A Photo-Stable Indocyanine Green and Rapamycin Co-Delivery System Based on Poly(Glutamic Acid)-Modified Manganese Phosphate for Synergetic Tumor Therapy.

【作者】Hao, Yongwei ; Zheng, Cuixia ; Qiang, Hong ;Chen, Hongli; Wang, Fan ; Zhang, Jinjie ; Zhang, Hongling ; Wang, Lei ;Zhang, Zhenzhong ; Zhang, Yun

【期刊名】CHEMNANOMAT

【影响因子】 2018年:3.431

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2019,5(12):1477-1487 

【关键词】

amorphousporous manganese phosphate; phototherapy; autophagy; combination therapy

【摘要】Some manganese-based nanomaterials quench the fluorescence of photosensitizers, which strongly quenches fluorescence emission and suppresses reactive oxygen species (ROS) production due to the photo-induced charge transfer from the excited photosensitizer to nanomaterials. In this study, to overcome these disadvantages, amorphous porous manganese phosphate (MnP) nanoparticles are used for loading indocyanine green (ICG), and a broader ICG absorbance width instead of weakened fluorescence profile is observed, resulting in higher stability and phototherapy efficiency under 808 nm irradiation. Moreover, autophagy inhibition obviously weakens the ICG-mediated phototherapy to breast cancer cells. On this foundation, an autophagy promoter rapamycin (RAPA) and ICG are co-loaded into the MnP nanoparticles, and further decorated with biocompatible poly(glutamic acid). As expected, this stable nanoplatform released 80.0 +/- 4.1% agents at low pH compared to that 32.0 +/- 4.8% at normal pH, indicating a clear pH-responsive release profile. Uniting phototherapy with autophagy promoter by this system is found to achieve synergistic outcomes as evidenced by the smaller relative tumorvolume of 1.8 +/- 0.4. Overall, this work provides the first photo-stable manganese-based nanomaterial without fluorescence quenching profile for achieving multiple desirable therapeutic performances.

【全文链接】 https://doi.org/10.1002/cnma.201900572