郑州大学药学院特聘教授，药剂学学科骨干，积大制药首席科学官。从中国药科大学获得博士学位，曾在美国加州大学洛杉矶分校先后从事博士后研究工作和任职助理教授，曾任美国Armagen Technologies Inc. 公司药理部主任，以及诺华上海研究中心肿瘤药理及转化医学研究室主任。多年来，一直从事新型药物转运系统及其在肿瘤治疗中的应用方面的研究工作，已有70多篇SCI论文发表在各种著名国际刊物上，如Advanced Materials, Advanced Functional Materials, PNAS, Molecular Therapy, Human Gene Therapy, The Journal of Gene Therapy，Journal of Controlled Release, Biomaterials，Pharmaceutical Research，Nanoscale, Journal of materials chemistry B等。曾主持完成三项美国NIH课题，已经主持结题四项中国国家自然科学基金课题，主持在研三项中国国家自然科学基金课题。获得中国发明专利三项。
联系方式：邮箱zhangyun@zzu.edu.cn、电话18601196725
工作与教育经历：
2007.01-至今，郑州大学，药学院药剂学系，特聘教授
2015.09-至今，昆明积大制药股份有限公司，副总经理（分管研发）及首席科学官
2008.10-2015.08，诺华制药上海研究中心，肿瘤药理及转化医学研究室主任
2003.08-2008.09，美国Armagen Technologies, Inc.公司，科学家及药理部主任
1999.10-2003.07，美国加州大学洛杉矶分校，医学院，博士后及助理教授
1996.09-1999.06，中国药科大学，药学院，博士
1993.07-1996.08，重庆医药工业研究院，药理研究室，助理工程师及工程师
1990.09-1993.06，西南农业大学，农学系，硕士
1986.09-1990.07，四川师范学院，生物系，学士
社会兼职：
荣誉称号及奖励：
专著与教材：
主持或参加研究项目（按照重要性及时间倒序排序）：
1. 国家自然科学基金面上项目，8217052905，具有逆转小胶质细胞炎症特性的工程化纳米活性系统用于缺血性脑卒中治疗研究，2022.01 - 2025.12，54万元，已批准，主持
2. 国家自然科学基金面上项目，81972907，肿瘤细胞双离子稳态“杠杆调控”纳米活性载体用于增强艾拉光动力治疗研究，2020.01-2023.12，51万元，在研，主持
3. 国家自然科学基金面上项目，81773276，治疗监测一体化的pH敏感-酶控型口服结肠靶向释药系统研究，2018.01 - 2021.12，55万元，在研，主持
4. 国家自然科学基金面上项目，81572991，基于二氧化锰纳米层构建的多功能肿瘤靶向诊断治疗系统研究，2016.01 - 2019.12，57万元, 已结题，主持
5. 国家自然科学基金面上项目，81272527，脑肿瘤靶向治疗的新策略研究，2013.01 -2016.12，70万元，已结题，主持
6. 国家自然科学基金面上项目，30973482，siRNA干扰联合热疗的碳纳米管肝肿瘤靶向性和治疗研究，2010.01 - 2012.12，31万元，已结题，主持
7. 国家自然科学基金面上项目，30772543，新型免疫脂质体介导双基因对实验性人肝癌的特异靶向性治疗研究2008.01 - 2010.12，29万元，已结题，主持
国家发明专利：
1. 任雪玲，张振中，柴丽娜，宋雨，张云，一种包含自剪切位点的组织特异性双基因沉默RNAi表达载体，授权，ZL201210033935.0.
2. 王蕾，郝永伟，张云，赵亚林，孟德辉，李懂，史进进，张振中，一种基于聚乳酸-羟基乙酸共聚物的靶向共载药物传递系统纳米粒的制备方法及应用，授权，ZL201310615647.0。
3. 王蕾，宋庆龄，张云，张振中，高慧，王珂，郑翠霞，赵洪娟，冯倩华，张红岭，一种基于益生菌芽孢衣壳纳米材料与益生菌组合物的制备方法及应用，授权，ZL 202011426215.1
学术论文：
1. Q. Song, H. Zhao, C. Zheng, K. Wang, H. Gao, Q. Feng, H. Zhang, Z. Zhang*, Y. Zhang* and L. Wang*, A bioinspired versatile spore coat nanomaterial for oral probiotics delivery, Advanced Functional Materials, 2021, doi:10.1002/adfm.202104994（一区）
2. Qingling Song, Cuixia Zheng, Jiajia Jia, Hongjuan Zhao, Qianhua Feng, Hongling Zhang, Lei Wang*, Zhenzhong Zhang*, Yun Zhang*. A Probiotic Spore-Based Oral Autonomous Nanoparticles Generator for Cancer Therapy. Advanced Materials. 2019, 201903793. (一区)
3. Qingling Song, JiajiaJia, XiuxiuNiu, CuixiaZheng, Hongjuan Zhao, Lingling Sun, Hongling Zhang, Lei Wang*, Zhenzhong Zhang*, Yun Zhang*. An oral drug delivery system with programmed drug release and imaging properties for orthotopic colon cancer therapy. Nanoscale. 2019,11, 15958-15970.（一区）
4. Lei Wang, Yujie Hua, Yongwei Hao, Li Li, Cuixia Zheng, Hongjuan Zhao, Mengya Niu, Yanyan Yin, Zhenzhong Zhang*, Yun Zhang*. Journal of Controlled Release. 2020;318: 197–209.（一区）
5. L. Wang, X. Niu, Q. Song, J. Jia, Y. Hao, C. Zheng, K. Ding, H. Xiao, X. Liu, Z. Zhang, Y. Zhang*, A two-step precise targeting nanoplatform for tumor therapy via the alkyl radicals activated by the microenvironment of organelles, J Control Release 318 (2020) 197-209.（一区）
6. Y. Hao, C. Zheng, H. Qiang, H. Chen, F. Wang, J. Zhang, H. Zhang, L. Wang, Z. Zhang, Y. Zhang, A Photo‐Stable Indocyanine Green and Rapamycin Co‐Delivery System Based on Poly(Glutamic Acid)‐Modified Manganese Phosphate for Synergetic Tumor Therapy, ChemNanoMat 5(12) (2019) 1477-1487.（二区）
7. Yongwei Hao, Cuixia Zheng, Lei Wang, Jinjie Zhang, Xiuxiu Niu, Qingling Song, Qianhua Feng, Hongjuan Zhao, Li Li, Hongling Zhang, Zhenzhong Zhang and Yun Zhang*. Tumor acidity-activatable Manganese Phosphate Nanoplatform for Amplification of Photodynamic Cancer Therapy and Magnetic Resonance Imaging. Acta Biomaterialia, 2017, 62: 293-305.（一区）
8. Yongwei Hao, Cuixia Zheng, Lei Wang, Yujie Hu, Haochen Guo, Qingling Song, Hongling Zhang, Zhenzhong Zhang and Yun Zhang*. Covalent self-assembled nanoparticles with pH-dependent enhanced tumor retention and drug release for improving tumor therapeutic efficiency. Journal of Materials Chemistry B, 2017, 5: 2133-2144.（二区）
9. Lei Wang, Dong Li, Yongwei Hao, Mengya Niu, Yujie Hu, Hongjuan Zhao, Junbiao Chang, Zhenzhong Zhang and Yun Zhang*. A gold nanorod based PLGA@MnO2 core-shell structured multi-functional nanoplatform for cancer theranostic applications. International Journal of Nanomedicine, 2017, 12: 3059-3075.（二区）
10. Lei Wang, Dehui Meng, Yongwei Hao, Yujie Hu, Mengya Niu, Cuixia Zheng, Yanyan Yin, Dong Li, Panpan Zhang, Junbiao Chang, Zhenzhong Zhang and Yun Zhang*. A gold nanostar based multi-functional tumor-targeting nanoplatform for tumor theranostic applications. Journal of Material Chemistry B, 2016, 4: 5895-5906.（二区）
11. Yongwei Hao, Lei Wang, Bingxiang Zhang, Dong Li, Dehui Meng, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang and Yun Zhang*. Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application. International Journal of Nanomedicine, 2016, 11: 1759-1778. （二区）
12. Yongwei Hao, Lei Wang, Bingxiang Zhang, Hongjuan Zhao, MengYa Niu, Yujie Hu, Cuixia Zheng, Hongling Zhang, Junbiao Chang , Zhenzhong Zhang and Yun Zhang*. Multifunctional nanosheets based on folic acid modified manganese oxide for tumor targeting theranostic application. Nanotechnology, 2016, 27: 025101.（二区）
13. Haixia Li, Yongwei Hao, Ning Wang, Shasha Jia, Yali Wang, Lijia Yang, Yun Zhang* and Zhenzhong Zhang. DOTAP functionalizing single-walled carbon nanotubes as non-viral vectors for efficient intracellular siRNA delivery. Drug Delivery, 2016, 23: 840-848.（二区）
14. Yongwei Hao, Bingxiang Zhang, Cuixia Zheng, Rui Ji, Xiangyi Ren, Fangfang Guo, Shili Sun, Jinjin Shi, Hongling Zhang, Zhenzhong Zhang, Lei Wang and Yun Zhang*. The tumor-targeting core-shell structured DTX-loaded PLGA@Au nanoparticles for chemo-photothermal therapy and X-ray imaging. Journal of Controlled Release, 2015, 220: 545-555.（一区）
15. Lei Wang, Dehui Meng, Yongwei Hao, Yalin Zhao, Dong Li, Bingxiang Zhang, Yun Zhang* and Zhenzhong Zhang. Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications. Journal of Biomaterials Applications, 2015, 30: 547-557. （三区）
