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    王蕾

    2017-10-16   点击:[]


    王蕾

    郑州大学直聘教授,博士(后),硕士生导师。主要从事抗肿瘤纳米靶向给药系统的相关研究。曾获得河南省科学技术进步奖、河南省医学科学技术进步奖、河南省优秀科技论文奖、河南省科学技术厅科学技术成果等,博士毕业论文分别被评为当年河南省级优秀博士论文。先后主持国家自然科学基金青年基金1项、国家自然科学基金面上基金1项、中国博士后面上基金1项、中国博士后特别资助1项、郑州大学优秀青年教师发展基金1项。已发表30余篇SCI论文,在BiomaterialsNanoscaleACS Applied Materials & Interfaces等期刊发表多篇JCR一区论文。在Biomaterials上发表的题为Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes的论文于2014年入选美国《基本科学指标数据库》(ESI),成为进入世界前1%的高被引论文。申请专利20余项,授权16项。

    联系方式:邮箱:hahalei@139.com;电话:15136400500

    工作与教育经历:

    2017.1-至今,郑州大学,药学院药物分析系,直聘教授

    2015.12-至今,郑州大学,药学院药物分析系,副教授

    2014.3-至今,郑州大学,化学与分子工程学院,博士后

    2012.10-2015.11,郑州大学,药学院药物分析系,讲师

    2007.09-2012.06,郑州大学,药物化学,博士

    2001.09-2006.06,新乡医学院,临床医学,学士

    社会兼职:

    河南省药学研究会 理事

    中国药物制剂学会 会员

    河南省生物物理学会 会员

    荣誉称号及奖励:

    2016 河南省科技厅科学技术成果奖

    2014-2016 河南省优秀科技论文奖一等奖

    2014 河南省科学技术进步奖

    2013 河南省医学科学技术进步奖

    专著与教材:

    王蕾(参编),《实用现代色谱技术》,郑州大学出版社,2016

    王蕾(参编),《分子生物药剂学》,郑州大学出版社,2016

    主持或参加研究项目:

    1. 国家自然科学基金面上项目,81673021,一种智能型“自供氧”“可视化”肿瘤靶向治疗系统的研究,2017/01-2020/12,在研,主持

    2. 国家自然科学基金青年项目,81302717,多机制智能化控释磁性金纳米粒肿瘤靶向转运载体系统的研究,2014/01-2015/12,已结题,主持。

    3. 中国博士后特别资助项目,2015T80783,肿瘤逐级靶向多模式诊疗一体化给药系统的研究,2015/09-2018/03,在研,主持。

    4. 中国博士后面上项目,2014M562002,射频远程控释肿瘤靶向诊断—治疗一体化给药系统的研究,2014/09-2018/03,在研,主持。

    5. 郑州大学优秀青年教师发展基金,1421331073,射频远程控释肿瘤靶向诊断治疗多功能给药系统的研究,2014/09-2017/08,在研,主持。

    6. 国家自然科学基金青年基金,81503038,H链铁蛋白介导的光磁双模式靶向探针的构建及肿瘤可视化成像研究,2016/01-2018/12,在研,参与。

    7. 国家自然科学基金青年基金,81402893,核受体PPARγ组装DNA折纸色谱药物筛选新方法的研究,2015/01-2017/12,在研,参与。

    国家发明专利:

    1. 王蕾,张振中,叶凡,史进进,高岩,李璐璐,张红岭,一种水溶性碳纳米管及其制备应用方法,授权,ZL 201210221300.3

    2. 王蕾,史进进,张振中,刘艳,马柔柔,张静,余晓媛,刘瑞瑗,高君,镧系金属负载碳纳米材料水溶性衍生物的合成方法及其应用,授权,ZL 201310258048.8

    3. 王蕾,刘瑞瑗,史进进,刘艳,张振中,马柔柔,高君,余晓媛,张静,一种阳离子化磁性碳纳米管的制备方法及应用,ZL 201310301753.1

    4. 王蕾,郝永伟,张云,赵亚林,孟德辉,李懂,史进进,张振中,一种基于聚乳酸-羟基乙酸共聚物的靶向共载药物传递系统纳米粒的制备方法及应用,授权,ZL 201310615647.0

    5. 王蕾,李爱荣,刘瑞瑗,史进进,张潘潘,郝永伟,张振中,一种磁性热敏脂质体纳米金复合物、制备方法及应用,授权,ZL 201410036393.1

    6. 王蕾,孟德辉,郝永伟,张潘潘,史进进,赵亚林,李懂,张兵详,张振中,张云,基于金纳米星的多功能抗肿瘤靶向诊断治疗药物的制备方法及应用,公开,CN 104758948A

    7. 王蕾,孟德辉,郝永伟,张兵详,张潘潘,史进进,赵亚林,李懂,张振中,张云,光热和光动联合抗肿瘤的以叶酸介导的金纳米星为载体的药物传递系统的制备方法及应用,公开,CN 104826127A

    8. 王蕾,张振中,张云,李懂,郝永伟,张冰祥,牛梦亚,孟德辉,郑翠霞,赵红娟,胡玉洁,张红岭,一种包覆二氧化锰片层的聚乳酸-羟基乙酸共聚物的制备方法及应用,公开,CN 105906822A

    学术论文:

    1. Lei Wang, Jinjin Shi, Hongling Zhang, Haixia Li, Yan Gao, Zhenzhen Wang, Honghong Wang, Lulu Li, Chaofeng Zhang, Chengqun Chen, Zhenzhong Zhang, Yun Zhang, Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes. Biomaterials. 2013, 34, 262-274.(一区)

    2. Lei Wang, Jinjin Shi, Ruiyuan Liu, Yan Liu, Jing Zhang, Xiaoyuan Yu, Jun Gao, Chaofeng Zhang, Zhenzhong Zhang, Photodynamic effect of functionalized single-walled carbon nanotubes: a potential sensitizer for photodynamic therapy. Nanoscale. 2014, 6, 4642-4651.(一区)

    3. Lei Wang, Panpan Zhang, Jinjin Shi, Yongwei Hao, Dehui Meng, Yalin Zhao, Yanyan Yin, Dong Li, Junbiao Chang, Zhenzhong Zhang, Radiofrequency-triggered tumor-targeting delivery system for theranostics application. ACS Appllied Materials & Interfaces. 2015, 7, 5736-5747.(一区)

    4. Lei Wang, Dehui Meng, Yongwei Hao, Yujie Hu, Mengya Niu, Cuixia Zheng, Yanyan Yin, Dong Li, Panpan Zhang, Junbiao Chang, A gold nanostar based multi-functional tumor-targeting nanoplatform for tumor theranostic applications. Journal of Materials Chemistry B. 2016, 4, 5895-5906.(一区)

    5. Lei Wang, Jinjin Shi, Xin Jia, Ruiyuan Liu, Honghong Wang, Zhenzhen Wang, Lulu Li, Jing Zhang, Chaofeng Zhang, Zhenzhong Zhang, NIR-/pH-Responsive drug delivery of functionalized single-walled carbon nanotubes for potential application in cancer chemo-photothermal therapy. Pharmaceutical Research. 2013, 30, 2757-2771.(一区)

    6. Lei Wang, Mingyue Zhang, Nan Zhang, Jinjin Shi, Hongling Zhang, Min Li, Chao Lu, Zhenzhong Zhang, Synergistic enhancement of cancer therapy using a combination of docetaxel and photothermal ablation induced by single-walled carbon nanotubes. International Journal of Nanomedicine. 2011, 6, 2641-2652.(一区)

    7. Lei Wang, Dong Li, Yongwei Hao, Mengya Niu, Yujie Hu, Hongling Zhang, Junbiao Chang, Zhenzhong Zhang, Yun Zhang, Gold nanorod-based poly(lactic-co-glycolic acid) with manganese dioxide core-shell structured multifunctional nanoplatform for cancer theranostic applications. International Journal of Nanomedicine. 2017, 12, 3059-3075.(一区)

    8. Yongwei Hao, Bingxiang Zhang, Cuixia Zheng, Rui Ji, Xiangyi Ren, Fangfang Guo, Shili Sun, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Lei Wang*, Yun Zhang, The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging. J Control Release. 2015, 220, 545-555.(一区)

    9. Yanyan Yin, Lingling Cui, Fulin Yan, Zhenzhong Zhang, Wenjie Li, Lei Wang*, Epigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications. Journal of Materials Chemistry B. 2017, 5, 454-463.(一区)

    10. Lei Wang, Jinjin Shi, Yongwei Hao, Panpan Zhang, Yalin Zhao, Dehui Meng, Dong Li,; Junbiao Chang, Zhenzhong Zhang, Magnetic Multi-Walled Carbon Nanotubes for Tumor Theranostics. Journal of Biomedical Nanotechnology. 2015, 11, 1653-1661.(二区)

    11. Lei Wang, Dehui Meng, Yongwei Hao, Yalin Zhao, Dong Li, Bingxiang Zhang, Yun Zhang, Zhenzhong Zhang, Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications. Journal of Biomaterials Appllications. 2015, 30, 547-557.(二区)

    12. Bin Du, Tiantian Qu, Zheng Chen, Xiaohui Cao, Shuping Han, Guopeng Shen, Lei Wang*, A novel restricted access material combined to molecularly imprinted polymers for selective solid-phase extraction and high performance liquid chromatography determination of 2-methoxyestradiol in plasma samples. Talanta. 2014, 129, 465-472.(二区)

    13. Yongwei Hao, Bingxiang Zhang, Cuixia Zheng, Mengya Niu, Haochen Guo, Hongling Zhang, Junbiao Chang, Zhenzhong Zhang, Lei Wang*, Yun Zhang, Multifunctional nanoplatform for enhanced photodynamic cancer therapy and magnetic resonance imaging. Colloids Surf B Biointerfaces. 2017, 151, 384-393.(二区)

    14. Lei Wang, Yongwei Hao, Haixia Li, Yalin Zhao, Dehui Meng, Dong Li, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Yun Zhang, Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system: angiopep-2-modified poly(lactic-co-glycolic acid) nanoparticles. Journal of Drug Targeting. 2015, 23, 832-846.(三区)

    15. Lei Wang, Haiying Hua, Weijing Liu, Yongxing Zhao, Zhenzhong Zhang, Pharmacokinetics of hydroxycamptothecin nanosuspensions in rats. Pharmazie. 2011, 66, 547-548. (四区)

    16. Lei Wang, Ling Fu, Linlin Jing, Lu Jia, Studies of Chemical Constituents from Rosa chinensis Jacq. Chemical Journal of Chinese Universities-Chinese. 2012, 33, 2457-2461.(四区)

    17. 王蕾; 朱玲; 杜斌, 基于复合型药学人才培养的药物分析实验教学改革. 药学教育. 2014, 30, 54-56.(教学论文)

    18. 陈华艳; 尹延彦; 叶凡; 常俊标; 王蕾*, 微波热疗增强视网膜母细胞瘤化学治疗效应的体外研究. 眼科新进展. 2014, 34, 620-623.(中文核心期刊)



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