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    张慧娟

    2017-10-17   点击:[]


    张慧娟

    郑州大学药学院,讲师。研究方向为抗肿瘤药物纳米制剂。已发表SCI论文17篇,其中以第一作者及共同一作身份共发表12篇,5篇为一区文章,分别发表在Biomaterials, Journal of Material Chemistry B, ACS Applied Materials & Interfaces, Oncotarget, International journal of nanomedicine期刊上。申请国家发明专利8项,其中已授权3项。

    联系方式:邮箱zhanghuijuan4@163.com

    工作与教育经历:

    2017.9-至今,郑州大学,药学院药物分析系,讲师

    2013.09-2017.06,郑州大学,药物化学,博士

    2010.09-2013.06,郑州大学,药物分析,硕士

    2006.09-2010.06,中国药科大学,药学,学士

    主持或参加研究项目:

    1. 国家自然科学基金面上项目,81573364,远程调控介孔门控型磁性载体多机制治疗肿瘤研究,2016/01-2019/12,在研,参加

    2. 国家自然科学基金青年科学基金项目,81402893,核受体PPARγ组装DNA折纸色谱药物筛选新方法的研究,2015/01-2017/12,在研,参加。

    国家发明专利:

    1. 张振中,张慧娟,陈倩倩,冀嫣丹,焦晓静,侯琳,张红岭,一种透明质酸修饰的Au掺杂二氧化钛纳米管的制备方法及其应用,授权,ZL 2014 1 0652133.7  

    2. 张振中,张慧娟,冀嫣丹,侯琳,焦晓静,陈倩倩,张红岭,一种水溶性磁性二氧化钛及其制备方法与应用,授权,ZL 2014 1 0625576.7

    3. 张振中,张慧娟,焦晓静,陈倩倩,冀嫣丹,张红岭,侯琳,一种能提供一氧化氮的透明质酸硝酸酯去氧胆酸聚合物胶束的制备方法及其应用,授权,ZL 2014 1 0647093.7

    4. 张振中张慧娟张晓戈祝杏陈倩倩侯琳张红岭,一种Mn2+供体与氯喹类药物共转运体系的制备及应用,公开,CN106344925A

    5. 张振中,张慧娟,张晓戈,祝杏,张红岭,侯琳,一种超声调控型抗肿瘤药物递送系统的制备方法及应用,公开,CN106267199A

    6. 张红岭,张慧娟,张振中,陈倩倩,张晓戈,有抗肿瘤药物纳米层的透明质酸修饰的二氧化钛一氧化石墨烯复合材料制备方法及应用,公开,    CN105194679A

    7. 张振中,张慧娟,侯琳,张红岭,陈倩倩,焦晓静,一种介孔门控型的Fe2+供体与Fe2+依赖性抗肿瘤药物共转运体系及其制备方法与应用,公开,    CN105056244A

    8. 张振中,张慧娟,焦晓静,冀嫣丹,陈倩倩,祝侠丽,张红岭,一种二氧化钛碳纳米复合材料一聚合物复合水凝胶的制备方法与应用,公开,CN104306973A

    学术论文:

    1. Huijuan Zhang, Lin Hou, Xiaojing Jiao, Yandan Ji, Xiali Zhu, Zhenzhong Zhang*. Transferrin-mediated fullerenes nanoparticles as Fe2+-dependent drug vehicles for synergistic anti-tumor efficacy. Biomaterials, 2015, 37: 353-366(一区)

    2. Huijuan Zhang, Xiali Zhu, Yandan Ji, Xiaojing Jiao, Qianqian Chen, Lin Hou, Hongling Zhang, Zhenzhong Zhang*. Near-infrared-triggered in situ hybrid hydrogel system for synergistic cancer therapy. J Mater Chem B, 2015, 3: 6310-6326 (一区)

    3. Huijuan Zhang, Qianqian Chen, Xiaoge Zhang, Xing Zhu, Jianjiao Chen, Hongling Zhang, Lin Hou, Zhenzhong Zhang*. An Intelligent and Tumor-Responsive Fe2+ Donor and Fe2+-Dependent Drugs Cotransport System. ACS Appl. Mater. Interfaces, 2016, 8: 33484−33498(一区)

    4. Huijuan Zhang, Hongling Zhang, Xing Zhu, Xiaoge Zhang, Qianqian Chen, Jianjiao Chen, Lin Hou, Zhenzhong Zhang*. Visible-light-sensitive Titanium Dioxide Nanoplatform for Tumor-responsive Fe2+ Liberating and Artemisinin Delivery. Oncotarget, 2017, Published on line(一区)

    5. Huijuan Zhang, Xiaojing Jiao, Qianqian Chen, Yandan Ji, Xiaoge Zhang, Xing Zhu, Zhenzhong Zhang*. A multi-functional nanoplatform for tumor synergistic phototherapy. Nanotechnology, 2016, 27: 085104(二区)

    6. Huijuan Zhang, Yandan Ji, Qianqian Chen, Xing Zhu, Xiaoge Zhang, Zhiyuan Tan, Qianqian Tian, Xiangbo Yang, Zhenzhong Zhang*. In vitro and in vivo chemo- phototherapy of magnetic TiO2 drug delivery system formed by pH-sensitive coordination bond. Journal of biomaterials applications, 2016, 31(4): 568-581(二区)

    7. Huijuan Zhang, Yandan Ji, Qianqian Chen, Xiaojing Jiao, Lin Hou, Xiali Zhu, Zhenzhong Zhang*. Enhancement of cytotoxicity of artemisinin toward cancer cells by transferrin-mediated carbon nanotubes nanoparticles. Journal of drug targeting, 2015, 23: 552-567. (三区)

    8. Huijuan Zhang, Chengqun Chen, Lin Hou, Nan Jin, Jinjin Shi, Zhuo Wang, Yu Liu, Qianhua Feng, Zhenzhong Zhang*. Targeting and hyperthermia of doxorubicin by the delivery of single-walled carbon nanotubes to EC-109 cells. Journal of drug targeting, 2013, 21: 312-319(三区)

    9. Huijuan Zhang, Lin Hou, Xiaojing Jiao, Yandan Ji, Xiali Zhu, Hongji Li, Xiaozhe Chen, Junxiao Ren, Yadan Xia, Zhenzhong Zhang*. In vitro and in vivo Evaluation of Antitumor Drug-Loaded Aptamer Targeted Single-Walled Carbon Nanotubes System. Curr Pharm Biotechno., 2013, 14: 1105-1117(三区)

    10. Lin Hou#, Huijuan Zhang#, Yating Wang, Lili Wang, Xiaomin Yang, Zhenzhong Zhang*. Hyaluronic acid-functionalized single-walled carbon nanotubes as tumor- targeting MRI contrast agent. International journal of nanomedicine, 2015, 10: 4507-4520 (一区)

    11. Xiali Zhu#, Huijuan Zhang#, Heqing Huang, Yingjie Zhang, Lin Hou, Zhenzhong Zhang*. Functionalized graphene oxide-based thermosensitive hydrogel for magnetic hyperthermia therapy on tumors. Nanotechnology, 2015, 26: 365103(二区)

    12. Chengqun Chen#, Huijuan Zhang#, Lin Hou, Jinjin Shi, Lei Wang, Chaofeng Zhang, Mingyue Zhang, Hongling Zhang, Xiufang Shi, Huixiang Li, Zhenzhong Zhang*. Single-Walled Carbon Nanotubes Mediated Neovascularity Targeted Antitumor Drug Delivery System. J Pharm Pharm Sci., 2013, 16: 40-51(三区)

    13. Chengqun Chen, Lin Hou, Huijuan Zhang, Ling Zhu, Hongling Zhang, Chaofeng Zhang, Jinjin Shi, Lei Wang, Xin Jia, Zhenzhong Zhang*. Single-walled carbon nanotubes mediated targeted tamoxifen delivery system using aspargine-glycine-arginine peptide. Journal of drug targeting, 2013, 21: 809-821(三区)

    14. Lin Hou, Xiaomin Yang, Junxiao Ren, Yongchao Wang, Huijuan Zhang, Qianhua Feng, Yuyang Shi, Xiaoning Shan, Yujie Yuan, Zhenzhong Zhang*. A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging. International journal of nanomedicine, 2016, 11: 607-624. (一区)

    15. Lin Hou, Qianhua Feng, Yating Wang, Huijuan Zhang, Guixiang Jiang, Xiaomin Yang, Junxiao Ren, Xiali Zhu, Yuyang Shi, Zhenzhong Zhang*. Multifunctional nanosheets based on hyaluronic acid modified graphene oxide for tumor-targeting chemophotothermal therapy. J Nanopart Res., 2015, 17: 162(二区)

    16. Xiali Zhu, Shengnan Huang, Heqing Huang, Yingjie Zhang, Yingxia Xie, Lin Hou, Huijuan Zhang, Jinjin Shi, Zhenzhong Zhang*. In vitro and in vivo anti-cancer effects of targeting and photothermal sensitive solid lipid nanoparticles. Journal of drug targeting, 2014, 22: 822-828(三区)

    17. Xiali Zhu, Yingxia Xie, Yingjie Zhang, Heqing Huang, Shengnan Huang, Lin Hou, Huijuan Zhang, Zhi Li, Jinjin Shi, Zhenzhong Zhang*. Thermo-sensitive liposomes loaded with doxorubicin and lysine modified single-walled carbon nanotubes as tumor-targeting drug delivery system. Journal of biomaterials applications, 2014, 29: 769-779(二区)



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