Aptamer/Photosensitizer Hybridized Mesoporous MnO2 Based TumorCell Activated ROS Regulator for Precise Photodynamic Therapy ofBreast Cancer

【作者】Wei Liu, Kaixiang Zhang, Luyang Zhuang, Junjie Liu, Wu Zeng,Jinjin Shi, Zhenzhong Zhang

【期刊名】Colloids and Surfaces B: Biointerfaces

【影响因子】 2019年:3.973

【作者单位】School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2019, 184: 110536

【关键词】Activated photodynamic therapy, Molecular recognition, ROS generation regulator, Aptamer

【摘要】Herein, we report a turn-on strategy for selectively killing the tumor cell via combining the singlet-oxygen quenching MnO2 and tumor cell-targeting aptamer. The photosensitizers were in the quenching state when loaded in the mesoporous MnO2 (mMnO2) nanoparticles and sealed by the aptamer on the particle surface. The aptamer can selectively recognize the specific membrane protein on the tumor cell and release the photosensitizers, activating the photosensitizer and killing the tumor cells. The specific binding-induced “off-on” switching of singlet oxygen generation reduced the damage to the nearby healthy cells to a large extent. The high loading ability for photosensitizer and the GSH consumption property of mMnO2 endow the system with high local concentration of singlet-oxygen for killing the target tumor cell. The high selectivity and efficiency of the constructed singlet oxygen regulating system will pave a new way for utilizing PDT in cancer precise treatment.

【全文链接】https://doi.org/10.1016/j.colsurfb.2019.110536