Magnetic Multi-Walled Carbon Nanotubes for Tumor Theranostics.

【作者】Wang, Lei; Shi, Jinjin; Hao, Yongwei; Zhang, Panpan; Zhao, Yalin; Meng, Dehui; Li, Dong; Chang, Junbiao; Zhang, Zhenzhong

【期刊名】JOURNAL OF BIOMEDICAL NANOTECHNOLOGY

【影响因子】 2015年: 3.929

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2015, 11( 9) : 1653-1661

【关键词】 Multi-Walled Carbon Nanotubes; RNAi; Photothermal Therapy; MRI; Magnetic Tumor Targeting; Theranostics

【摘要】Current diagnostic techniques do not reliably detect cancer at early stages, and traditional chemotherapy lacks specificity and causes systemic toxicity. To address these issues, multifunctional nanomaterials are becoming more widely studied as a means of cancer detection, therapy, and monitoring. Here, iron oxide (Fe3O4) nanoparticles were conjugated onto the surface of multi-walled carbon nanotubes (MWNTs), which were then modified with polyethylenimine (PEI) and polyethylene glycol (PEG) to improve their solubility and biocompatibility. Finally, human telomerase reverse transcriptase (hTERT) siRNA was loaded on the MWNT surface by electrostatic interaction to obtain a multifunctional delivery system (MWNT-Fe3O4-PEI-PEG/siRNA). This delivery system efficiently delivered siRNA, allowed targeting of certain sites by magnetic fields, facilitated photothermal heating by near infrared irradiation, and enabled magnetic resonance imaging, thereby indicating great potential for cancer theranostic applications.

【全文链接】

http://chinesesites.library.ingentaconnect.com/content/asp/jbn/2015/00000011/00000009/art00012