Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery

【作者】Lin Hou, Yuyang Shi, Guixiang Jiang, Wei Liu, Huili Han,Qianhua Feng, Junxiao Ren, Yujie Yuan, Yongchao Wang,Jinjin Shi and Zhenzhong Zhang

【期刊名】Nanotechnology

【影响因子】 2015年: 3.573

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2016, 27: 315105

【关键词】graphene oxide, curcumin, pH-sensitive, composite hydrogels, colon-specific

delivery

【摘要】A safe and efficient nanocomposite hydrogel for colon cancer drug delivery was synthesized

using pH-sensitive and biocompatible graphene oxide (GO) containing azoaromatic crosslinks as

well as poly (vinyl alcohol) (PVA) (GO–N=N–GO/PVA composite hydrogels). Curcumin

(CUR), an anti-cancer drug, was encapsulated successfully into the hydrogel through a freezing

and thawing process. Fourier transform infrared spectroscopy, scanning electron microscopy and

Raman spectroscopy were performed to confirm the formation and morphological properties of

the nanocomposite hydrogel. The hydrogels exhibited good swelling properties in a pH-sensitive

manner. Drug release studies under conditions mimicking stomach to colon transit have shown

that the drug was protected from being released completely into the physiological environment

of the stomach and small intestine. In vivo imaging analysis, pharmacokinetics and a distribution

of the gastrointestinal tract experiment were systematically studied and evaluated as colonspecific

drug delivery systems. All the results demonstrated that GO–N=N–GO/PVA composite

hydrogels could protect CUR well while passing through the stomach and small intestine to the

proximal colon, and enhance the colon-targeting ability and residence time in the colon site.

Therefore, CUR loaded GO–N=N–GO/PVA composite hydrogels might potentially provide a

theoretical basis for the treatment of colon cancer with high efficiency and low toxicity.

【全文链接】http://iopscience.iop.org/article/10.1088/0957-4484/27/31/315105/pdf