Multimodal imaging-guided, dual-targeted photothermal therapy for cancer.

【作者】Bin Du，Xiaohui Cao，Feifei Zhao，Xiangjie Su，Yuhui Wang，Xiaosa Yan，Shaona Jia，Jie Zhou*，Hanchun Yao*.

【期刊名】Journal of Materials Chemistry B

【影响因子】 2017年: 4.872

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2016, 4: 2038-2050

【关键词】chemo-hyperthermia-bio therapy;ultrasound imaging; photothermal responsive

【摘要】The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during cancer therapy. Herein, dual-targeted photothermal therapy was achieved by the integration of upconversion nanoparticles, Fe 3 O 4 nanoparticles (IONPs), Prussian blue nanoparticles (PBNPs) and hyaluronic acid (HA). PBNPs converted near-infrared (NIR) light into heat and HA/Fe 3 O 4 NPs served as dual-targeting moieties. The as-obtained nanocomposites could also be applied as a multimodal probe for upconversion luminescence (UCL) imaging, enhanced T 2 -weighted magnetic resonance (MR) imaging and photoacoustic tomography (PAT) imaging. This multifunctional nanoparticle (MFNP) system prepared by a layer-by-layer (LBL) assembly method exhibited excellent dispersivity and low toxicity in vitro and in vivo. Furthermore, the research provided effective results for dual-targeted photothermal ablation of cancer with B4 fold higher tumor accumulation than that in the absence of HA/magnetic field. The photothermal therapeutic efficacy has been greatly improved in the S180 tumor model. We present a strategy for multimodal imaging-guided, dual-targeted physical cancer therapy and highlight the promise of using multifunctional nanostructures for cancer theranostics.

【全文链接】http://pubs.rsc.org/J. Mater. Chem. B, 2016, 4, 2038