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    张金洁

    2017-10-17   点击:[]


    张金洁

    郑州大学药学院药剂系,郑州大学特聘副教授。近年来主要从事两方面研究,一是胰腺炎靶向给药系统的构建及其相关抗炎机理的研究,另一方面是高效克服粘液和上皮细胞屏障的口服递药系统的研究。发表SCI论文10余篇,分别发表于Journal of controlled release (IF: 7.7)Molecular pharmaceutics (IF: 4.3)International journal of nanomedicine (IF: 4.3) 等药剂学知名杂志;先后参与完成多项国家自然科学基金项目;获得授权发明专利1项。


    联系方式:

    邮箱 liger1029@126.com 电话 15638452902

    工作与教育经历:

    2016.6-至今,郑州大学,药学院药剂系,特聘副教授

    2010.09-2015.06,四川大学华西药学院,药剂学,博士

    2005.09-2009.06,郑州大学,药剂学,学士

    社会兼职:

    荣誉称号及奖励:

    专著与教材:

    主持或参加研究项目:

    1. 项目名称:基于乙肝病毒的嗜肝性原理构建的肝实质细胞主动靶向给药系统的研究,编号81273443,

    2. 基于近红外荧光成像技术的脑内Aβ斑块分析方法的基础研究,编号81402891,


    国家发明专利:

    1. 一种提高桑色素口服生物利用度的药物组合物,申请号:ZL201110275082.7,发明人:张志荣、龚涛、张金洁、孙逊。

    学术论文:

    1. Jianbo Li, Jinjie Zhang#Yao Fu, Tao Gong, Zhirong Zhang*. Dual pancreas- and lung- specific targeting therapy for local and systemic complications of acute pancreatitis. Journal of controlled release, 2015, 212,19-29.

    2. Jinjie Zhang, Jianbo Li, Yuan Ju, Yao Fu, Tao Gong, Zhirong Zhang*. Mechanism of enhanced oral absorption of morin by phospholipid complex based self-nanoemulsifying drug delivery system. Molecular Pharmaceutics. 2015,12(2),504513.

    3. Jinjie Zhang, Qiang Peng, Sanjun Shi, Qiang Zhang, Xun Sun, Tao Gong, Zhirong Zhang*. Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system loaded with morin–phospholipid complex. International journal of nanomedicine, 2010, 6(1),3405-3414.

    4. Jinjie Zhang, Jianbo Li, Nanxi Xiang, Yao Fu, Tao Gong, Zhirong Zhang*. Biodistribution, hypouricemic efficacy and therapeutic mechanism of morin phospholipid complex loaded self-nanoemulsifying drug delivery systems in an experimental hyperuricemic model in rats. Journal of Pharmacy and Pharmacology. 2016, 68(1):14–25.

    5. Xianghong Lian, Jianxia Dong, Jinjie Zhang, Yanwei Teng, Qing Lin, Yao Fu, Tao Gong*. Soluplus® based 9-nitrocamptothecin solid dispersion for peroral administration: Preparation, characterization, in vitro and in vivo evaluation. International Journal of Pharmaceutics. 2014,477 (1-2), 399-407.

    6. Xinyi He, Nanxi Xiang, Jinjie Zhang, Jing Zhou, Yao Fu, Tao Gong*, Zhirong Zhang. Encapsulation of teniposide into albumin nanoparticles with greatly lowered toxicity and enhanced antitumor activity. International Journal of pharmaceutics. 2015, 487(1–2), 250-259.

    7. Nanxi Xiang, Xu Zhou, Xinyi He, Yu Zhang, Jinjie Zhang, Yao Fu*. An injectable gel platform for the prolonged therapeutic effect of pitavastatin in the management of hyperlipidemia. Journal of Pharmaceutical Sciences. 2016,105 (3),1148-1155.

    8. Mei Hu, Jinjie Zhang, Rui Ding, Yao Fu, Tao Gong*, Zhirong Zhang. Improved oral bioavailability and therapeutic efficacy of dabigatran etexilate via Soluplus-TPGS binary mixed micelles system. Drug development and Industrial Pharmacy.2016,43(4).(IF=2.4)


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版权所有:河南省肿瘤重大疾病靶向治疗与诊断重点实验室

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