史健翔，男，讲师，硕士生导师
地址：郑州市大学路40号郑州大学精准医学中心（河南省医药科学研究院代谢精准医学中心）
邮箱：jianxiangshi@zzu.edu.cn
电话：0371-61730291
邮编： 450052
学习及工作经历 ：
2018.7-至今：郑州大学河南省医药科学研究院代谢精准医学中心 讲师
2014.9-2016.9：美国德克萨斯大学埃尔帕索分校 联合培养博士
2013.9-2018.6：郑州大学公共卫生学院 流行病与卫生统计学 医学博士
2011.9–2013.8：郑州大学公共卫生学院 流行病与卫生统计学 硕士阶段
2009.7-2011.8：郑州大学公共卫生学院 本科生辅导员
2004.9-2009.7：郑州大学公共卫生学院 预防医学 医学学士
研究方向：
1. 肿瘤生物信息学（单细胞转录组、空间转录组、单细胞多组学等）
2. 肿瘤转移、复发、耐药相关机制研究
3. 肿瘤免疫学诊断标志物筛选、鉴定和评价
学术兼职：
河南省感染与分子免疫学专业委员会常务委员
青年委员会副秘书长
中国研究型医学会临床数据与样本资源库专业委员会委员
河南省抗癌协会肿瘤分子医学专业委员会委员
担任Frontiers in Oncology编委
BMC Cancer、Hereditas、Frontiers in Genetics、Current Medical Science、Cancer Medicine等杂志审稿人
主持项目：
1. 2022年河南省高层次人才国际化培养项目，2022-2023，10万，主持
2. 郑州大学河南省医药科学研究院2022年度基本科研业务费，2022BP0112，6万，主持
3. 2019年度河南省重点研发与推广专项（科技攻关），项目编号：192102310034，立项支持，主持，已结题
4. 郑州大学青年教师科研启动费（优秀博士），2018-2020，10万，主持
5. 郑州大学河南省医药科学研究院2019年度基本业务费，2019BP0202，4万，主持，已结题
参与项目：
1. 国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项，“乙肝相关肝癌早期免疫诊断关键技术研发和应用”，2018/01-2020/12，1041.72万元，参与，已结题
发表文章：
以通讯、第一作者身份发表文章：
#共同一作，*通讯作者
1. Li W*, Li TD, Sun CG, Du YM, Chen LN, Du CY, Shi JX*, Wang WJ*. Identification and prognostic analysis of biomarkers to predict the progression of pancreatic cancer patients. Molecular Medicine. 2022 Dec;28(1):1-6.
2. Duan YR, Cui C, Qiu CP, Sun GY, Wang X, Wang P, Ye H, Dai LP, Shi JX*. Serum Autoantibodies against LRDD, STC1, and FOXA1 as Biomarkers in the Detection of Ovarian Cancer. Disease Markers. 2022 Mar 1;2022.
3. Hou XY#, Shi JX#, Zhang J, Wang ZG, Zhang S, Li RF, Jiang W, Huang TT, Guo JC, Shang WJ. Treatment of Acute Kidney Injury Using a Dual Enzyme Embedded Zeolitic Imidazolate Frameworks Cascade That Catalyzes In Vivo Reactive Oxygen Species Scavenging. Frontiers in Bioengineering and Biotechnology. 2022 Jan 4;9:1324.
4. Xue X#, Shi JX#, Xu HE#, Qin YP, Yang ZG, Feng SS, Liu DH, Jian LG, Hua LL, Wang YH, Zhang Q, Huang XY, Zhang XJ, Li XX, Chen CG, Guo JC*, Tang WX*, Liu JB*. Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans. Scientific reports. 2021;11(1):1-2.
5. Cui C, Duan YR, Qiu CP, Wang P, Sun GY, Ye H, Dai LP, Han Z, Song CH, Wang KJ, Shi JX*, Zhang JY*. Identification of Novel Autoantibodies Based on the Human Proteomic Chips and Evaluation of Their Performance in the Detection of Gastric Cancer. Frontiers in oncology. 2021;11:342.
6. Sun JK, Xu H, Qi M, Zhang C*, Shi JX*. Identification of key genes in osteosarcoma by meta‑analysis of gene expression microarray. Molecular medicine reports. 2019;20(4):3075-84.
7. Chen P, Zhang JY, Sha BB, Ma YE, Hu T, Ma YC, Sun H, Shi JX*, Dong ZM*, Li P*. Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450. Oncotarget. 2017;8(16):27471.
8. Li P#, Shi JX#, Dai LP, Chai YR, Zhang HF, Kankonde M, Kankonde P, Yu BF, Zhang JY*. Serum anti-MDM2 and anti-c-Myc autoantibodies as biomarkers in the early detection of lung cancer. Oncoimmunology. 2016;5(5):e1138200.
9. Shi JX#, Qin JJ#, Ye H, Wang P, Wang KJ, Zhang JY*. Tumor associated antigens or anti-TAA autoantibodies as biomarkers in the diagnosis of ovarian cancer: a systematic review with meta-analysis. Expert review of molecular diagnostics. 2015;15(6):829-52.
合作发表文章（部分）：
1. Jiang M, Jia Y, Han J, Shi JX, Su C, Zhang R, Xing M, Jin S, Zong H. Distinct clinical pattern of colorectal cancer patients with POLE mutations: A retrospective study on real-world data. Molecular Basis of Epigenetic Regulation in Cancer Therapies. 2023 Feb 10;16648714:300.
2. Yang Q, Ye H, Sun G, Wang K, Dai L, Qiu C, Shi JX, Zhu J, Wang X, Wang P. Human Proteome Microarray identifies autoantibodies to tumor‐associated antigens as serological biomarkers for the diagnosis of hepatocellular carcinoma. Molecular Oncology. 2023 Jan 1.
3. Wang Y, Li J, Zhang X, Liu M, Ji L, Yang T, Wang K, Song C, Wang P, Ye H, Shi JX, Dai LP. Autoantibody signatures discovered by HuProt protein microarray to enhance the diagnosis of lung cancer. Clinical Immunology. 2023 Jan 1;246:109206.
4. Cao W, Fan W, Wang F, Zhang Y, Wu G, Shi X, Shi JX, Gao F, Yan M, Guo R, Li Y. GM-CSF impairs erythropoiesis by disrupting erythroblastic island formation via macrophages. Journal of Translational Medicine. 2022 Dec;20:1-7.
5. Jin S, Zhao R, Zhou C, Zhong Q, Shi JX, Su C, Li Q, Su X, Chi H, Lu X, Jiang G. Feasibility and tolerability of sintilimab plus anlotinib as the second‐line therapy for patients with advanced Biliary Tract Cancers: an open‐label, single‐arm, phase II clinical trial. International Journal of Cancer. 2022 Nov 28.
6. Yi CC, Li T, Shen Y, Wang P, Dai L, Shi JX, Wang KY, Sun CQ, Ye H*. Polymorphisms of nucleotide excision repair genes associated with colorectal cancer risk: Meta-analysis and trial sequential analysis. Frontiers in Genetics. 2022 Oct 31:3047.
7. Sun Y, Sha B, Huang W, Li M, Zhao S, Zhang Y, Yan J, Li Z, Tang J, Duan P, Shi JX, Li P, Hu T*, Chen P*. ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells. Apoptosis. 2022 Aug;27(7-8):545-60.
8. Zhu JC, Wang P, Ye H, Shi JX, Wang X, Wang K, Duan F, Yang Q, Sun GY, Zhang JY*. Trend of the mortality of major liver diseases and its impact on life expectancy in China from 2006 to 2017. Journal of Public Health. 2022 Mar;44(1):100-10.
9. Yang Z, Hu N, Wang WW, Hu WH, Zhou SL, Shi JX, Li MH, Jing Z, Chen C, Zhang XY, Yang RY, Fu XD*, Wang XJ*. Loss of FBXW7 Correlates with Increased IDH1 Expression in Glioma and Enhances IDH1-Mutant Cancer Cell Sensitivity to RadiationFBXW7 Loss Radiosensitizes IDH1-Mutant Cancer Cells. Cancer Research. 2022 Feb 1;82(3):497-509.
10. Wang YL, Wang P, Liu, M, Zhang, X, Si, Q, Yang, T, Ye, H, Song, CH, Shi, JX, Wang, KJ. and Wang X, Zhang JY*, Dai LP*, Identification of tumor-associated antigens of lung cancer: SEREX combined with bioinformatics analysis. Journal of Immunological Methods, 2021; 492, p.112991.
11. Ye H#, Li T#, Wang H, Wu J, Yi C, Shi JX, Wang P, Song C, Dai L, Jiang G, Huang YX, Yu YM*, Li JT*. TSPAN1, TMPRSS4, SDR16C5, and CTSE as Novel Panel for Pancreatic Cancer: A Bioinformatics Analysis and Experiments Validation. Frontiers in immunology. 2021;12:706.
12. Ma Y#, Wang X#, Qiu C, Qin J, Wang K, Sun G, Jiang D, Li J, Wang L, Shi JX, Wang P, Ye H, Dai LP, Jiang BH*, Zhang JY*. Using protein microarray to identify and evaluate autoantibodies to tumor-associated antigens in ovarian cancer. Cancer science. 2021;112(2):537.
13. Zhu JC, Wang P, Ye H, Shi JX, Wang X, Wang KY, Duan F, Yang Q, Sun GY, Zhang JY*. Trend of the mortality of major liver diseases and its impact on life expectancy in China from 2006 to 2017. Journal of Public Health. 2021 Jan 18.
14. Zhang X#, Jiang D#, Liu M, Wang YL, Wang TT, Lu P, Wang P, Ye H, Shi JX, Song CH, Wang KJ, Wang X, Dai LP*, Zhang JY*. Discovering panel of autoantibodies for early detection of lung cancer based on focused protein array. Frontiers in immunology. 2021;12.
15. Wang LH, Li MM, Sha BB, Hu XY, Sun YX, Zhu MD, Xu Y, Li PP, Wang YT, Guo YY, Li JF, Shi JX, Li P, Hu T, Chen P. Inhibition of deubiquitination by PR‐619 induces apoptosis and autophagy via ubi‐protein aggregation‐activated ER stress in oesophageal squamous cell carcinoma. Cell Proliferation. 202;54(1):e12919.
16. Xing M, Li P, Wang X, Li J, Shi JX, Qin J, Zhang X-J, Ma YC, Francia G*, Zhang J-Y*. Overexpression of p62/IMP2 can Promote Cell Migration in Hepatocellular Carcinoma via Activation of the Wnt/β-Catenin Pathway. Cancers. 2020;12(1):7.
17. Wang K, Li M, Qin J, Sun G, Dai L, Wang P, Ye H, Shi JX, Cheng L, Yang Q, Qiu CP, Jiang D, Wang X, Zhang J-Y*. Serological Biomarkers for Early Detection of Hepatocellular Carcinoma: A Focus on Autoantibodies against Tumor-Associated Antigens Encoded by Cancer Driver Genes. Cancers. 2020;12(5):1271.
18. Sun G#, Ye H#, Wang X, Li T, Jiang D, Qiu C, Dai LP, Shi JX, Wang KJ, Song CH, Wang P*, Zhang JY*. Autoantibodies against tumor‐associated antigens combined with microRNAs in detecting esophageal squamous cell carcinoma. Cancer Medicine. 2020;9(3):1173-82.
19. Sun G#, Ye H#, Wang X, Cheng L, Ren P, Shi JX, Dai LP, Wang P*, Zhang JY*. Identification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinoma. OncoImmunology. 2020;9(1):1814515.
20. Qiu C, Wang P, Wang B, Shi JX, Wang X, Li TD, Qin JJ, Dai LP, Ye H*, Zhang JY*. Establishment and validation of an immunodiagnostic model for prediction of breast cancer. Oncoimmunology. 2020;9(1):1682382.
21. Luo H, Wang P, Ye H, Shi JX, Dai L, Wang X, Song CH, Zhang JY*, Li JT*. Serum-derived microRNAs as prognostic biomarkers in osteosarcoma: a meta-analysis. Frontiers in Genetics. 2020;11:789.
22. Li YC, Li NN, Shi JX, Ahmed T, Liu HM, Guo JC, Tang WX, Guo YJ, Zhang Q*. Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells. Frontiers in Oncology. 2020;9:1525.
23. Jin SL, Weng LL, Li Z, Yang ZZ, Zhu LL, Shi JX, Tang WX, Ma W*, Zong H*, Jiang W*. Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy. Journal of Materials Chemistry B. 2020;8(21):4620-6.
24. Jiang D, Wang Y, Liu M, Si Q, Wang T, Pei L, Wang P, Ye H, Shi JX, Wang X, Song CH, Wang KJ, Dai LP*, Zhang JY*. A panel of autoantibodies against tumor-associated antigens in the early immunodiagnosis of lung cancer. Immunobiology. 2020;225(1):151848.
25. Sha BB, Chen XY, Wu H, Li MM, Shi JX, Wang LH, Liu XG, Chen P*, Hu T*, Li P*. Deubiquitylatinase inhibitor b-AP15 induces c-Myc-Noxa-mediated apoptosis in esophageal squamous cell carcinoma. Apoptosis. 2019;24(9-10):826-36.
26. Qin JJ, Wang SB, Shi JX, Ma Y, Wang K, Ye H, Zhang XJ, Wang P, Wang X, Song CH, Dai LP, Wang KJ, Zhang JY*. Using recursive partitioning approach to select tumor‐associated antigens in immunodiagnosis of gastric adenocarcinoma. Cancer Science. 2019;110(6):1829.
27. Li TD, Yang HW, Wang P, Song CH, Wang KJ, Dai LP, Shi JX, Zhang JY*, Ye H*. Coffee consumption and risk of pancreatic cancer: a systematic review and dose–response meta-analysis. International journal of food sciences and nutrition. 2019;70(5):519-29.
28. Zhang L, Dong B, Ren PF, Ye H, Shi JX, Qin J, Wang KJ, Wang P*, Zhang JY*. Circulating plasma microRNAs in the detection of esophageal squamous cell carcinoma. Oncology letters. 2018;16(3):3303-18.
29. Wang SB, Qin JJ, Ye H, Wang KY, Shi JX, Ma Y, Duan YT, Song CH, Wang X, Dai LP, Wang KJ, Wang P*, Zhang JY*. Using a panel of multiple tumor-associated antigens to enhance autoantibody detection for immunodiagnosis of gastric cancer. Oncoimmunology. 2018;7(8):e1452582.
30. Zhang HF, Qin JJ, Ren PF, Shi JX, Xia JF, Ye H, Wang P, Song CH, Wang KJ, Zhang JY*. A panel of autoantibodies against multiple tumor-associated antigens in the immunodiagnosis of esophageal squamous cell cancer. Cancer Immunology, Immunotherapy. 2016;65(10):1233-42.
31. Xia JF, Shi JX, Wang P, Song CH, Wang KJ, Zhang J*, Ye H*. Tumour‐associated autoantibodies as diagnostic biomarkers for breast cancer: a systematic review and meta‐analysis. Scandinavian journal of immunology. 2016;83(6):393-408.
