A multi-functional nanoplatform for efficacy tumor theranostic applications

【作者】 Jinjin Shi; Hongling Zhang; Zhaoyang Chen; Lihua Xu; Zhenzhong Zhang

【期刊名】 Asian Journal of Pharmaceutical Sciences

【影响因子】

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2017, 3: 235-249

【关键词】 Multifunctional drug delivery; Endosome escape; Tumor-targeting; Bio-imaging; Theranostic

【摘要】Nanomaterials with multiple functions have become more and more popular in the domain of cancer research. MoS2 has a great potential in photothermal therapy, X-ray/CT imaging and drug delivery. In this study, a water soluble MoS2 nanosystem (MoS2-PEG) was synthesized and explored in drug delivery, photothermal therapy (PTT) and X-ray imaging. Doxorubicin (DOX) was loaded onto MoS2-PEG with a high drug loading efficiency (~69%) and obtained a multifunctional drug delivery system (MoS2-PEG/DOX). As the drug delivery, MoS2-PEG/DOX could efficiently cross the cell membranes, and escape from the endosome via NIR light irradiation, lead to more apoptosis in MCF-7 cells, and afford higher antitumor efficacy without obvious toxic effects to normal organs owing to its prolonged blood circulation and 11.6-fold higher DTX uptake of tumor than DOX. Besides, MoS2-PEG/DOX not only served as a drug delivery system, but also as a powerful PTT agent for thermal ablation of tumor and a strong X-ray contrast agent for tumor diagnosis. In the in vitro and in vivo studies, MoS2-PEG/DOX exhibited excellent tumor-targeting efficacy, outstanding synergistic anti-cancer effect of photothermal and chemotherapy and X-ray imaging property, demonstrating that MoS2-PEG/DOX had a great potential for simultaneous diagnosis and photothermal-chemotherapy in cancer treatment.

【全文链接】https://doi.org/10.1016/j.ajps.2016.12.001