A novel chemiluminescence assay of mitoxantrone based on diperiodatocuprate(III) oxidation.

【作者】Hanchun Yao, Min Zhang, Wenyuan Zeng, Xiaoying Zeng, Zhenzhong Zhang

【期刊名】Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

【影响因子】 2014年: 2.353

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2014, 117: 645-650

【关键词】Chemiluminescence; Diperiodatocuprate; Mitoxantrone; Biological fluids

【摘要】A novel and strong chemiluminescence (CL) of luminol with diperiodatocuprate (K5[Cu(HIO6)2]) was observed in alkaline medium. After the addition of mitoxantrone (MTX) into this system, the CL intensity could be greatly inhibited by MTX. Based on the phenomenon, a sensitive CL method was established for analysis of MTX combining with flow injection technology. Under optimum experimental conditions, the CL intensity was linearly related to the logarithm concentration of MTX from 5.0  

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10

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9–1.0

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10

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7 g/ml with the detection limit of 1.1

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10

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9 g/ml (S/N = 3). The relative standard deviation was 1.2% for 5.0

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10

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8 g/ml of MTX. The proposed method was successfully applied for determination of MTX in pharmaceutical preparations and biological fluids. The possible CL reaction mechanism was also discussed briefly.

【全文链接】

http://dx.doi.org/10.1016/j.saa.2013.07.061