史健翔，男，副教授，硕士生导师
地址：郑州市大学路40号郑州大学精准医学中心（河南省医药科学研究院代谢精准医学中心）
邮箱：jianxiangshi[at]zzu.edu.cn
电话：0371-66658223
邮编： 450052
学习及工作经历 ：
2024.12-至今：郑州大学河南省医药科学研究院代谢精准医学中心 副教授
2018.07-2024.12：郑州大学河南省医药科学研究院代谢精准医学中心 讲师
2014.09-2016.09：美国德克萨斯大学埃尔帕索分校 联合培养博士
2013.09-2018.06：郑州大学公共卫生学院 流行病与卫生统计学 医学博士
2011.09-2013.08：郑州大学公共卫生学院 流行病与卫生统计学 硕士阶段
2009.07-2011.08：郑州大学公共卫生学院 本科生辅导员
2004.09-2009.07：郑州大学公共卫生学院 预防医学 医学学士
研究方向：
1. 肿瘤生物信息学（单细胞转录组、空间转录组、单细胞多组学等）
2. 肿瘤免疫治疗新方法和新技术
3. 肿瘤免疫学诊断标志物筛选、鉴定和评价
4. 蛋白表达纯化和单克隆抗体制备
学术兼职：
河南省感染与分子免疫学专业委员会常务委员
青年委员会副秘书长
中国研究型医学会临床数据与样本资源库专业委员会委员
河南省抗癌协会肿瘤分子医学专业委员会委员
担任Frontiers in Oncology编委
BMC Cancer、Hereditas、Frontiers in Genetics、Current Medical Science、Cancer Medicine等杂志审稿人
主持项目：
1. 共性肿瘤新抗原疫苗与肿瘤特异性T细胞表面受体产品研发，横向项目，2023/10~2024/12, 100万元，主持，在研。
2. 国家药品监督管理局体外诊断试剂质量控制重点实验室开放课题，2024.07-2025.12，纵向项目，5万元，主持，在研。
3. 郑州大学河南省医药科学研究院2024年度基本科研业务费， 2024BP0207，4万元，主持
4. 2022年河南省高层次人才国际化培养项目，2022-2023，10万元，主持，已结题
5. 郑州大学河南省医药科学研究院2022年度基本科研业务费，2022BP0112，6万元，主持
6. 2019年度河南省重点研发与推广专项（科技攻关），项目编号：192102310034，立项支持，主持，已结题
7. 郑州大学青年教师科研启动费（优秀博士），2018-2020，10万，主持
8. 郑州大学河南省医药科学研究院2019年度基本业务费，2019BP0202，4万，主持，已结题
参与项目：
1. 去泛素化酶USP8调控CDK12介导的DNA同源重组修复在食管鳞癌化疗敏感性中的作用及机制研究，国自然面上项目基金，2022/01~2025/12，52万元，参与，在研。
2. 乙肝相关肝癌早期免疫诊断关键技术研发和应用，科技部重大专项（项目编号：2018ZX10302205-004），2018/01~2020/12，1041.72万元，参与（学术骨干及项目协调员），已结题
3.基于二代测序的新型冠状病毒变异、毒力分析和疫情监控研究，河南省科技厅新型冠状病毒应急科技攻关项目（项目编号：201100312100），2020-03至2021-03，50万元，参加（主要参与者及项目协调员），已结题
4. 肿瘤相关抗原抗体系统用于食管癌早期免疫诊断的评价和研究，国家自然科学基金面上项目（项目编号：81372371），2014/01-2017/12，70万元，参与，已结题
5. 卵巢癌早期免疫诊断标志物的鉴定、筛选和评价，国家自然科学基金面上项目（项目编号：81172086），2012/01-2015/12，60万元，参与，已结题
6. 肿瘤相关抗原的分子鉴定及其作为肝癌早期诊断标志物的研究，国家自然科学基金面上项目（项目编号：30872962），2009/01-2011/12，33万元，参与，已结题
发表学术论文
作为第一作者（含并列第一作者）发表学术论文
1. Binglei Zhang#, Jianxiang Shi#, Xiaojing Shi#, Xiaolu Xu, Le Gao, Song Li, Mengmeng Liu, Mengya Gao, Shuiling Jin Jian Zhou, Dandan Fan, Fang Wang, Zhenyu Ji, Zhilei Bian, Yongping Song, Wenzhi Tian Yichao Zheng*, Linping Xu*, Wei Li*. Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy. Drug Resistance Updates. 2024,74,101068 (#：并列第一作者)
2. Xinyue Hou#, Jianxiang Shi#, Jie Zhang#, Zhigang Wang, Sen Zhang, Ruifeng Li, Wei Jiang, Tingting Huang, Jiancheng Guo*, Wenjun Shang*. Treatment of acute kidney injury using a dual enzyme embedded zeolitic imidazolate frameworks cascade that catalyzes in vivo reactive oxygen species scavenging. Frontiers in Bioengineering and Biotechnology. 2022 Jan 4;9:800428. (#：并列第一作者)
3. Xia Xue#, Jianxiang Shi#, Hongen Xu#, Yaping Qin, Zengguang Yang, Shuaisheng Feng, Danhua Liu, Liguo Jian, Linlin Hua, Yaohe Wang, Qi Zhang, Xueyong Huang, Xiaoju Zhang, Xinxin Li, Chunguang Chen, Jiancheng Guo*, Wenxue Tang*, Jianbo Liu*. Binding Ability Prediction between Spike Protein and Human ACE2 Reveals the Adaptive Strategy of SARS-CoV-2 in Humans. Scientific Reports. 2021,11 (1):3187 (#：并列第一作者)
4. Qinge Shan#, Jianxiang Shi#, Xiaohui Wang, Jun Guo, Xiao Han, Zhehai Wang, Haiyong Wang*. A new nomogram and risk classification system for predicting survival in small cell lung cancer patients diagnosed with brain metastasis: a large population-based study. BMC cancer. 2021,21(1):640. (#：并列第一作者)
5. Xiaoling Shang#, Jianxiang Shi#, Xiaohui Wang, Chenglong Zhao, Haining Yu, Haiyong Wang*. A clinical variable‐based nomogram could predict the survival for advanced NSCLC patients receiving second‐line atezolizumab. Cancer Medicine. 2021,10(18):6218-26. (#：并列第一作者)
6. Hao Sun#, Jianxiang Shi#, Hongfei Zhang, Mengtao Xing, Pei Li, Liping Dai, Chenglin Luo, Xiao Wang, Peng Wang, Hua Ye, Liuxia Li, Jian-Ying Zhang. Serum autoantibodies against a panel of 15 tumor-associated antigens in the detection of ovarian cancer. Tumor Biology, 2017, 39(6):1010428317699132. (#：并列第一作者)
7. Li, Pei#, Jian-Xiang Shi#, Meng-Tao Xing, Li-Ping Dai, Ji-Tian Li, and Jian-Ying Zhang. Evaluation of serum autoantibodies against tumor-associated antigens as biomarkers in lung cancer. Tumor Biology 39, no. 10 (2017): 1010428317711662. (#：并列第一作者)
8. Pei Li#, Jianxiang Shi#, Liping Dai, Yurong Chai, Hongfei Zhang, Mutombo Kankonde, Peggy Kankonde, Baofa Yu, Jian-Ying Zhang. Serum anti-MDM2 and anti-c-Myc autoantibodies as biomarkers in the early detection of lung cancer. Oncoimmunology. 2016, 5(5): e1138200. (#：并列第一作者)
9. Jianxiang Shi#, Jiejie Qin#, Hua Ye, Peng Wang, Kaijuan Wang, Jian-Ying Zhang. Tumor associated antigens or anti-TAA autoantibodies as biomarkers in the diagnosis of ovarian cancer: a systematic review with meta-analysis. Expert review of molecular diagnostics. 2015, 15(6):829-52.
10. Yougai Zhang#, Jianxiang Shi#, Chunhua Song, Peng Wang, Liping Dai, Jian-Ying Zhang, Jiachen Shi. Association of mir-499 and mir-149 Polymorphisms with Cancer Risk in the Chinese Population: Evidence from Published Studies. Asian Pacific journal of cancer prevention, 2012, 14(4): 2337-42. (#：并列第一作者)
作为通讯作者发表学术论文
1. Wei Li, Binglei Zhang, Weijie Cao, Wenli Zhang, Tiandong Li, Lina Liu, LinPing Xu, Fengcai Gao, Yanmei Wang, Fang Wang, Haizhou Xing, Zhongxing Jiang, Jianxiang Shi*, Zhilei Bian*, Yongping Song*. Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing. Experimental Hematology & Oncology. 2023,12(1):44 (*：第一通讯作者)
2. Wei Li*, Tiandong Li, Chenguang Sun, Yimeng Du, Linna Chen, Chunyan Du*, Jianxiang Shi*, Weijie Wang*. Identification and prognostic analysis of biomarkers to predict the progression of pancreatic cancer patients. Molecular Medicine. 2022,28(1):43. (*：共同通讯作者)
3. Yaru Duan, Chi Cui, Cuipeng Qiu, Xiao Wang, Peng Wang, Hua Ye, Liping Dai, Jianxiang Shi*. Serum Autoantibodies against LRDD, STC1, and FOXA1 as Biomarkers in the Detection of Ovarian Cancer. Disease Markers. 2022 (*：通讯作者)
4. Chi Cui, Yaru Duan, Cuipeng Qiu, Peng Wang, Guiying Sun, Hua Ye, Liping Dai, Zhuo Han, Chunhua Song, Kaijuan Wang, Jianxiang Shi*, Jianying Zhang*. Identification of novel autoantibodies based on the human proteomic chips and evaluation of their performance in the detection of gastric cancer. Frotiers in Oncology. 2021,11:637871 (*：共同通讯作者)
5. Junkui Sun, Hongen Xu, Muge Qi, Chi Zhang*, Jianxiang Shi*. Identification of key genes in osteosarcoma by meta‑analysis of gene expression microarray. Molecular medicine reports. 2019 Oct 1;20(4):3075-84. (*：共同通讯作者)
6. Ping Chen, Jing-Yang Zhang, Bei-Bei Sha, Yan-Er Ma, Tao Hu, Yang-Cheng Ma, Hao Sun, Jian-Xiang Shi*, Ziming Dong*, Pei Li*. Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450. Oncotarget, 2017, 8(16):27471. （*：共同通讯作者）
合作作者发表论文
1. Tiandong Li, Guiying Sun, Hua Ye, Caijuan Song, Yajing Shen, Yifan Cheng, Yuanlin Zou, Zhaoyang Fang, Jianxiang Shi, Keyan Wang, Liping Dai, Peng Wang. ESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles. British Journal of Cancer. 2024,131(5):883-94
2. Qing Li, Haiyan Liu, Han Wang, Wenzhuo Xiong, Liping Dai, Xiuzhi Zhang, Peng Wang, Hua Ye, Jianxiang Shi, Zhihao Fang, Keyan Wang. Anti-BIRC5 autoantibody serves as a valuable biomarker for diagnosing AFP-negative hepatocellular carcinoma. PeerJ, 2024,12: e17494
3. Yuanlin Zou, Jicun Zhu, Caijuan Song, Tiandong Li, Keyan Wang, Jianxiang Shi, Hua Ye, Peng Wang. A polygenetic risk score combined with environmental factors better predict susceptibility to hepatocellular carcinoma in Chinese population. Cancer Medicine, 2024,13(9):e7230
4. Yifan Cheng, Qing Li, Guiying Sun, Tiandong Li, Yuanlin Zou, Hua Ye, Keyan Wang, Jianxiang Shi, Peng Wang. Serum anti-CFL1, anti-EZR, and anti-CYPA autoantibody as diagnostic markers in ovarian cancer. Scientific Reports. 2024,14(1):9757
5. Yajing Shen, Junfen Xia, Chuncheng Yi, Tiandong Li, Peng Wang, Liping Dai, Jianxiang Shi, Keyan Wang, Changqing Sun, Hua Ye. The association between circulating 25-hydroxyvitamin D and pancreatic cancer: A systematic review and meta-analysis of observational studies. European Journal of Nutrition. 2024,63(3): 653-672
6. Jiangpeng Pan, Yongliang Jia, Jianxiang Shi, Ruinan Yao, Jiancheng Guo. The efficacy and safety of compound kushen injection for adults with esophageal cancer: A meta-analysis of randomized controlled trials. Journal of Ethnopharmacology. 2024, 322:177604
7. Yulin Wang, Songyun Ouyang, Man Liu, Qiufang Si, Xue Zhang, Xiuzhi Zhang, Jiaqi Li, Peng Wang, Hua Ye, Jianxiang Shi, Chunhua Song, Kaijuan Wang, Liping Dai. Humoral immune response to tumor-associated antigen Ubiquilin 1 (UBQLN1) and its tumor-promoting potential in lung cancer. BMC cancer. 2024,24(1):283
8. Guiying Sun, Hua Ye, Huijuan Liu, Tiandong Li, Jiaxin Li, Xiaoyue Zhang, Yifan Cheng, Keyan Wang, Jianxiang Shi, Liping Dai, Peng Wang. ZPR1 is an immunodiagnostic biomarker and promotes tumor progression in esophageal squamous cell carcinoma. Cancer Science. 2024,115(1):70-82
9. Tiandong Li, Peng Wang, Guiying Sun, Yuanlin Zou, Yifan Cheng, Han Wang, Yin Lu, Jianxiang Shi, Keyan Wang, Qiang Zhang, Hua Ye. hccTAAb Atlas: An Integrated Knowledge Database for Tumor-Associated Autoantibodies in Hepatocellular Carcinoma. Journal of Proteome Research. 2024,23(2): 728-737
10. Keyan Wang, Cuipeng Qiu, Mengtao Xing, Miao Li, Bofei Wang, Hua Ye, Jianxiang Shi, Liping Dai, Xiao Wang, Peng Wang. Association of elevated autoantibody to high expression of GNAS in hepatocellular carcinoma. Heliyon. 2023,9(12): e22627
11. Guiying Sun, Huili Chen, Junfen Xia, Tiandong Li, Hua Ye, Jiaxin Li, Xiaoyue Zhang, Yifan Cheng, Keyan Wang, Jianxiang Shi, Peng Wang. Diagnostic performance of anti-MAGEA family protein autoantibodies in esophageal squamous cell carcinoma. International Immunopharmacology, 2023,125: 111041
12. Tiandong Li, Junfen Xia, Huan Yun, Guiying Sun, Yajing Shen, Peng Wang, Jianxiang Shi, Keyan Wang, Hongwei Yang, Hua Ye. A novel autoantibody signatures for enhanced clinical diagnosis of pancreatic ductal adenocarcinoma. Cancer Cell International. 2023,23(1):273
13. Guiying Sun, Hua Ye, Qian Yang, Jicun Zhu, Jianxiang Shi, Liping Dai, Keyan Wang, Jianying Zhang, Peng Wang. Using proteome microarray and gene expression omnibus database to screen tumour-associated antigens to construct the optimal diagnostic model of oesophageal squamous cell carcinoma. Clinical Oncology. 2023,35(10):e582-e592
14. Wenjuan Fan, Weijie Cao, Jianxiang Shi, Fengcai Gao, Meng Wang, Linping Xu, Fang Wang, Yingmei Li, Rong Guo, Zhilei Bian, Wei Li, Zhongxing Jiang, Wang Ma. Contributions of bone marrow monocytes/macrophages in myeloproliferative neoplasms with JAK2V617F mutation. Annals of Hematology. 2023,102(7):1745-1759.
15. Qian Yang, Hua Ye, Guiying Sun, Keyan Wang, Liping Dai, Cuipeng Qiu, Jianxiang Shi, Jicun Zhu, Xiao Wang, Peng Wang. Human Proteome Microarray identifies autoantibodies to tumor‐associated antigens as serological biomarkers for the diagnosis of hepatocellular carcinoma. Molecular oncology. 2023,17(5):887-900
16. Shuiling Jin, Ruihua Zhao, Chuang Zhou, Qian Zhong, Jianxiang Shi, Chang Su, Qinglong Li, Xiaoxing Su, Huabin Chi, Xu Lu, Guozhong Jiang, Renyin Chen, Jinming Han, Miao Jiang, Shishi Qiao, Jingjing Liu, Min Song, Lijie Song, Yabing Du, Zhiwei Chang, Meng Wang, Meilian Dong, Yali Zhong, Pu Yu, Xiaojian Zhang, Hong Zong. Feasibility and tolerability of sintilimab plus anlotinib as the second-line therapy for patients with advanced biliary tract cancers: An open-label, single-arm, phase II clinical trial. International Journal of Cancer. 2023,152(8):1648-1658.
17. Yulin Wang, Jiaqi Li, Xue Zhang, Man Liu, Longtao Ji, Ting Yang, Kaijuan Wang, Chunhua Song, Peng Wang, Hua Ye, Jianxiang Shi, Liping Dai. Autoantibody signatures discovered by HuProt protein microarray to enhance the diagnosis of lung cancer. Clinical Immunology. 2023,246:109206
18. Weijie Cao, Wenjuan Fan, Fang Wang, Yinyin Zhang, Guanghua Wu, Xiaojing Shi, Jianxiang Shi, Fengcai Gao, Meimei Yan, Rong Guo, Yingmei Li, Wei Li, Chunyan Du, Zhongxing Jiang. GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages. Journal of Translational Medicine. 2022, 20:1-17
19. Miao Jiang, Yongliang Jia, Jinming Han, Jianxiang Shi, Chang Su, Rui Zhang, Menglu Xing, Shuiling Jin, Hong Zong. Distinct clinical pattern of colorectal cancer patients with POLE mutations: a retrospective study on real-world data. Frontiers in Genetics. 2022, 13:963964
20. Chuncheng Yi, Tiandong Li, Yajing Shen, Peng Wang, Liping Dai, Jianxiang Shi, Keyan Wang, Changqing Sun, Hua Ye. Polymorphisms of nucleotide excision repair genes associated with colorectal cancer risk: Meta-analysis and trial sequential analysis. Frontiers in Genetics. 2022, 13:1009938.
21. Yaxin Sun, Beibei Sha, Wenjing Huang, Miaomiao Li, Shan Zhao, Yuan Zhang, Jie Yan, Zheng Li, Jingwen Tang, Peiyan Duan, Jianxiang Shi, Pei Li, Tao Hu, Ping Chen. ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells. Apoptosis. 2022, 27(7):545-560
22. Zhu, Jicun, Peng Wang, Hua Ye, Jianxiang Shi, Xiao Wang, Keyan Wang, Fujiao Duan, Qian Yang, Guiying Sun, and Jianying Zhang. Trend of the mortality of major liver diseases and its impact on life expectancy in China from 2006 to 2017. Journal of Public Health. 2022,44(1):100-110
23. Jinyu Wu, Peng Wang, Zhuo Han, Tiandong Li, Chuncheng Yi, Cuipeng Qiu, Qian Yang, Guiying Sun, Liping Dai, Jianxiang Shi, Keyan Wang, Hua Ye. A novel immunodiagnosis panel for hepatocellular carcinoma based on bioinformatics and the autoantibody-antigen system. Cancer Science. 2022,113(2):411-422
24. Zhuo Yang, Nan Hu, Weiwei Wang, Weihua Hu, Shaolong Zhou, Jianxiang Shi, Minghe Li, Zhou Jing, Chao Chen, Xuyang Zhang, Ruyi Yang, Xudong Fu, Xinjun Wang. Loss of FBXW7 correlates with increased IDH1 expression in glioma and enhances IDH1-mutant cancer cell sensitivity to radiation. Cancer research. 2022, 82(3):497-509
25. Keming Li, Zhuo Han, Jinyu Wu, Hua Ye, Guiying Sun, Jianxiang Shi, Jianying Zhang, Peng Wang. The Relationship between MALAT1 Polymorphism rs3200401 C > T and the Risk of Overall Cancer: A Meta-Analysis. Medicina. 2022, 58(2):176.
26. Beibei Sha, Yaxin Sun, Shan Zhao, Miaomiao Li, Wenjing Huang, Zheng Li, Jianxiang Shi, Xuefei Han, Pei Li, Tao Hu, Ping Chen. USP8 inhibitor–induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma. Cell Biology and Toxicology. 2022, 13:1-22
27. Jinming Han, Jianxiang Shi, Miao Jiang, Ruowen Zhang, Shuiling Jin, Yongliang Jia, Hong Zong. Clinical Characteristics and Prognostic Values of PIK3CA Mutation in Colorectal Cancer Patients. 2022, 6(1):121-132
28. Miao Jiang, Shuiling Jin, Jinming Han, Tong Li, Jianxiang Shi, Qian Zhong, Wen Li, Wenxue Tang, Qinqin Huang, Hong Zong. Detection and clinical significance of circulating tumor cells in colorectal cancer. Biomarker research. 2021, 9:1-20
29. Zhuo Han, Keming Li, Jinyu Wu, Keyan Wang, Cuipeng Qiu, Hua Ye, Chi Cui, Chunhua Song, Kaijuan Wang, Jianxiang Shi, Peng Wang, Jianying Zhang. Diagnostic value of RNA for hepatocellular carcinoma: a network meta-analysis. Biomarkers in medicine. 2021,15(18):1755-1767
30. Huimin Wang, Xiaoang Yang, Guiying Sun, Qian Yang, Chi Cui, Xiao Wang, Hua Ye, Liping Dai, Jianxiang Shi, Jianying Zhang, Peng Wang. Identification and evaluation of autoantibody to a novel tumor-associated antigen GNA11 as a biomarker in esophageal squamous cell carcinoma. Frontiers in Oncology. 2021, 11:661043
31. Meng Zhang, Yaoguang Li, Zihao Fan, Dongqi Shen, Xueying Huang, Qi Yu, Mei Liu, Feng Ren, Xiao Wang, Liping Dai, Peng Wang, Hua Ye, Jianxiang Shi, Xiaoang Yang, Shunxiang Zhang, Jianying Zhang. Assessing health-related quality of life and health utilities in patients with chronic hepatitis B-related diseases in China: a cross-sectional study. BMJ open. 2021, 11(9):e047475
32. Cuipeng Qiu, Yaru Duan, Bofei Wang, Jianxiang Shi, Peng Wang, Hua Ye, Liping Dai, Jianying Zhang, Xiao Wang. Serum anti-PDLIM1 autoantibody as diagnostic marker in ovarian cancer. Frontiers in Immunology. 2021, 12:698312
33. Cuipeng Qiu, Bofei Wang, Peng Wang, Xiao Wang, Yan Ma, Liping Dai, Jianxiang Shi, Keyan Wang, Guiying Sun, Hua Ye, Jianying Zhang. Identification of novel autoantibody signatures and evaluation of a panel of autoantibodies in breast cancer. Cancer science. 2021, 112(8):3388-3400
34. Yulin Wang, Peng Wang, Man Liu, Xue Zhang, Qiufang Si, Ting Yang, Hua Ye, Chunhua Song, Jianxiang Shi, Kaijuan Wang, Xiao Wang, Jianying Zhang, Liping Dai. Identification of tumor-associated antigens of lung cancer: SEREX combined with bioinformatics analysis. Journal of Immunological Methods. 2021, 492:112991
35. Di Jiang, Xue Zhang, Man Liu, Yulin Wang, Tingting Wang, Lu Pei, Peng Wang, Hua Ye, Jianxiang Shi, Chunhua Song, Kaijuan Wang, Xiao Wang, Liping Dai, Jianying Zhang. Discovering panel of autoantibodies for early detection of lung cancer based on focused protein array. Frontiers in immunology, 2021, 12:658922
36. Hua Ye, Tiandong Li, Hua Wang, Jinyu Wu, Chuncheng Yi, Jianxiang Shi, Peng Wang, Chunhua Song, Liping Dai, Guozhong Jiang, Yuxin Huang, Yongwei Yu, Jitian Li. TSPAN1, TMPRSS4, SDR16C5, and CTSE as Novel Panel for Pancreatic Cancer: A Bioinformatics Analysis and Experiments Validation. Frontiers in Immunology. 2021, 12:649551
37. Yan Ma, Xiao Wang, Cuipeng Qiu, Jiejie Qin, Keyan Wang, Guiying Sun, Di Jiang, Jitian Li, Lin Wang, Jianxiang Shi, Peng Wang, Hua Ye, Liping Dai, Bing‐Hua Jiang, Jianying Zhang. Using protein microarray to identify and evaluate autoantibodies to tumor-associated antigens in ovarian cancer. Cancer Science. 2021, 112(2):537-549
38. Longhao Wang#, Miaomiao Li#, Beibei Sha, Xuanyu Hu, Yaxin Sun, Mingda Zhu, Yan Xu, Pingping Li, Yating Wang, Yanyan Guo, Jiangfeng Li, Jiangxiang Shi, Pei Li, Tao Hu*, Ping Chen*. Inhibition of deubiquitination by PR-619 induces apoptosis and autophagy via ubi-protein aggregation-activated ER stress in esophageal squamous cell carcinoma. Cell Proliferation. 2021, 54 (1):e12919
39. Shuiling Jin, Lanling Weng, Zhi Li, Zhenzhen Yang, Lili Zhu, Jianxiang Shi, Wenxue Tang, Wang Ma*, Hong Zong*, Wei Jiang*. Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy. Journal of Materials Chemistry B, 2020, 8(21):4620-26.
40. Yinchao Li, Nana Li, Jianxiang Shi, Tanzeel Ahmed, Hongmin Liu, Jiancheng Guo, Wenxue Tang, Yongjun Guo, Qi Zhang. Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells. Frontiers in Oncology, 2020, 9:1525.
41. Guiying Sun, Hua Ye, Xiao Wang, Lin Cheng, Pengfei Ren, Jianxiang Shi, Liping Dai, Peng Wang, Jianying Zhang. Identification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinoma. OncoImmunology, 2020, 9(1):1814515.
42. Keyan Wang, Miao Li, Jiejie Qin, Guiying Sun, Liping Dai, Peng Wang, Hua Ye, Jianxiang Shi, Lin Cheng, Qian Yang, Cuipeng Qiu, Di Jiang, Xiao Wang, Jianying Zhang*. Serological Biomarkers for Early Detection of Hepatocellular Carcinoma: A Focus on Autoantibodies against Tumor-Associated Antigens Encoded by Cancer Driver Genes. Cancers, 2020, 12(5):1271.
43. Guiying Sun, Hua Ye, Xiao Wang, Tiandong Li, Di Jiang, Cuipeng Qiu, Liping Dai, Jianxiang Shi, Kaijuan Wang, Chunhua Song, Peng Wang, Jianying Zhang. Autoantibodies against tumor‐associated antigens combined with microRNAs in detecting esophageal squamous cell carcinoma. Cancer Medicine. 2020, 9(3):1173-82.
44. Huan Luo, Peng Wang, Hua Ye, Jianxiang Shi, Liping Dai, Xiao Wang, Chunhua Song, Jianying Zhang, Jitian Li. Serum-derived microRNAs as prognostic biomarkers in osteosarcoma: a meta-analysis. Frontiers in Genetics. 2020;11:789.
45. Mengtao Xing, Pei Li, Xiao Wang, Jitian Li, Jianxiang Shi, Jiejie Qin, Xiaojun Zhang, Yangcheng Ma, Giulio Francia, Jian-Ying Zhang. Overexpression of p62/IMP2 can Promote Cell Migration in Hepatocellular Carcinoma via Activation of the Wnt/β-Catenin Pathway. Cancers. 2020,12(1):7.
46. Cuipeng Qiu, Peng Wang, Bofei Wang, Jianxiang Shi, Xiao Wang, Tiandong Li, Jiejie Qin, Liping Dai, Hua Ye, Jianying Zhang. Establishment and validation of an immunodiagnostic model for prediction of breast cancer. Oncoimmunology. 2020,9(1):1682382.
47. Di Jiang, Yulin Wang, Man Liu, Qiufang Si, Tingting Wang, Lu Pei, Peng Wang, Hua Ye, Jianxiang Shi, Xiao Wang, Chunhua Song, Kaijuan Wang, Liping Dai, Jianying Zhang. A panel of autoantibodies against tumor-associated antigens in the early immunodiagnosis of lung cancer. Immunobiology. 2020,225(1):151848.
48. Beibei Sha, Xiaoyu Chen, Han Wu, Miaomiao Li, Jianxiang Shi, Longhao Wang, Xingge Liu, Ping Chen, Tao Hu, Pei Li. Deubiquitylatinase inhibitor b-AP15 induces c-Myc-Noxa-mediated apoptosis in esophageal squamous cell carcinoma. Apoptosis. 2019, 24(9-10):826-36.
49. Tian-Dong Li, Hong-Wei Yang, Peng Wang, Chun-Hua Song, Kai-Juan Wang, Li-Ping Dai, Jian-Xiang Shi, Jian-Ying Zhang, Hua Ye. Coffee consumption and risk of pancreatic cancer: a systematic review and dose–response meta-analysis. International journal of food sciences and nutrition. 2019, 70(5):519-29.
50. Jiejie Qin, Shuaibing Wang, Jianxiang Shi, Yan Ma, Keyan Wang, Hua Ye, Xiaojun Zhang, Peng Wang, Xiao Wang, Chunhua Song, Liping Dai, Kaijuan Wang, Binghua Jiang, Jianying Zhang. Using recursive partitioning approach to select tumor‐associated antigens in immunodiagnosis of gastric adenocarcinoma. Cancer Science. 2019, 110(6):1829.
51. Shuaibing Wang, Jiejie Qin, Hua Ye, Keyan Wang, Jianxiang Shi, Yan Ma, Yitao Duan, Chunhua Song, Xiao Wang, Liping Dai, Kaijuan Wang, Peng Wang, Jianying Zhang. Using a panel of multiple tumor-associated antigens to enhance autoantibody detection for immunodiagnosis of gastric cancer. Oncoimmunology. 2018 Aug 3;7(8):e1452582.
52. Hongfei Zhang, Jiejie Qin, Pengfei Ren, Jianxiang Shi, Junfen Xia, Hua Ye, Peng Wang, Chunhua Song, Kaijuan Wang, Jianying Zhang. A panel of autoantibodies against multiple tumor-associated antigens in the immunodiagnosis of esophageal squamous cell cancer. Cancer immunology, immunotherapy. 2016, 65(10):1233-42.
53. Junfen Xia, Jianxiang Shi, Peng Wang, Chunhua Song, Kaijuan Wang, Jianying Zhang, Hua Ye. Tumour‐Associated Autoantibodies as Diagnostic Biomarkers for Breast Cancer: A Systematic Review and Meta‐Analysis. Scandinavian journal of immunology. 2016, 83(6):393-408.
54. Jiejie Qin, Xiaorui Wang, Peng Wang, Pengfei Ren, Jianxiang Shi, Hongfei Zhang, Junfen Xia, Kaijuan Wang, Chunhua Song, Liping Dai, Jian-Ying Zhang. Mini-array of multiple tumor-associated antigens (TAAs) in the immunodiagnosis of esophageal cancer. Asian Pacific journal of cancer prevention: APJCP. 2013, 15(6):2635-40.
55. Yuchun Li, Kaijuan Wang, Liping Dai, Peng Wang, Chunhua Song, Jianxiang Shi, Pengfei Ren, Hua Ye, Jian-Ying Zhang. HapMap-based study of CIP2A gene polymorphisms and HCC susceptibility. Oncology Letter. 2012, 4(2):358-64.
56. Shuaiyin Chen, Rongguang Zhang, Guangcai Duan, Jianxiang Shi. Grade Expression of Helicobacter pylori UreB Subunit in Lactococcus lactis and its Immunoreactivity. Current Microbiology. 2011, 62(6):1726-31
57. 李玉春，宋春花，杨文杰，代丽萍，王鹏，史健翔，张建营，王凯娟. 调控microRNA成熟的通路基因标签单核苷酸多态性与原发性肝癌易感性的关系. 中华预防医学杂志, 2012, 46(6):533-7.
会议摘要及壁报展示
1. Yu Xiao, Jianxiang Shi, Maharana Prathap R. Adama, Grace J. Kim, Meghan Welch, Yinan Jiang. The Dynamic Role of PPAR-γ and Related Pathways in Beta Cells during Type 2 Diabetes Mellitus Progression. Diabetes. 2024 Jun 14;73(Supplement_1). (会议摘要)
2. Hong Zong, Qian Zhong, Ruihua Zhao, Shuiling Jin, Chuang Zhou, Xiaojian Zhang, Jianxiang Shi, Shishi Qiao, Jinming Han, Miao Jiang. Phase II study of anlotinib plus sintlimab as second-line treatment for patients with advanced biliary tract cancers. Journal of Clinical Oncology. 2021: 39 (3_suppl), 307-307. (会议摘要)
3. Jianxiang Shi, Chi Cui, Yaru Duan, Hua Ye, Peng Wang, Jitian Li, Shuiling Jin, Liping Dai, Jianying Zhang. Construction of ce-RNA networks and comprehensive analysis with tumor infiltrating immune cells in hepatocellular carcinoma. 110th AACR Annual Meeting; 2020. (会议摘要 )
4. Mengtao Xing, Jianxiang Shi, Pei Li, Jiejie Qin, Xiaojun Zhang, Yangcheng Ma, Xiao Wang, Giulio Francia, Jianying Zhang. Overexpression of p62/IMP2 can promote cell migration in hepatocellular carcinoma (HCC) via activating Wnt/β-catenin pathway. 109th AACR Annual Meeting; Atlanta, GA, March 29-April 3, 2019. (会议摘要 )
5. Mengtao Xing, Jianxiang Shi, Jitian Li, Beibei Chen, Giulio Francia and Jianying Zhang. P62/IMP2 promotes metastasis in hepatocellular carcinoma (HCC) by regulating EMT in different signaling pathway. 108th AACR Annual Meeting, Chicago, IL, April 14-18, 2018. (会议摘要)
6. Jianxiang Shi, Mengtao Xing, Chenglin Luo, Xiao Wang, Liping Dai and Jianying Zhang. Revisiting TCGA data identifies key genes in lung adenocarcinoma. 108th AACR Annual Meeting, Chicago, IL, April 14-18, 2018. (会议摘要)
7. Jianxiang Shi, Hao Sun, Hongfei Zhang, Mengtao Xing, Jitian Li, Pei Li, Liping Dai, Chenglin Luo, Jian-Ying Zhang. Systematic discovery of biomarkers for ovarian cancer by using the Human Protein Atlas database. 107th AACR Annual Meeting, New Orleans, Louisiana, USA, 2016.04.16-04.20. (壁报展示和会议摘要)
所获荣誉
1. 史健翔（4/10），食管癌自身抗体血清学早期诊断技术体系的建立及应用， 河南省科学技术进步奖，二等奖，2024年（2024-J-165-R04/10）
2. 史健翔（8/10），基于自身抗体的乳腺癌和卵巢癌早期诊断标志物发现和应用，河南省科学技术进步奖，二等奖，2023年（2023-J-155-R08/10）
3. 史健翔（8/13），中原人群药物基因数据库的建立及其在药物毒副作用精准检测中的应用，中国医药教育协会科学技术奖，二等奖，2023年（2023KCY-D2-22-08）
4. 史健翔（5/10），肿瘤相关抗原抗体系统用于肺癌早期免疫诊断的评价，河南省科学技术进步奖，二等奖，2020年（2019-J-109-R05/10）
5. 史健翔（6/13），肿瘤相关抗原抗体系统用于食管癌早期免疫诊断的评价和研究，河南省科学技术厅，科学技术成果，2018年8月
6. 史健翔（10/14），肿瘤相关抗原的分子鉴定与评价在肝癌早期免疫诊断中的应用，河南省卫生和计划生育委员会，河南省医学科学进步奖，二等奖，2016年
专利和软著
1. 国家发明专利：史健翔;王科妍;韩卓;易春程;王鹏;叶华;代丽萍，PRKCZ自身抗体在食管鳞癌辅助诊断中的应用， ZL 2021 1 1096016.3，2023年7月7日，
2. 软件著作权：史健翔，邱赞，王新威，彭雷。基于机器学习和血清分子标志物的结直肠癌辅助诊断预测软件（V1.0），软著登字第14223069号，2024年11月18日
教改项目及学科竞赛
1. “精准医学课程体系建设”项目1项，项目编号：A-YXC20200101-16参与，
2. 参与医药学研究生在线教育平台在线开放课程《精准医学基础》录制（CMGE20220011）
3. 指导研究生参加“兆易创新杯”第十六届中国研究生电子设计竞赛商业计划书专项赛初赛团队一等奖，NLOS声学：基于MEMS传声器的车载定位避障系统，中国学位与研究生教育学会、中国科协青少年科技中心、中国电子学会，编号：GEDC-02210400671，指导老师：史健翔、王晓霞
