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    王蕾

    2017-10-16   点击:[]

     


    王蕾

    郑州大学直聘教授,博士(后),博士生导师,新加坡科技局细胞与分子生物学研究所(IMCB)访问学者、河南省教育厅科技创新人才、河南省教育厅学术技术带头人、郑州大学首批青年拔尖人才、河南省药学会药剂专委会委员、河南省药学会科普专委会委员、Chinese Chemical Letters青年编委及ACS NanoACS Applied Materials & Interfaces等多个国际知名SCI期刊审稿人。主要从事抗肿瘤纳米靶向给药系统的相关研究,涉及口服、静脉注射、皮下注射等多种制剂类型及化疗、放疗、免疫治疗等多种治疗方式。先后主持国家自然科学基金面上项目、国家自然科学基金地方联合项目、国家自然科学基金青年项目、中国博士后特别资助项目、中国博士后面上资助项目、河南省科技攻关项目等多个国际级及省部级科研项目。曾获河南省科学技术进步奖一等奖及二等奖、河南省医学科学技术进步奖、河南省优秀科技论文奖、河南省科学技术厅科学技术成果等。已在Advanced MaterialsIF25.803)、BiomaterialsIF10.273)、ACS Applied Materials & InterfacesIF8.456)、Journal of Controlled ReleaseIF7.901)等知名TOP期刊发表SCI论文近50篇。在Biomaterials上发表的题为Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes的论文入选美国《基本科学指标数据库》(ESI),成为进入世界前1%的高被引论文。申请专利20余项,授权19

    联系方式:邮箱:hahalei@139.com;电话:15136400500


    工作与教育经历:

     

    2017.01-至今,郑州大学,药学院药物分析系,直聘教授

    2016.09-2017.08.,新加坡新加坡科技局细胞与分子生物学研究所,访问学者

    2015.12-2016.12.,郑州大学,药学院药物分析系,副教授

    2014.03-2018.06.,郑州大学,化学与分子工程学院,博士后

    2012.10-2015.11,郑州大学,药学院药物分析系,讲师

    2007.09-2012.06,郑州大学,药物化学,博士

    2001.09-2006.06,新乡医学院,临床医学,学士

     

    社会兼职:

    • 河南省药学会药剂专委会委员

    • 河南省药学会科普专委会委员

    • Chinese Chemical Letters青年编委

    • ACS NanoACS Applied Materials & Interfaces等多个国际知名SCI期刊审稿人


    荣誉称号及奖励:


    • 2019年河南省教育厅科技创新人才

    • 2018年河南省科学技术进步奖一等奖

    • 2018年河南省教育厅学术技术带头人

    • 2018年河南省自然科学优秀学术论文一等奖

    • 2018年河南省优秀科技论文奖一等奖

    • 2017年河南省科学技术成果奖一等奖

    • 2016年河南省科学技术成果

    • 2014-2016年河南省优秀科技论文奖一等奖

    • 2014年河南省科学技术进步奖二等奖

    • 2013年河南省医学科学技术进步奖二等奖



    专著与教材:


    王蕾(参编),《实用现代色谱技术》,郑州大学出版社,2016年

    王蕾(参编),《分子生物药剂学》,郑州大学出版社,2016年



    主持或参加研究项目:


    1. 国家自然科学基金面上项目,81673021,一种智能型“自供氧”“可视化”肿瘤靶向治疗系统的研究,2017/01-2020/12,在研,主持。

    2. 国家自然科学基金地方联合项目,U1804183,肿瘤“主动招募”式仿生纳米“特工”对乳腺癌的治疗研究,2019/01-2021/12,在研,主持。

    3. 国家自然科学基金青年项目,81302717,多机制智能化控释磁性金纳米粒肿瘤靶向转运载体系统的研究,2014/01-2015/12,已结题,主持。

    4. 中国博士后特别资助项目,2015T80783,肿瘤逐级靶向多模式诊疗一体化给药系统的研究,2015/09-2018/03,已结题,主持。

    5. 中国博士后面上项目,2014M562002,射频远程控释肿瘤靶向诊断—治疗一体化给药系统的研究,2014/09-2018/03,已结题,主持。

    6. 河南省教育厅科技创新人才项目,20HASTIT049,基于纳米微囊泡的肿瘤免疫综合治疗研究,2020/01-2021/12,在研,主持。

    7. 河南省重点研发与推广专项科技攻关项目,182102310117,血卟啉单甲醚与丫啶黄联合增强肿瘤靶向声动力学治疗的研究,2018/01-2019/12,在研,主持。

    8. 河南省基础与前沿技术研究项目,182102310117,肿瘤逐层精准靶向诊疗控释给药系统的研究,2016/01-2017/12,已结题,主持。

    9. 郑州大学优秀青年教师发展基金,1421331073,射频远程控释肿瘤靶向诊断治疗多功能给药系统的研究,2014/09-2017/08,已结题,主持。

    10. 国家自然科学基金青年基金,81503038,H链铁蛋白介导的光磁双模式靶向探针的构建及肿瘤可视化成像研究,2016/01-2018/12,已结题,参与。

    11. 国家自然科学基金青年基金,81402893,核受体PPARγ组装DNA折纸色谱药物筛选新方法的研究,2015/01-2017/12,已结题,参与。


     

    国家发明专利:


    1. 王蕾,张振中,叶凡,史进进,高岩,李璐璐,张红岭,一种水溶性碳纳米管及其制备应用方法,授权,ZL 201210221300.3

    2. 王蕾,史进进,张振中,刘艳,马柔柔,张静,余晓媛,刘瑞瑗,高君,镧系金属负载碳纳米材料水溶性衍生物的合成方法及其应用,授权,ZL 201310258048.8

    3. 王蕾,刘瑞瑗,史进进,刘艳,张振中,马柔柔,高君,余晓媛,张静,一种阳离子化磁性碳纳米管的制备方法及应用,ZL 201310301753.1

    4. 王蕾,郝永伟,张云,赵亚林,孟德辉,李懂,史进进,张振中,一种基于聚乳酸-羟基乙酸共聚物的靶向共载药物传递系统纳米粒的制备方法及应用,授权,ZL 201310615647.0

    5. 王蕾,李爱荣,刘瑞瑗,史进进,张潘潘,郝永伟,张振中,一种磁性热敏脂质体纳米金复合物、制备方法及应用,授权,ZL 201410036393.1

    6. 王蕾,孟德辉,郝永伟,张潘潘,史进进,赵亚林,李懂,张兵详,张振中,张云,基于金纳米星的多功能抗肿瘤靶向诊断治疗药物的制备方法及应用,授权,ZL 201510199648.0

    7. 王蕾,孟德辉,郝永伟,张兵详,张潘潘,史进进,赵亚林,李懂,张振中,张云,光热和光动联合抗肿瘤的以叶酸介导的金纳米星为载体的药物传递系统的制备方法及应用,授权,ZL 201510204171.0

    8. 王蕾,张振中,张云,李懂,郝永伟,张冰祥,牛梦亚,孟德辉,郑翠霞,赵红娟,胡玉洁,张红岭,一种包覆二氧化锰片层的聚乳酸-羟基乙酸共聚物的制备方法及应用,授权,ZL 201610276557.7

    9. 王蕾,胡玉洁,郝永伟,郑翠霞,张红岭,张振中,张云,牛梦亚,赵洪娟,张兵祥,一种肿瘤靶向自组装核壳型载药纳米粒的制备方法及应用,公开,CN 106511296A

    10. 王蕾,赵洪娟,李丽,郝永伟,牛梦亚,郑翠霞,胡玉洁,宋庆龄,牛秀秀,张振中,一种基于介孔石墨相氮化碳的抗肿瘤药物载体的制备方法及应用,公开,CN 107496920 A


    学术论文: 


    1. Qingling Song,CuixiaZheng,JiajiaJia,Hongjuan Zhao,QianhuaFeng,Hongling Zhang, Lei Wang*,Zhenzhong Zhang*, Yun Zhang*, A Probiotic SporeBased Oral Autonomous Nanoparticles Generator for Cancer Therapy. Advanced Materials. 2019, 201903793. (影响因子: 25.803;一区)

    2. Lei Wang, Jinjin Shi, Hongling Zhang, Haixia Li, Yan Gao, Zhenzhen Wang, Honghong Wang, Lulu Li, Chaofeng Zhang, Chengqun Chen, Zhenzhong Zhang*, Yun Zhang*, Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes. Biomaterials. 2013, 34, 262-274.(影响因子: 10.273;一区)

    3. HongjuanZhao, Li Li, JunliZhang, CuixiaZheng, KailiDing, HuifangXiao, Lei Wang*, ZhenzhongZhang*. C-C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer. ACS Applied Materials &Interfaces. 2018;10(37):31124-35.(影响因子: 8.456;一区)

    4. Lei Wang, Panpan Zhang, Jinjin Shi, YongweiHao, DehuiMeng, Yalin Zhao, Yanyan Yin, Dong Li, Junbiao Chang*, Zhenzhong Zhang*, Radiofrequency-triggered tumor-targeting delivery system for theranostics application. ACS Appllied Materials & Interfaces. 2015, 7, 5736-5747. (影响因子: 8.456;一区)

    5. Lei Wang, YujieHu, YongweiHao, Li Li, CuixiaZheng, HongjuanZhao, MengyaNiu, YanyanYin, ZhenzhongZhang*, Yun Zhang*. Tumor-targeting core-shell structured nanoparticles for drug procedural controlled release and cancer sonodynamic combined therapy. Journal of Controlled Release. 2018;286:74-84.(影响因子: 7.901;一区)

    6. YongweiHao, Bingxiang Zhang, CuixiaZheng, RuiJi, XiangyiRen, FangfangGuo, Shili Sun, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Lei Wang*, Yun Zhang*, The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging. Journal of Controlled Release. 2015, 220, 545-555.(影响因子: 7.901;一区)

    7. Qingling Song, JiajiaJia, XiuxiuNiu, CuixiaZheng, Hongjuan Zhao, Lingling Sun, Hongling Zhang, Lei Wang*, Zhenzhong Zhang*, Yun Zhang*. An oral drug delivery system with programmed drug release and imaging properties for orthotopic colon cancer therapy. Nanoscale. 2019,11, 15958-15970.(影响因子:6.97;一区)

    8. Lei Wang, Jinjin Shi, Ruiyuan Liu, Yan Liu, Jing Zhang, Xiaoyuan Yu, Jun Gao, Chaofeng Zhang, Zhenzhong Zhang, Photodynamic effect of functionalized single-walled carbon nanotubes: a potential sensitizer for photodynamic therapy. Nanoscale. 2014, 6, 4642-4651.(影响因子:6.97;一区)

    9. YongweiHao, CuixiaZhen, Lei Wang*, JinjieZhang, XiuxiuNiu, QinglingSong, QianhuaFeng, HongjuanZhao, Li Li, HonglingZhang, ZhenzhongZhang*, Yun Zhang*. Tumor acidity-activatable manganese phosphate nanoplatform for amplification of photodynamic cancer therapy and magnetic resonance imaging. ActaBiomaterialia. 2017;62:293-305.(影响因子: 6.383;一区)

    10. Lei Wang, MengyaNiu, CuixiaZheng, HongjuanZhao, XiuxiuNiu, Li Li, YujieHu, YingjieZhang, Jinjin Shi*, ZhenzhongZhang*. A Core-Shell Nanoplatform for Synergistic Enhanced Sonodynamic Therapy of Hypoxic Tumor via Cascaded Strategy. Advanced Healthcare Materials. 2018:e1800819.(影响因子: 6.27;一区)

    11. Bin Du, Qinghui Wang, Ying Yang, Qian Du, Ying Liu, Wanying Zhu, TianguoXu, GuopengShen, Hanchun Yao*, Lei Wang*. Two-Way Cruise Nanosatellite Promotes Metastasis Inhibition by Immunochemotherapy. Biomacromolecules. 2019;20: 2873-2887.(影响因子: 5.667;一区)

    12. Yanyan Yin, Lingling Cui, Fulin Yan, Zhenzhong Zhang, Wenjie Li, Lei Wang*, Epigallocatechingallate based magnetic gold nanoshellsnanoplatform for cancer theranostic applications. Journal of Materials Chemistry B. 2017, 5, 454-463.(影响因子:5.047;一区)

    13. Lei Wang, Dong Li, YongweiHao, MengyaNiu, Yujie Hu, Hongling Zhang, Junbiao Chang, Zhenzhong Zhang, Yun Zhang, Gold nanorod-based poly(lactic-co-glycolic acid) with manganese dioxide core-shell structured multifunctional nanoplatform for cancer theranostic applications. International Journal of Nanomedicine. 2017, 12, 3059-3075.(一区)

    14. Lei Wang, Jinjin Shi, YongweiHao, Panpan Zhang, Yalin Zhao, DehuiMeng, Dong Li,; Junbiao Chang, Zhenzhong Zhang, Magnetic Multi-Walled Carbon Nanotubes for Tumor Theranostics. Journal of Biomedical Nanotechnology. 2015, 11, 1653-1661.(一区)

    15. Lei Wang, DehuiMeng, YongweiHao, Yujie Hu, MengyaNiu, CuixiaZheng, Yanyan Yin, Dong Li, Panpan Zhang, Junbiao Chang, A gold nanostar based multi-functional tumor-targeting nanoplatform for tumor theranostic applications. Journal of Materials Chemistry B. 2016, 4, 5895-5906.(影响因子:5.047;一区)

    16. YongweiHao#, Lei Wang#, Bingxiang Zhang, Dong Li, DehuiMeng, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Yun Zhang. Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application. International Journal of Nanomedicine. 2016, 11, 17591778. (一区)

    17. HongjuanZhao, Li Li, CuixiaZheng, YongweiHao, MengyaNiu, YujieHu, JunbiaoChang, ZhenzhongZhang*, Lei Wang*. An intelligent dual stimuli-responsive photosensitizer delivery system with O2-supplying for efficient photodynamic therapy. Colloids and Surfaces B-Biointerfaces. 2018;167:299-309.(二区)

    18. YongweiHao, Bingxiang Zhang, CuixiaZheng, MengyaNiu, HaochenGuo, Hongling Zhang, Junbiao Chang, Zhenzhong Zhang, Lei Wang*, Yun Zhang*, Multifunctional nanoplatform for enhanced photodynamic cancer therapy and magnetic resonance imaging. Colloids and Surfaces B-Biointerfaces. 2017, 151, 384-393.(二区)

    19. YongweiHao#, Lei Wang#, BingxiangZhang, HongjuanZhao, MengyaNiu, YujieHu, CuixiaZheng, HonglingZhang, JunbiaoChang, ZhenzhongZhang*, Yun Zhang*. Multifunctional nanosheets based on folic acid modified manganese oxide for tumor-targeting theranostic application. Nanotechnology. 2016;27(2):025101.(二区)

    20. Lei Wang, DehuiMeng, YongweiHao, Yalin Zhao, Dong Li, Bingxiang Zhang, Yun Zhang, Zhenzhong Zhang, Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications. Journal of Biomaterials Appllications. 2015, 30, 547-557.(二区)

    21. YongweiHao#, Lei Wang#, YalinZhao, DehuiMeng, Dong Li, HaixiaLi, BingxiangZhang, JinjinShi, HonglingZhang, ZhenzhongZhang*, Yun Zhang*. Targeted Imaging and Chemo-Phototherapy of Brain Cancer by a Multifunctional Drug Delivery System. Macromolecular Bioscience. 2015;15(11):1571-1585.(二区)

    22. Bin Du, TiantianQu, Zheng Chen, Xiaohui Cao, Shuping Han, GuopengShen, Lei Wang*, A novel restricted access material combined to molecularly imprinted polymers for selective solid-phase extraction and high performance liquid chromatography determination of 2-methoxyestradiol in plasma samples. Talanta. 2014, 129, 465-472.(二区)

    23. Lei Wang, Jinjin Shi, XinJia, Ruiyuan Liu, Honghong Wang, Zhenzhen Wang, Lulu Li, Jing Zhang, Chaofeng Zhang, Zhenzhong Zhang, NIR-/pH-Responsive drug delivery of functionalized single-walled carbon nanotubes for potential application in cancer chemo-photothermal therapy. Pharmaceutical Research. 2013, 30, 2757-2771.(二区)

    24. Lei Wang, Mingyue Zhang, Nan Zhang, Jinjin Shi, Hongling Zhang, Min Li, Chao Lu, Zhenzhong Zhang, Synergistic enhancement of cancer therapy using a combination of docetaxel and photothermal ablation induced by single-walled carbon nanotubes. International Journal of Nanomedicine. 2011, 6, 2641-2652.(二区)

     

     

     


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