Synergistic enhancement of cancer therapy using a combination of docetaxel and photothermal ablation induced by single-walled carbon nanotubes.

【作者】Wang, Lei; Zhang, Mingyue; Zhang, Nan; Shi, Jinjin; Zhang, Hongling; Li, Min; Lu, Chao; Zhang, Zhenzhong

【期刊名】 INTERNATIONAL JOURNAL OF NANOMEDICINE

【影响因子】 2011年: 3.13

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2011, 6 : 2641—2652

【关键词】 single-walled carbon nanotubes, docetaxel, NGR peptide, tumor-targeting, near-infrared radiation

【摘要】Single-walled carbon nanotubes (SWNT) are poorly soluble in water, so their applications are limited. Therefore, aqueous solutions of SWNT, designed by noncovalent functionalization and without toxicity, are required for biomedical applications.

METHODS:

In this study, we conjugated docetaxel with SWNT via π-π accumulation and used a surfactant to functionalize SWNT noncovalently. The SWNT were then conjugated with docetaxel (DTX-SWNT) and linked with NGR (Asn-Gly-Arg) peptide, which targets tumor angiogenesis, to obtain a water-soluble and tumor-targeting SWNT-NGR-DTX drug delivery system.

RESULTS:

SWNT-NGR-DTX showed higher efficacy than docetaxel in suppressing tumor growth in a cultured PC3 cell line in vitro and in a murine S180 cancer model. Tumor volumes in the S180 mouse model decreased considerably under near-infrared radiation compared with the control group.

CONCLUSION:

The SWNT-NGR-DTX drug delivery system may be promising for high treatment efficacy with minimal side effects in future cancer therapy.

【全文链接】

https://www.dovepress.com/synergistic-enhancement-of-cancer-therapy-using-a-combination-of-docet-peer-reviewed-article-IJN