The antibacterial activit of covalent-functionalized carbon nanotubes against Escherichia coli.

【作者】 Li, A.; Wang, L.; Li, M.; Xu, Z.; Li P.; Zhang, Z.Z.

【期刊名】 Digest Journal of Nanomaterials and Biostructures

【影响因子】 2014年: 1.123

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2014, 9(2): 599-607

【关键词】 SWCNTs, FTIR, TGA , Zeta potential

【摘要】Single-walled carbon nanootubes (SWCNTs) were conjugated with hydroxyl, carboxyl and amino groups. Fourier transform infrared measurements validated the presence of a covalent linkage between SWCNTs and chemical groups. The antibacterial activity of functionalized SWCNTs was evaluated by standard plate count method, and the

transformation in micromorphology of the strains, Escherichia coli, induced by covalent-functionalized SWCNTs was achieved using scanning electron microscope. The

results indicated that pristine SWCNTs with high metal impurity content showed more active in antimicrobial activity than SWCNTs purified by diluted nitric acid. After the SWCNTs were functionalized by hydroxyl groups, the antibacterial activity was increased

compared to pristine and purified carbon nanotubes. The sequence of antibacterial activity

was SWCNTs-OH > raw SWCNTs > purified SWCNTs > SWCNTs-COOH > SWCNTs-NH2 , which was in accordance with the order of absolute value of zeta potential. It is the first time to report that antibacterial activity of SWCNTs is zeta potential

dependent. The antimicrobial activity was attributed to both functional groups and metal

impurity. The transformation of bacterial cells was studied using electron scanning microscopes. After interaction with SWCNTs, the cellular morphology of E. coli was flat,

and the strain died.

【全文链接】