2023年1月，本课题组在国际Top级学术期刊《Biotechnology Advances》上发表题为“Collagen Processing with Mesoscale Aggregates as Templates and Building Blocks”的研究综述，全面介绍了天然胶原聚集体的拆分方法、结构特点及其在生物医用、环境处理、食品包装和柔性电子器件方面的前沿应用。《Biotechnology Advances》为工程技术类一区Top期刊，最新影响因子为17.681。裴莹老师为文章第一作者，汤克勇老师为通讯作者，郑州大学为第一通讯单位，美国Tufts大学为合作单位。
Abstract
Collagen presents a well-organized hierarchical multilevel structure. Microfibers, fibers, and fiber bundles are the aggregates of natural collagen; which achieve an ideal balance of mechanical strength and toughness at the mesoscopic scale for biological tissue. These mesostructured aggregates of collagen isolated from biological tissues retain these inherent organizational features to enable their use as building blocks for constructing new collagen materials with ideal mechanical performance, thermal and dimensional stability. This strategy is distinct from the more common bottom-up or molecular-level design and assembly approach to generating collagen materials. The present review introduces the hierarchical structure of biological collagen with a focus on mesostructural features. Isolation strategies for these collagen aggregates (CAs) are summarized. Recent progress in the use of these mesostructural components for the construction of new collagen materials with emerging applications is reviewed, including in catalysis, environmental applications, biomedicine, food packaging, electrical energy storage, and flexible sensors. Finally, challenges and prospects are assessed for controllable production of CAs as well as material designs.
全文链接：https://authors.elsevier.com/sd/article/S0734-9750(23)00006-X
