1. A smart responsive dual aptamers-targeted bubble-generating nanosystem for cancer triplex therapy and ultrasound imaging.

【作者】Feifei Zhao, Jie Zhou, Xiangjie Su, Yuhui Wang, Xiaosa Yan, Shaona Jia, Bin Du*【期刊名】Small

【影响因子】 2017年: 8.315

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2017,13(20):1-13

【关键词】dual aptamers;chemo-hyperthermia-bio therapy;ultrasound imaging; photothermal responsive

【摘要】The absence of targeted, single treatment methods have  produced low therapeutic value in treating cancers. To increase the accumulation of drugs in tumors and improve the treatment effectiveness, a NIR 808 nm photothermal responsive dual aptamers-targeted docetaxel (DTX)-containing nanoparticles is proposed. In this system, DTX and NH₄HCO₃ are loaded in thermosensitive liposomes. The surface of liposomes is coated with gold nanoshells and connected with sulfydryl (SH-) modified AS1411 and S2.2 aptamers. The nanosystem has good biocompatibility and uniform size (diameter about 200 nm). The drug could be rapidly released, reaching a maximum amount (84%) at 4h under 808nm laser irradiation. The experiments conducted in vitro and in vivo­ demonstrated the nanosystem could synergistically inhibit tumor growth by combination of chemotherapy, photothermal therapy, and biological therapy. Dual ligand functionalization significantly increased cellular uptake on MCF-7 cells and achieved ultrasound imaging (USI) at tumor site.  The results indicate that this drug delivery system is a promising theranostic agent involving light-thermal response at tumor sites, dual ligand targeted triplex therapy and US imaging.

【全文链接】www.small-journal.com