An intelligent NIR-responsive chelate copperbasedanticancer nanoplatform for synergistictumor targeted chemo-phototherapy
【作者】 Qianhua Feng, Wanxia Zhang, Yuzhen Li, Xuemei Yang, Yongwei Hao, Hongling Zhang, Wei Li, Lin Hou,Zhenzhong Zhang
【期刊名】Nanoscale
【影响因子】 2017年:7.233
【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, China
【年，卷(期)：页码】2017, 9: 15685
【关键词】 hollow mesoporous copper sulfide,bleomycin, L-menthol, NIR responsive release,Cu-dependent chemo-phototherapy
【摘要】The chelate copper-based anticancer drug bleomycin (BLM) is usually believed to bind metal ionsespecially Cu(II) to generate the “activated BLM” for DNA cleavage.Herein, BLM and L-menthol (LM) coloadedhollow mesoporous Cu2-xS nanoparticles (HMCu2-xS NPs) with surface folic acid (FA) modificationwere formulated to construct an intelligent NIR-responsive nanoplatform for synergistic tumor targetedchemo-phototherapy. With the tumor targeting ability of the folate receptor (FR)-positive, FA-HMCu2-xS/BLM/LM could pinpoint tumor cells efficiently. Under NIR irradiation, the versatile HMCu2-xS would bebound to exploit the merits of phototherapy (including PTT and PDT-like effects) for cancer treatment.Meanwhile, benefiting from the controllable “solid–liquid” (S–L) phase transition feature of LM as a gatekeeper,FA-HMCu2-xS/BLM/LM offered a platform for simultaneous NIR-mediated temperatureresponsiveBLM and copper ion release, which further initiated the generation of the “activated BLM”. As amatter of course, the remarkable synergistic combination of Cu-dependent chemo-phototherapy in vitroand in vivo by such a smart all-in-one drug delivery nanoplatform developed here provided informationfor advancing nanotherapy in biomedical fields.
【全文链接】
https://pubs_rsc.gg363.site/en/content/articlehtml/2017/nr/c7nr05003h
