A Magnetic Drug Delivery System with “OFF–ON” Statevia Specific Molecular Recognition and ConformationalChanges for Precise Tumor Therapy

【作者】Junjie Liu, Wei Liu, Kaixiang Zhang, Jinjin Shi, and Zhenzhong Zhang

【期刊名】Advanced Healthcare Materials

【影响因子】 2019年:6.357

【作者单位】School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2019, 1901316

【关键词】“ON–OFF” drug release, activated tumor therapy, DNA hairpinstructure, magnetic-targeting, MRI

【摘要】To enhance the tumor-targeting and tumor cell-specific drug-release capacityof nano drug delivery systems, a magnetic resonance imaging-traceable,magnetic-targeted nanoplatform is developed, and the nanoplatform is prepared by capping mesoporous silica (MSN)-coated iron oxide nanoparticles(IONPs) with programmable DNA hairpin sensor “gates.” In normal cells(HL-7702, human liver cells), the nanoplatform is able to entrap the loadeddrugs, showing an “OFF” state; the nanoplatform is activated by endogenousmiRNA-21 overexpressed in tumor cells (HepG2, human liver tumor cells),which serve as an exclusive key to unlock the nanoplatform through hybridization with programmable DNA hairpin, leading to a rapid drug release, showingan “ON” state. The nanoplatform exhibits high antitumor efficacy and low toxicity in in vitro and in vivo studies owing to its magnetic targeting and tumorcell-activated properties, paving the way for targeted and personalized tumortreatment and showing potential for clinical applications.tumor.

【全文链接】https://doi.org/10.1002/adhm.201901316