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    张开翔

    2017-10-24   点击:[]

    郑州大学药学院,直聘副教授,九三学社社员。先后毕业于同济大学材料科学与工程学院和清华大学化学系,获得学士学位和博士学位,20122014年间于美国加州大学尓湾分校从事科学研究。累计发表SCI收录论文20篇,以第一作者在JACS, Angew, Chemical Science, Lab on Chip等期刊上发表论文5篇。研究方向为血液疾病标志物超灵敏分析,单细胞分析及基于CRISPR的基因分析。

    联系方式:zhangkx@zzu.edu.cn


    工作与教育经历:

    2017.7 至今       郑州大学          药学院     直聘副教授

    2012.8 2014.8     美国加州大学尓湾分校  药学院      访问学者

    2011.9 2017.7     清华大学         化学系       博士

    2007.9 2011.7     同济大学       材料科学与工程系   学士


    发明专利:

    US PATENT (WO2015048173) 第三发明人 Encapsulated Sensors And Sensing Systems For Bioassays And Diagnostics And Methods For Making And Using Them


    学术论文:

    2018

    1. K. Zhang, R. Deng, X. Teng, Y. Li, Y. Sun, X. Ren, J. Li. Direct Visualization of Single-Nucleotide Variation in mtDNA Using a CRISPR/Cas9-Mediated Proximity Ligation Assay. J. Am. Chem. Soc. 2018, 140, 11293-11301. (一区, 影响因子:14.357)

    2. K. Zhang, H. Gao, R. Deng, J. Li. Emerging Application of Nanotechnology for Controlling Cell Surface Receptors Clustering. Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201809006. (一区,影响因子:12.102)

    3. R. Deng, K. Zhang, L. Wang, X. Ren, Y. Sun, J. Li. DNA-Sequence-Encoded Rolling Circle Amplicon for Single-Cell RNA Imaging. Chem 2018, 4, 1373.(影响因子:14.104

    4. X. Ren, R. Deng, K. Zhang, Y. Sun, X. Teng, J. Li. SpliceRCA: in Situ Single-Cell Analysis of mRNA Splicing Variants. ACS Cent. Sci. 2018, 4, 680. (影响因子:11.228)

    5. Y. Sun, K. Zhang, R. Deng, X. Ren, C. Wu, J. Li. Tunable stiffness of graphene oxide/polyacrylamide composite scaffolds regulates cytoskeleton assembly. Chemical Science, 2018, 9, 6516. (一区,影响因子:9.063)

    6. J. Zhang, J. Shi, W. Liu, K. Zhang, H. Zhao, H. Zhang, Z. Zhang. A simple, specific and on-off type MUC1 fluorescence aptasensor based on exosomes for detection of breast cancer. Sensors Actuators B: Chem. 2018, 276, 552. (一区,影响因子:5.667)

    2012-2017

    7. K. Zhang, R. Deng, Y. Sun, L. Zhang, J. Li. Reversible control of cell membrane receptor function using DNA nano-spring multivalent ligands. Chemical Science, 2017, DOI: 10.1039/c7sc02489d. (一区,影响因子:9.063)

    8. K. Zhang, R. Deng, Y. Li, L. Zhang, J. Li. Cas9 cleavage assay for pre-screening of sgRNAs using nicking triggered isothermal amplification. Chemical Science, 2016, 7, 4951-4957. (一区,影响因子:9.063)

    9. K. Zhang, D. K. Kang, M. M. Ali, L. Liu, L. Labanieh, M. Lu, H. Riazifar, T. N. Nguyen, J. A. Zell, M. A. Digman, E. Gratton, J. Li, W. Zhao. Digital quantification of miRNA directly in plasma using integrated comprehensive droplet digital detection. Lab on a Chip, 2015, 15, 4217-4226. (一区,影响因子:6.045)

    10. M. M. Ali, F. Li, Z. Zhang, K. Zhang, D. K. Kang, J. A. Ankrum, X. C. Le, W. Zhao. Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine. Chemical Society Reviews, 2014, 43, 3324-3341. (一区,影响因子:38.618)

    11. R. Deng, K. Zhang, J. Li. Isothermal Amplification for MicroRNA Detection: From the Test Tube to the Cell. Accounts of Chemical Research, 2017, 50, 1059-1069. (一区,影响因子:20.268)

    12. D. K. Kang, M. M. Ali, K. Zhang, S. S. Huang, E. Peterson, M. A. Digman, E. Gratton, W. Zhao. Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nature Communications, 2014, 5, 5427. (一区,影响因子:12. 124)

    13. R. Deng, K. Zhang, Y. Sun, X. Ren, J. Li. Highly specific imaging of mRNA in single cells by target RNA-initiated rolling circle amplification. Chemical Science, 2017, 8, 3668-3675. (一区,影响因子:9.063)

    14. Y. Sun, R. Deng, K. Zhang, X. Ren, L. Zhang, J. Li. Single-cell study of the extracellular matrix effect on cell growth by in situ imaging of gene expression. Chemical Science. 2017, 8, 8019. (一区,影响因子:9.063)

    15. L. Zhang, K. Zhang, S. Rauf, D. Dong, Y. Liu, J. Li. Single-Molecule Analysis of Human Telomere Sequence Interactions with G-quadruplex Ligand. Analytical Chemistry, 2016, 88, 4533-4540. (一区,影响因子:6.320)

    16. L. Zhang, K. Zhang, G. Liu, M. Liu, Y. Liu, J. Li. Label-Free Nanopore Proximity Bioassay for Platelet-Derived Growth Factor Detection. Analytical Chemistry, 2015, 87, 5677-5682. (一区,影响因子:6.320)

    17. X. Ren, R. Deng, L. Wang, K. Zhang, J. Li. RNA splicing process analysis for identifying antisense oligonucleotide inhibitors with padlock probe-based isothermal amplification. Chemical Science, 2017, 8, 5692-5698. (一区,影响因子:8.668)

    18. L. Wu, H. Feng, M. Liu, K. Zhang, J. Li. Graphene-based hollow spheres as efficient electrocatalysts for oxygen reduction. Nanoscale,2013, 5, 10839-10843. (一区,影响因子:7.367)

    19. M. A. Eckert, R. Q. Vu, K. Zhang, D. K. Kang, M. M. Ali, C. Xu, W. Zhao. Novel Molecular and Nanosensors for In Vivo Sensing. Theranostics, 2013, 3 (8), 583-594. (一区,影响因子:8.766)

    20. D. K. Kang, M. M. Ali, K. Zhang, E. J. Pone, W. Zhao. Droplet microfluidics for single-molecule and single-cell analysis in cancer research, diagnosis and therapy. Trac-Trend Analytical Chemistry, 2014, 58, 145-153. (二区,影响因子:8.442)



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