Pharmacokinetics of hydroxycamptothecin nanosuspensions in rats
【作者】Wang, Lei; Hua, Haiying; Liu, Weijing; Zhao, Yongxing; Zhang, Zhenzhong
【期刊名】Pharmazie.
【影响因子】 2011年: 1.006
【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China
【年，卷(期)：页码】2011, 66, 547-548.
【关键词】 BIOLOGICAL-ACTIVITY; CAMPTOTHECIN; DELIVERY
【摘要】The purpose of the present study was to investigate the pharmacokinetics of hydroxycamptothecin nanosuspensions after intravenous administration in rats. Hydroxycamptothecin injection was studied parallelly. The results showed that AUC(0 --> infinity), MRT, t1/2(alpha) and t1/2(beta) of hydroxycamptothecin nanosuspensions was significantly higher, while their total body clearance was lower than those of hydroxycamptothecin injections. The results indicate that hydroxycamptothecin nanosuspensions significantly increase hydroxycamptothecin blood concentrations and retention within the systemic circulation.
【全文链接】
http://chinesesites.library.ingentaconnect.com/content/govi/pharmaz/2011/00000066/00000007/art00014?crawler=true
