002/12,已结题,主持

    国家发明专利:

    1. 王蕾,张振中,张云,李懂,郝永伟,张冰祥,牛梦亚,孟德辉,郑翠霞,赵红娟,胡玉洁,张红岭,一种包覆二氧化锰片层的聚乳酸-羟基乙酸共聚物的制备方法及应用,授权,ZL 2016 1 0276557.7

    2. 郭新红,张振中,陈彩萍,郭晓楠,侯盼盼,丁芳,刘欣,郭冀民, 一种口服胶束微球的制备方法及其应用,授权,ZL 2015 1 0893235.2

    3. 冯倩华,张振中,侯琳,张媛媛,张宛霞, 一种近红外光远程调控的介孔门控型硫化铜药物组合物的制备方法及其应用,授权,ZL 2016 1 0116240.7

    4. 祝侠丽,张振中,黄胜楠,谢莹霞,黄河清,张英杰,侯琳,李志,张慧娟,焦晓静, 一种主动靶向固体脂质纳米载体及其制备方法与应用,授权,ZL 2014 1 0004665.X

    5. 施秀芳,张振中,姚海峰,孙帅军,吴丹丹,景飞,路翔,李鹏, 2-甲氧基雌二醇类似物及其制备方法与用途,授权,ZL 2013 1 0753425.5

    6. 侯琳,单晓宁,张振中,冯倩华,郝丽莎,袁玉洁,王用超, 一种转铁蛋白修饰的中空介孔硫化铜/青蒿琥酯纳米粒的制备方法及其应用,授权,ZL 2015 1 0549228.0

    7. 张红岭,张慧娟,张振中,陈倩倩,张晓戈, 有抗肿瘤药物纳米层的透明质酸修饰的二氧化钛-氧化石墨烯复合材料制备方法及应用,授权,ZL 2015 1 0551231.6

    8. 施秀芳,王淙,张振中,高海英,孙帅军,路翔,王志豪,杨腾蛟,李鹏,王铭铭,杜昕芮,以雌甾为母核的2位或16位取代的查耳酮衍生物及其制备方法和用途, 授权, ZL 2015 1 0577322.7

    9. 侯琳,张振中,王用超,杨晓敏,张银玲,袁玉洁,张媛媛,单晓宁, 一种负载吲哚菁绿的自组装多功能纳米靶向系统的制备方法及其应用,授权,ZL 2015 1 0581283.8

    10. 李志,张振中,潘丽丽,张飞龙,祝侠丽,夏亚丹,闫淑娟, 一种可植入的富勒烯聚乳酸自团聚载药缓释微球的制备方法及应用,授权,ZL 2014 1 0006420.0

    11. 张红岭,史进进,张振中,刘艳,高君,马柔柔,张静,余晓媛,刘瑞瑗, 镧系金属负载富勒烯纳米材料水溶性衍生物的合成方法及其应用,授权, ZL 2013 1 0259356.2

    12. 李志, 张振中,潘丽丽,张飞龙,祝侠丽,夏亚丹,闫淑娟, 一种负载5-氨基乙酰丙酸的富勒烯水溶性衍生物的合成方法与应用,授权, ZL 2014 1 0005050.9

    13. 史进进, 张振中,马柔柔,刘瑞瑗,余晓媛,张静,高君,刘艳, 富勒烯-纳米金复合材料及其制备方法与应用,授权, ZL 2013 1 0260339.0

    14. 侯琳, 张振中,王丽丽,王亚婷,张慧娟,张红岭, 一种以透明质酸修饰的羧基化短单壁碳纳米管为载体的钆类造影剂及其制备方法和应用,授权, ZL 2013 1 0397793.0

    15. 侯琳, 张振中,蒋桂香,冯倩华,张红岭, 一种氧化石墨烯衍生物的制备方法与应用, 授权, ZL 2013 1 0397861.3

    16. 祝侠丽, 张振中,谢莹霞,黄胜楠,侯琳,张慧娟,王蕾,史进进,张英杰,黄河清, 一种隐形热敏脂质体的制备及其药物转运系统在肿瘤治疗药物中的应用,授权, ZL 2013 1 0494933.6

    17. 张振中,王蕾,史进进,高岩,李璐璐,张红岭, 一种水溶性碳纳米管及其制备应用方法,授权, ZL 2012 1 0220013.3

    18. 张红岭,史进进, 张振中,刘艳,叶凡,高君,刘瑞瑗,马柔柔,余晓媛,张静,王蕾,侯琳, 一种水溶性富勒烯及其应用,授权,ZL 2012 1 0406707.3

    19. 史进进,张红岭, 张振中,高君,叶凡,刘艳,余晓媛,张静,马柔柔,刘瑞瑗,王蕾,侯琳, 一种水溶性碳纳米管及其应用,授权, ZL 2012 1 0406733.6

    20. 史进进, 张振中,刘艳,张静,马柔柔,余晓媛,高君,刘瑞瑗, 以银/氧化石墨烯复合纳米粒为载体的近红外光药物控释系统的制备及其应用,授权, ZL 2013 1 0259899.4

    21. 史进进, 张振中,高君,余晓媛,刘艳,刘瑞瑗,马柔柔,张静, 银∕富勒烯纳米复合材料的制备及其作为抗菌剂的应用,授权, ZL 2013 1 0256770.8

    22. 祝侠丽, 张振中,谢莹霞,黄胜楠,侯琳,张慧娟,王蕾,史进进,张英杰,黄河清, 一种隐形热敏脂质体的制备及其药物转运系统在肿瘤治疗药物中的应用, 授权, ZL 2013 1 0494933.6

    23. 张振中,史进进,王蕾,王真真,张红岭,张超峰,陈成群, 一种水溶性富勒烯及其制备应用方法,授权, ZL 2012 1 0180631.7

    24. 张振中,张明月,赵永星,王蕾,史进进, 一种水分散性的碳纳米管冻干粉及其制备方法,授权, ZL 2011 1 0154812.8

    25. 史进进, 张振中,张静,余晓媛,高君,刘艳,马柔柔,刘瑞瑗,王蕾,王真真,李璐璐,王红红,张富丽, 多机制治疗肿瘤光热控释长循环药物转运系统的制备方法及其应用,授权, ZL 2012 1 0573805.6

    26. 侯琳, 张振中,胡志军,张红岭,冯倩华,王亚婷, 透明质酸修饰的氧化石墨烯及其药物组合物的制备方法与应用,授权, ZL 2012 1 0561306.5

    27. 张楠,王培, 张振中,徐霞,郭晓静,鲁春云,侯瑞瑞,李佳,张红岭,夏亚丹,王维嘉,陈燕,牛利锋,高书林, 一种2-甲氧基雌二醇白蛋白纳米冻干剂制备方法及其应用,授权, ZL 2014 1 0822045.7

    28. 侯琳, 张振中,石宇洋,蒋桂香,毛艳艳,杨晓敏,任俊晓,冯倩华,王亚婷, 一种基于碳材料的多糖类口服结肠靶向水凝胶的制备方法与应用,授权, ZL 2014 1 0621958.2

    29. 王蕾,史进进, 张振中,刘艳,马柔柔,张静,余晓媛,刘瑞瑗,高君, 镧系金属负载碳纳米材料水溶性衍生物的合成方法及其应用,授权, ZL 2013 1 0258048.8

    学术论文:

    1. Hou, L., X. Shan, L. Hao, Q. Feng and Z. Zhang (2017). "Copper sulfide nanoparticle-based localized drug delivery system as an effective cancer synergistic treatment and theranostic platform." Acta Biomater 54: 307-320.

    2. Guo, X., C. Chen, X. Liu, P. Hou, X. Guo, F. Ding, Z. Wang, Y. Hu, Z. Li and Z. Zhang (2017). "High oral bioavailability of 2-methoxyestradiol in PEG-PLGA micelles-microspheres for cancer therapy." Eur J Pharm Biopharm.

    3. Liu, Y., D. Li, X. Guo, H. Xu, Z. Li, Y. Zhang, C. Song, R. Fan, X. Tang and Z. Zhang (2017). "A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting." Int J Nanomedicine 12: 2227-2242

    4. Wang, L., D. Li, Y. Hao, M. Niu, Y. Hu, H. Zhao, J. Chang, Z. Zhang and Y. Zhang (2017). "Gold nanorod-based poly(lactic-co-glycolic acid) with manganese dioxide core-shell structured multifunctional nanoplatform for cancer theranostic applications." Int J Nanomedicine 12: 3059-3075.

    5. Yan, C., C. Chen, L. Hou, H. Zhang, Y. Che, Y. Qi, X. Zhang, J. Cheng and Z. Zhang (2017). "Single-walled carbon nanotube-loaded doxorubicin and Gd-DTPA for targeted drug delivery and magnetic resonance imaging." J Drug Target 25(2): 163-171.

    6. Zhang, H., H. Zhang, X. Zhu, X. Zhang, Q. Chen, J. Chen, L. Hou and Z. Zhang (2017). "Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery." Oncotarget.

    7. Zhu, X., H. Huang, Y. Zhang, H. Zhang, L. Hou and Z. Zhang (2017). "Cit/CuS@Fe3O4-based and enzyme-responsive magnetic nanoparticles for tumor chemotherapy, photothermal, and photodynamic therapy." J Biomater Appl 31(7): 1010-1025.

    8. Zhu, X., Y. Zhang, H. Huang, H. Zhang, L. Hou and Z. Zhang (2017). "Folic acid-modified and functionalized CuS nanocrystal-based nanoparticles for combined tumor chemo- and photothermal therapy." J Drug Target 25(5): 425-435

    9. Feng, Q., Y. Zhang, W. Zhang, Y. Hao, Y. Wang, H. Zhang, L. Hou and Z. Zhang (2017). "Programmed near-infrared light-responsive drug delivery system for combined magnetic tumor-targeting magnetic resonance imaging and chemo-phototherapy." Acta Biomater 49: 402-413.

    10. Feng, Q., Y. Zhang, W. Zhang, X. Shan, Y. Yuan, H. Zhang, L. Hou and Z. Zhang (2016). "Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography." Acta Biomater 38: 129-142

    11. Hao, Y., L. Wang, B. Zhang, D. Li, D. Meng, J. Shi, H. Zhang, Z. Zhang and Y. Zhang (2016). "Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application." Int J Nanomedicine 11: 1759-1778

    12. Hao, Y., L. Wang, B. Zhang, H. Zhao, M. Niu, Y. Hu, C. Zheng, H. Zhang, J. Chang, Z. Zhang and Y. Zhang (2016). "Multifunctional nanosheets based on folic acid modified manganese oxide for tumor-targeting theranostic application." Nanotechnology 27(2): 025101

    13. Hou, L., Q. Feng, Y. Wang, X. Yang, J. Ren, Y. Shi, X. Shan, Y. Yuan, Y. Wang and Z. Zhang (2016). "Multifunctional hyaluronic acid modified graphene oxide loaded with mitoxantrone for overcoming drug resistance in cancer." Nanotechnology 27(1): 015701

    14. Hou, L., Y. Shi, G. Jiang, W. Liu, H. Han, Q. Feng, J. Ren, Y. Yuan, Y. Wang, J. Shi and Z. Zhang (2016). "Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery." Nanotechnology 27(31): 315105

    15. Hou, L., X. Yang, J. Ren, Y. Wang, H. Zhang, Q. Feng, Y. Shi, X. Shan, Y. Yuan and Z. Zhang (2016). "A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging." Int J Nanomedicine 11: 607-624

    16. Li, H., Y. Hao, N. Wang, L. Wang, S. Jia, Y. Wang, L. Yang, Y. Zhang and Z. Zhang (2016). "DOTAP functionalizing single-walled carbon nanotubes as non-viral vectors for efficient intracellular siRNA delivery." Drug Deliv 23(3): 840-848

    17. Ren, X., L. Liu, Y. Zhou, Y. Zhu, H. Zhang, Z. Zhang and H. Li (2016). "Nanoparticle siRNA against BMI-1 with a Polyethylenimine-Laminarin Conjugate for Gene Therapy in Human Breast Cancer." Bioconjug Chem 27(1): 66-73

    18. Shi, J., Z. Chen, L. Wang, B. Wang, L. Xu, L. Hou and Z. Zhang (2016). "A tumor-specific cleavable nanosystem of PEG-modified C60@Au hybrid aggregates for radio frequency-controlled release, hyperthermia, photodynamic therapy and X-ray imaging." Acta Biomater 29: 282-297

    19. Shi, J., B. Wang, Z. Chen, W. Liu, J. Pan, L. Hou and Z. Zhang (2016). "A Multi-Functional Tumor Theranostic Nanoplatform for MRI Guided Photothermal-Chemotherapy." Pharm Res 33(6): 1472-1485

    20. Shi, J., B. Wang, L. Wang, T. Lu, Y. Fu, H. Zhang and Z. Zhang (2016). "Fullerene (C60)-based tumor-targeting nanoparticles with "off-on" state for enhanced treatment of cancer." J Control Release 235: 245-258

    21. Zhang, H., Q. Chen, X. Zhang, X. Zhu, J. Chen, H. Zhang, L. Hou and Z. Zhang (2016). "An Intelligent and Tumor-Responsive Fe2+ Donor and Fe2+-Dependent Drugs Cotransport System." ACS Appl Mater Interfaces 8(49): 33484-33498

    22. Zhang, H., Y. Ji, Q. Chen, X. Zhu, X. Zhang, Z. Tan, Q. Tian, X. Yang and Z. Zhang (2016). "In vitro and in vivo chemo-phototherapy of magnetic TiO2 drug delivery system formed by pH-sensitive coordination bond." J Biomater Appl 31(4): 568-581

    23. Zhu, X., H. Huang, Y. Zhang, H. Zhang, L. Hou and Z. Zhang (2017). "Cit/CuS@Fe3O4-based and enzyme-responsive magnetic nanoparticles for tumor chemotherapy, photothermal, and photodynamic therapy." J Biomater Appl 31(7): 1010-1025

    24. Du, B., S. Han, H. Li, F. Zhao, X. Su, X. Cao and Z. Zhang (2015). "Multi-functional liposomes showing radiofrequency-triggered release and magnetic resonance imaging for tumor multi-mechanism therapy." Nanoscale 7(12): 5411-5426.

    25. Hao, Y., B. Zhang, C. Zheng, R. Ji, X. Ren, F. Guo, S. Sun, J. Shi, H. Zhang, Z. Zhang, L. Wang and Y. Zhang (2015). "The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging." J Control Release 220(Pt A): 545-555

    26. Hou, L., H. Zhang, Y. Wang, L. Wang, X. Yang and Z. Zhang (2015). "Hyaluronic acid-functionalized single-walled carbon nanotubes as tumor-targeting MRI contrast agent." Int J Nanomedicine 10: 4507-4520.

    27. Li, Y., R. Liu, Y. Shi, Z. Zhang and X. Zhang (2015). "Zwitterionic poly(carboxybetaine)-based cationic liposomes for effective delivery of small interfering RNA therapeutics without accelerated blood clearance phenomenon." Theranostics 5(6): 583-596

    28. Li, Y., R. Liu, J. Yang, Y. Shi, G. Ma, Z. Zhang and X. Zhang (2015). "Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior." Biomaterials 41: 1-14.

    29. Li, Z., Y. Ou-Yang, Y. Liu, Y. Q. Wang, X. L. Zhu and Z. Z. Zhang (2015). "Folic acid-conjugated TiO2-doped mesoporous carbonaceous nanocomposites loaded with Mitoxantrone HCl for chemo-photodynamic therapy." Photochem Photobiol Sci 14(6): 1197-1206

    30. Li, Z., F. L. Zhang, L. L. Pan, X. L. Zhu and Z. Z. Zhang (2015). "Preparation and characterization of injectable Mitoxantrone poly (lactic acid)/fullerene implants for in vivo chemo-photodynamic therapy." J Photochem Photobiol B 149: 51-57

    31. Shi, J., Z. Chen, B. Wang, L. Wang, T. Lu and Z. Zhang (2015). "Reactive Oxygen Species-Manipulated Drug Release from a Smart Envelope-Type Mesoporous Titanium Nanovehicle for Tumor Sonodynamic-Chemotherapy." ACS Appl Mater Interfaces 7(51): 28554-28565

    32. Wang, L., Y. Hao, H. Li, Y. Zhao, D. Meng, D. Li, J. Shi, H. Zhang, Z. Zhang and Y. Zhang (2015). "Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles." J Drug Target 23(9): 832-846

    33. Wang, L., D. Meng, Y. Hao, Y. Zhao, D. Li, B. Zhang, Y. Zhang and Z. Zhang (2015). "Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications." J Biomater Appl 30(5): 547-557

    34. Wang, L., P. Zhang, J. Shi, Y. Hao, D. Meng, Y. Zhao, Y. Yanyan, D. Li, J. Chang and Z. Zhang (2015). "Radiofrequency-triggered tumor-targeting delivery system for theranostics application." ACS Appl Mater Interfaces 7(10): 5736-5747

    35. Zhang, H., L. Hou, X. Jiao, Y. Ji, X. Zhu and Z. Zhang (2015). "Transferrin-mediated fullerenes nanoparticles as Fe(2+)-dependent drug vehicles for synergistic anti-tumor efficacy." Biomaterials 37: 353-366

    36. Zhang, H., Y. Ji, Q. Chen, X. Jiao, L. Hou, X. Zhu and Z. Zhang (2015). "Enhancement of cytotoxicity of artemisinin toward cancer cells by transferrin-mediated carbon nanotubes nanoparticles." J Drug Target 23(6): 552-567

    37. Zhu, X., H. Huang, Y. Zhang, Y. Xie, L. Hou, H. Zhang and Z. Zhang (2015). "Investigation on Single-walled Carbon Nanotubes-Liposomes Conjugate to Treatment Tumor with Dual-mechanism." Curr Pharm Biotechnol 16(10): 927-936

    38. Zhu, X., H. Zhang, H. Huang, Y. Zhang, L. Hou and Z. Zhang (2015). "Functionalized graphene oxide-based thermosensitive hydrogel for magnetic hyperthermia therapy on tumors." Nanotechnology 26(36): 365103

    39. Guo, X., R. Ding, Y. Zhang, L. Ye, X. Liu, C. Chen, Z. Zhang and Y. Zhang (2014). "Dual role of photosensitizer and carrier material of fullerene in micelles for chemo-photodynamic therapy of cancer." J Pharm Sci 103(10): 3225-3234

    40. Guo, X., X. Zhang, L. Ye, Y. Zhang, R. Ding, Y. Hao, Y. Zhao, Z. Zhang and Y. Zhang (2014). "Inhalable microspheres embedding chitosan-coated PLGA nanoparticles for 2-methoxyestradiol." J Drug Target 22(5): 421-427

    41. Li, H., N. Zhang, Y. Hao, Y. Wang, S. Jia, H. Zhang, Y. Zhang and Z. Zhang (2014). "Formulation of curcumin delivery with functionalized single-walled carbon nanotubes: characteristics and anticancer effects in vitro." Drug Deliv 21(5): 379-387

    42. Li, Y., R. Liu, J. Yang, G. Ma, Z. Zhang and X. Zhang (2014). "Dual sensitive and temporally controlled camptothecin prodrug liposomes codelivery of siRNA for high efficiency tumor therapy." Biomaterials 35(36): 9731-9745

    43. Li, Y., R. Liu, J. Yang, Y. Shi, G. Ma, Z. Zhang and X. Zhang (2015). "Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior." Biomaterials 41: 1-14.

    44. Li, Z., L. L. Pan, F. L. Zhang, X. L. Zhu, Y. Liu and Z. Z. Zhang (2014). "5-Aminolevulinic acid-loaded fullerene nanoparticles for in vitro and in vivo photodynamic therapy." Photochem Photobiol 90(5): 1144-1149

    45. Shi, J., Y. Liu, L. Wang, J. Gao, J. Zhang, X. Yu, R. Ma, R. Liu and Z. Zhang (2014). "A tumoral acidic pH-responsive drug delivery system based on a novel photosensitizer (fullerene) for in vitro and in vivo chemo-photodynamic therapy." Acta Biomater 10(3): 1280-1291

    46. Shi, J., L. Wang, J. Gao, Y. Liu, J. Zhang, R. Ma, R. Liu and Z. Zhang (2014). "A fullerene-based multi-functional nanoplatform for cancer theranostic applications." Biomaterials 35(22): 5771-5784

    47. Shi, J., L. Wang, J. Zhang, R. Ma, J. Gao, Y. Liu, C. Zhang and Z. Zhang (2014). "A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@Ag nanoparticles for chemo-photothermal therapy and X-ray imaging." Biomaterials 35(22): 5847-5861

    48. Wang, L., J. Shi, R. Liu, Y. Liu, J. Zhang, X. Yu, J. Gao, C. Zhang and Z. Zhang (2014). "Photodynamic effect of functionalized single-walled carbon nanotubes: a potential sensitizer for photodynamic therapy." Nanoscale 6(9): 4642-4651

    49. Zhang, H., L. Hou, X. Jiao, J. Yandan, X. Zhu, L. Hongji, X. Chen, J. Ren, Y. Xia and Z. Zhang (2014). "In vitro and in vivo evaluation of antitumor drug-loaded aptamer targeted single-walled carbon nanotubes system." Curr Pharm Biotechnol 14(13): 1105-1117

    50. Zhao, B., L. Sun, W. Zhang, Y. Wang, J. Zhu, X. Zhu, L. Yang, C. Li, Z. Zhang and Y. Zhang (2014). "Secretion of intestinal goblet cells: a novel excretion pathway of nanoparticles." Nanomedicine 10(4): 839-849

    51. Zhu, X., S. Huang, H. Huang, Y. Zhang, Y. Xie, L. Hou, H. Zhang, J. Shi and Z. Zhang (2014). "In vitro and in vivo anti-cancer effects of targeting and photothermal sensitive solid lipid nanoparticles." J Drug Target 22(9): 822-828

    52. Zhu, X., Y. Xie, Y. Zhang, H. Huang, S. Huang, L. Hou, H. Zhang, Z. Li, J. Shi and Z. Zhang (2014). "Thermo-sensitive liposomes loaded with doxorubicin and lysine modified single-walled carbon nanotubes as tumor-targeting drug delivery system." J Biomater Appl 29(5): 769-779

    53. Chen, C., L. Hou, H. Zhang, L. Zhu, H. Zhang, C. Zhang, J. Shi, L. Wang, X. Jia and Z. Zhang (2013). "Single-walled carbon nanotubes mediated targeted tamoxifen delivery system using aspargine-glycine-arginine peptide." J Drug Target 21(9): 809-821

    54. Chen, C., H. Zhang, L. Hou, J. Shi, L. Wang, C. Zhang, M. Zhang, H. Zhang, X. Shi, H. Li and Z. Zhang (2013). "Single-walled carbon nanotubes mediated neovascularity targeted antitumor drug delivery system." J Pharm Pharm Sci 16(1): 40-51

    55. Du, B., L. Pang, H. Li, S. Ma, Y. Li, X. Jia and Z. Zhang (2013). "Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of indapamide enantiomers in rats." J Chromatogr B Analyt Technol Biomed Life Sci 932: 88-91

    56. Li, H., N. Zhang, Y. Hao, Y. Wang, S. Jia, H. Zhang, Y. Zhang and Z. Zhang (2014). "Formulation of curcumin delivery with functionalized single-walled carbon nanotubes: characteristics and anticancer effects in vitro." Drug Deliv 21(5): 379-387

    57. Shi, J., R. Ma, L. Wang, J. Zhang, R. Liu, L. Li, Y. Liu, L. Hou, X. Yu, J. Gao and Z. Zhang (2013). "The application of hyaluronic acid-derivatized carbon nanotubes in hematoporphyrin monomethyl ether-based photodynamic therapy for in vivo and in vitro cancer treatment." Int J Nanomedicine 8: 2361-2373

    58. Shi, J., Z. Wang, L. Wang, H. Wang, L. Li, X. Yu, J. Zhang, R. Ma and Z. Zhang (2013). "Photodynamic therapy of a 2-methoxyestradiol tumor-targeting drug delivery system mediated by Asn-Gly-Arg in breast cancer." Int J Nanomedicine 8: 1551-1562

    59. Shi, J., Z. Wang, L. Wang, H. Wang, L. Li, X. Yu, J. Zhang, R. Ma and Z. Zhang (2013). "Photodynamic therapy of a 2-methoxyestradiol tumor-targeting drug delivery system mediated by Asn-Gly-Arg in breast cancer." Int J Nanomedicine 8: 1551-1562

    60. Shi, J., X. Yu, L. Wang, Y. Liu, J. Gao, J. Zhang, R. Ma, R. Liu and Z. Zhang (2013). "PEGylated fullerene/iron oxide nanocomposites for photodynamic therapy, targeted drug delivery and MR imaging." Biomaterials 34(37): 9666-9677

    61. Shi, J., H. Zhang, L. Wang, L. Li, H. Wang, Z. Wang, Z. Li, C. Chen, L. Hou, C. Zhang and Z. Zhang (2013). "PEI-derivatized fullerene drug delivery using folate as a homing device targeting to tumor." Biomaterials 34(1): 251-261

    62. Wang, L., J. Shi, X. Jia, R. Liu, H. Wang, Z. Wang, L. Li, J. Zhang, C. Zhang and Z. Zhang (2013). "NIR-/pH-Responsive drug delivery of functionalized single-walled carbon nanotubes for potential application in cancer chemo-photothermal therapy." Pharm Res 30(11): 2757-2771

    63. Wang, L., J. Shi, H. Zhang, H. Li, Y. Gao, Z. Wang, H. Wang, L. Li, C. Zhang, C. Chen, Z. Zhang and Y. Zhang (2013). "Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes." Biomaterials 34(1): 262-274

    64. Zhou, J., Q. Liu, G. J. Fu and Z. Z. Zhang (2013). "Separation of mandelic acid and its derivatives with new immobilized cellulose chiral stationary phase." J Zhejiang Univ Sci B 14(7): 615-620

    65. Guo, X., Y. Xing, Q. Mei, H. Zhang, Z. Zhang and F. Cui (2012). "Preparation and cytotoxicity of 2-methoxyestradiol-loaded solid lipid nanoparticles." Anticancer Drugs 23(2): 185-190

    66. Guo, X., Y. Xing, X. Zhang, J. Li, Q. Mei, H. Zhang, C. Chen, Z. Zhang and F. Cui (2012). "In vivo controlled release and prolonged antitumor effects of 2-methoxyestradiol solid lipid nanoparticles incorporated into a thermosensitive hydrogel." Drug Deliv 19(4): 188-193

    67. Shen, G., Q. Wang, Q. Zhang, H. Sun, Y. Zhao, Z. Zhang and B. Du (2012). "Tissue distribution of 2-methoxyestradiol nanosuspension in rats and its antitumor activity in C57BL/6 mice bearing lewis lung carcinoma." Drug Deliv 19(7): 327-333

    68. Zhou, J., Y. Li, Q. Liu, G. Fu and Z. Zhang (2013). "Capillary electrophoresis of clenbuterol enantiomers and NMR investigation of the clenbuterol/carboxymethyl-beta-cyclodextrin complex." J Chromatogr Sci 51(3): 237-241

    69. Du, B., Z. Zhao, H. Sun, S. Ma, J. Jin and Z. Zhang (2012). "Effects of 2-methoxyestradiol on proliferation, apoptosis and gene expression of cyclin B1 and c-Myc in esophageal carcinoma EC9706 cells." Cell Biochem Funct 30(2): 158-165

    70. Du, S., L. Zhu, B. Du, X. Shi, Z. Zhang, S. Wang and C. Zhang (2012). "Pharmacokinetic evaluation and antitumor activity of 2-methoxyestradiol nanosuspension." Drug Dev Ind Pharm 38(4): 431-438

    71. Han, S., Y. Zhang, Q. Chen, Y. Duan, T. Zheng, X. Hu, Z. Zhang and L. Zhang (2011). "Fluconazole inhibits hERG K(+) channel by direct block and disruption of protein trafficking." Eur J Pharmacol 650(1): 138-144

    72. Hu, Y., Y. Shen, B. Ji, L. Wang, Z. Zhang and Y. Zhang (2011). "Combinational RNAi gene therapy of hepatocellular carcinoma by targeting human EGFR and TERT." Eur J Pharm Sci 42(4): 387-391

    73. Hu, Y., Y. Shen, B. Ji, S. Yin, X. Ren, T. Chen, Y. Ma, Z. Zhang and Y. Zhang (2011). "Liver-specific gene therapy of hepatocellular carcinoma by targeting human telomerase reverse transcriptase with pegylated immuno-lipopolyplexes." Eur J Pharm Biopharm 78(3): 320-325

    74. Ren, X., Y. Ma, M. Xu, T. Chen, Z. Zhang and Y. Zhang (2011). "Construction, modification and evaluation of apolipoprotein A-I promoter-driven shRNA expression vectors against hTERT." Plasmid 65(1): 42-50

    75. Wang, L., H. Y. Hua, W. J. Liu, Y. X. Zhao and Z. Z. Zhang (2011). "Pharmacokinetics of hydroxycamptothecin nanosuspensions in rats." Pharmazie 66(7): 547-548

    76. Wang, L., M. Zhang, N. Zhang, J. Shi, H. Zhang, M. Li, C. Lu and Z. Zhang (2011). "Synergistic enhancement of cancer therapy using a combination of docetaxel and photothermal ablation induced by single-walled carbon nanotubes." Int J Nanomedicine 6: 2641-2652

    77. Zhang, Q., Y. Ma, Y. F. Cheng, W. J. Li, Z. Zhang and S. Y. Chen (2011). "Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells." Cancer Lett 313(2): 201-210

    78. Zhou, T., X. Jia, H. Li, J. Wang, H. Zhang, Y. A and Z. Zhang (2011). "New tumor-targeted nanosized delivery carrier for oligonucleotides: characteristics in vitro and in vivo." Int J Nanomedicine 6: 1527-1534

    79. Du, B., X. T. Li, Y. Zhao, Y. M. A and Z. Z. Zhang (2010). "Preparation and characterization of freeze-dried 2-methoxyestradiol nanoparticle powders." Pharmazie 65(7): 471-476

    80. Du, B., Y. Li, X. Li, Y. A, C. Chen and Z. Zhang (2010). "Preparation, characterization and in vivo evaluation of 2-methoxyestradiol-loaded liposomes." Int J Pharm 384(1-2): 140-147

    81. Du, B., Y. Yan, Y. Li, S. Wang and Z. Zhang (2010). "Preparation and passive target of 5-fluorouracil solid lipid nanoparticles." Pharm Dev Technol 15(4): 346-353

    82. Hu, Y., K. Li, L. Wang, S. Yin, Z. Zhang and Y. Zhang (2010). "Pegylated immuno-lipopolyplexes: A novel non-viral gene delivery system for liver cancer therapy." J Control Release 144(1): 75-81

    83. Hu, Y., X. Ren, H. Wang, Y. Ma, L. Wang, Y. Shen, K. Oka, Z. Zhang and Y. Zhang (2010). "Liver-specific expression of an exogenous gene controlled by human apolipoprotein A-I promoter." Int J Pharm 398(1-2): 161-164


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