博士，郑州大学教授，河南省特聘教授，河南省优秀青年科学基金获得者，中原青年拔尖人才，河南省优秀青年科技专家，河南省教育厅学术技术带头人，河南省高等学校青年骨干教师，河南省教学标兵，入选2019年度河南省青年人才托举工程项目计划，第十四届河南省青年科技奖获得者。ACS Nano, Nano today, ACS Applied Materials & Interfaces等国际权威杂志特邀审稿人。本硕博连读于中国药科大学，访学于University of North Carolina。多年来一直从事智能纳米药物转运系统研究，构建了一系列能够实现疾病精确定位和个体化治疗的新型高分子材料和新剂型，对于减少药物不良反应、提高疗效、保障用药安全具有重要意义，并在化疗、热疗、免疫治疗等方面取得一定成果。主持本领域课题13项（含国家自然科学基金项目4项），在Advanced Materials、ACS Nano、Angewandte Chemie International Edition、Nano Today、Journal of Controlled Release、Biomaterials等国际权威杂志发表高水平SCI论文50余篇；授权专利25项；荣获河南省科技进步一等奖、河南省第十四届青年科技奖、河南省教育厅科技成果一等奖、河南省教育厅优秀科技论文一等奖等。
联系方式：邮箱：houlin_pharm@163.com
工作与教育经历：
2011.6-至今郑州大学，药学院药物制剂系，教授
2017.1-2018.1 University of North Carolina at Chapel Hill，访问学者
2006.9-2011.6中国药科大学，药剂学，博士（硕博连读）
2002.9-2006.6中国药科大学，基础药学理科基地，学士
社会兼职：
• 河南省药学会药物制剂专委会委员兼秘书
荣誉称号及奖励：
•2022年河南省特聘教授
•2021年中原青年拔尖人才
•2021年河南省优秀青年科学基金
•2021年河南省优秀科技论文奖一等奖
•2020年河南省教育厅学术技术带头人
•2019年河南省第十四届青年科技奖，河南省优秀青年科技专家
•2018年河南省科学技术进步奖一等奖
•2018年河南省优秀科技论文奖一等奖
•2017年河南省科学技术成果奖一等奖
•2016年河南省科学技术成果
•2016年河南省药学会优秀药学工作者
•2014年河南省教学标兵
•2013年河南省中青年教师讲课比赛特等奖
专著与教材：
•侯琳（副主编），《分子生物药剂学》，郑州大学出版社，2019年
•侯琳（参编），《药学英语》（第五版），人民卫生出版社，2016年
•侯琳（参编），《药学实验与指导》（第二版），郑州大学出版社，2015年
主持或参加研究项目：
1. 国家自然科学基金面上项目，82172719，微环境触发重组调控型工程菌增强肿瘤免疫治疗的研究，2022/01-2025/12，在研，主持。
2. 国家自然科学基金面上项目，81972893，肿瘤天然“区位”调控的纳米形变系统增效食管癌免疫化疗研究，2020/01-2023/12，在研，主持。
3. 国家自然科学基金联合基金项目，U1704172，“血糖感应-触控开关型”胰岛素递送系统用于安全平稳控糖研究，2018/01-2020/12，结题，主持。
4. 国家自然科学基金青年基金项目，81202485，基于“导航式”氧化石墨烯纳米层构建的多功能光热联合化疗系统研究，2012/01-2015/12，结题，主持。
5. 中国博士后科学基金特别资助，2019T120643，TME调控”纳米免疫化疗系统抗食管癌的研究，2019/01-2020/12，在研，主持。
6. 中国博士后科学基金面上一等资助，2018M640686，双靶点”-“高渗透”纳米递药系统抗食管癌的研究，2019/01-2020/12，在研，主持。
7. 河南省优秀青年科学基金，212300410071，智能纳米递送系统调控微环境用于增强抗肿瘤免疫治疗的研究，2021/01-2023/12，25万，在研，主持。
8. 河南省高等学校重点科研项目计划基础研究专项，19zx005，“智能响应型”胰岛素纳米制剂用于精细控糖研究，2019/01-2021/12，在研，主持。
9. 河南省青年人才托举工程项目，2019HYTP017，智能纳米递送系统用于胰岛素精细控糖研究，2019/01-2020/12，结题，主持。
10. 中国博士后科学基金特别资助，2013T60709，智能型氧化石墨烯构建的口服结肠靶向递药水凝胶研究，2013/01-2014/12，结题，主持。
11. 中国博士后科学基金面上二等资助，2012M521411，氧化石墨烯构建的多机制、靶向光热联合化疗系统研究，2012/01-2014/12，结题，主持。
12. 河南省科技攻关项目，162102310510，蜂巢巡航式硫化铜纳米粒介导的肿瘤诊疗一体化门控释药体系的研究，2016/01-2017/12，结题，主持。
13. 国家自然科学基金面上项目，81673021，一种智能型“自供氧”“可视化”肿瘤靶向治疗系统的研究，2017/01-2020/12，在研，参与。
14. 国家自然科学基金青年项目，81601597，“导航式”生物纳米囊共载药系统用于脑梗死精准三位一体治疗研究，2017/01-2019/12，结题，参与。
国家发明专利：
1. 侯琳；张振中；田春雨；闫莹珊；张红岭；陈丹丹；张乐文；黄千笑，脂质膜包裹负载DNA拓扑异构酶Ⅱ抑制剂的无定型介孔磷酸锰药物复合物制备方法，2021.7.6，中国，ZL 2019 1 0439544.0
2. 侯琳，张振中，张银玲，郝丽莎，郑亚珍，一种基于透明质酸的能够递送一氧化氮的胶束制备方法与应用，授权，ZL 2016 1 1237444.2
3. 侯琳，张振中，杨雪梅，冯倩华，李玉真，张红岭，一种癌细胞膜包裹的负载自噬抑制剂的中空介孔二氧化钛仿生药物复合物的制备方法及应用，授权，ZL 2017 1 1431735.X
4. 侯琳，张振中，郝丽莎，张银玲，郑亚珍，对FAP-α酶、还原环境双敏感的粒径收缩型的肿瘤渗透性纳米系统的制备方法及其应用，授权，ZL 2016 1 1238615.3
5. 侯琳，张振中，王用超，杨晓敏，张银玲，袁玉洁，张媛媛，一种负载吲哚菁绿的自组装多功能纳米靶向系统的制备方法及其应用，授权，ZL 2015 1 0581283.8
6. 侯琳，单晓宁，张振中，冯倩华，郝丽莎，袁玉洁，王用超，一种转铁蛋白修饰的中空介孔硫化铜/青蒿琥酯纳米粒的制备方法及其应用，授权，ZL 2015 1 0549228.0
7. 侯琳，杨晓敏，张振中，王用超，任俊晓，石宇洋，透明质酸修饰单壁碳纳米管制备诊断治疗的还原敏感性药物纳米剂的方法及应用哦，授权，ZL 2015 1 0432004.1
8. 侯琳，张振中，石宇洋，蒋桂香，毛艳艳，杨晓敏，一种基于碳材料的多糖类口服结肠靶向水凝胶的制备方法与应用，授权，ZL 2014 1 0521958.2
9. 侯琳，张振中，蒋桂香，冯倩华，张红岭，一种氧化石墨烯衍生物的制备方法与应用，授权，ZL 2013 1 0397861.3
10. 侯琳，张振中，王丽丽，王亚婷，张慧娟，张红岭，一种以透明质酸修饰的羧基化短单壁碳纳米管为载体的钆类造影剂及其制备方法和应用，授权，ZL 2013 1 0397793.0
11. 侯琳，张振中，胡志军，张红岭，透明质酸修饰的氧化石墨烯及其药物组合物的制备方法与应用，授权，ZL 2012 1 0561306.5
学术论文（近五年）：
1. Lin Hou*, Xuan Gong, Jing Yang, Huijuan Zhang, Weijing Yang*, Xiaoyuan Chen*. Hybrid-Membrane-Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor-Associated Macrophages Polarization and Hypoxia Relief. Advanced Materials, 2022, 2200389.
2. Weijing Yang*, Meng Zhang, Jinjie Zhang, Yanlong Liu, Jie Ning, Jing Yang, Zhenzhong Zhang, Lin Hou*, Xiaoyuan Chen*. In vivo activated T cell targeting with PD-1/PD-L1 blockade for sequential treatment mediated cancer immunotherapy. Nano Today, 2022, 44, 101492.
3. Huijuan Zhang, Yamin Pei, Linyu Gao, Qingqing He, Hongling Zhang, Ling Zhu⁎, Zhenzhong Zhang⁎, Lin Hou⁎. Shear force responsive and fixed-point separated system for targeted treatment of arterial thrombus. Nano Today, 2021, 38, 101186.
4. Lin Hou*, Dandan Chen, Ruiting Wang, Ruibing Wang, Huijuan Zhang, Zhenzhong Zhang,
Zhihong Nie*, Siyu Lu*. Transformable Honeycomb‐Like Nanoassemblies of Carbon Dots for Regulated Multisite Delivery and Enhanced Antitumor Chemoimmunotherapy. Angewandte Chemie International Edition, 2021, 60, 12, 6581-6592.
5. Lin Hou, Yanlong Liu, Wei Liu, Mervat Balash, Hongling Zhang, Yi Zhanga, Huijuan Zhang, Zhenzhong Zhang *. In situ triggering antitumor efficacy of alcoholabuse drug disulfiram through Cu-based metalorganic framework nanoparticles. Acta Pharmaceutica Sinica B, 2021, 11(7): 2016-2030.
6. Yifei Wang, Ruiting Wang, Sixuan Wu, Jingyi An, Yan Liang, Lin Hou*, Zhenzhong Zhang*. Self-responsive co-delivery system for remodeling tumor intracellular microenvironment to promote PTEN-mediated anti-tumor therapy[J]. Nanoscale, 2020,12:9392-9403.
7. Lin Hou*, Chunyu Tian, Yingshan Yan, Lewen Zhang, Huijuan Zhang*, and Zhenzhong Zhang*. Manganese-based nanoactivator optimizes cancer immunotherapy via enhancing innate immunity[J]. ACS Nano 2020,14:3927-3940.
8. Lin Hou*, Yingshan Yan, Chunyu Tian, Qianxiao Huang, Xiangjing Fu, Zhen Zhang, Hongling Zhang, Huijuan Zhang*, Zhenzhong Zhang*. Single-dose in situ storage for intensifying anticancer efficacy via combinatorial strategy[J]. J Control Release 2020,319:438-449.
9. Huijuan Zhang, Yamin Pei, Xiaoge Zhang, Ling Zhu,Lin Hou*, Junbiao Chang*, Zhenzhong Zhang*. Engineering of an intelligent cascade nanoreactor for sequential improvement of microenvironment and enhanced tumor phototherapy[J]. Applied Materials Today 2020,18:100494.
10. Huijuan Zhang, Hongyan Qu, Jianjiao Chen, Mengting Li, Huimin Du, Lin Hou*, Junbiao Chang*, Zhenzhong Zhang*. Construction and research on size and phase “fixed-point remodelling” intelligent drug delivery system[J]. Journal of Drug Targeting DOI: 10.1080/1061186X.2020.1807999.
11. Huijuan Zhang, Fang Cao, Ling Zhu*, Lin Hou*, and Zhenzhong Zhang*. An ultrasound-triggered ROS sustained supplier based on open source and reduce expenditure strategy for colon cancer therapy[J]. ChemNanoMat 2020,6:984-995.
12. Huijuan Zhang, Xiaoge Zhang, Yanping Ren, Fang Cao, Lin Hou*, Zhenzhong Zhang*. An in situ microenvironmental nano-regulator to inhibit the proliferation and metastasis of 4T1 tumor[J]. Theranostics 2019,9(12):3580-3594.
13. Lin Hou,Dandan Chen, Lisha Hao, Chunyu Tian, Yingshan Yan, Ling Zhu, Huijuan Zhang*, Yi Zhang*, Zhenzhong Zhang*. Transformable nanoparticles triggered by cancer-associated fibroblasts for improving drug permeability and efficacy in desmoplastic tumors[J]. Nanoscale 2019,11(42):20030-20044.
14. Lin Hou, Chunyu Tian, Dandan Chen, Yujie Yuan, Yingshan Yan, Qianxiao Huang, Huijuan Zhang*, Zhenzhong Zhang*. Investigation on vitamin e succinate based intelligent hyaluronic acid micelles for overcoming drug resistance and enhancing anticancer efficacy[J]. Eur J Pharm Sci 2019,140:105071.
15. Lin Hou, Yinling Zhang, Xuemei Yang, Chunyu Tian, Yingshan Yan, Hongling Zhang, Jinjin Shi, Huijuan Zhang*, Zhenzhong Zhang*. Intracellular NO-generator based on enzyme trigger for localized tumor-cytoplasm rapid drug release and synergetic cancer therapy[J]. ACS Appl. Mater. Interfaces 2019,11:255-268.
16. Huijuan Zhang, Yanping Ren, Fang Cao, Jianjiao Chen, Chengqun Chen, Junbiao Chang, Lin Hou∗, Zhenzhong Zhang∗. In situ autophagy disruption generator for cancer theranostics[J]. ACS Appl. Mater. Interfaces 2019,11:29641-29654.
17. Qianhua Feng, Xuemei Yang, Yutong Hao, Ning Wang, Xuebing Feng, Lin Hou∗, Zhenzhong Zhang∗. Cancer cell membrane-biomimetic nanoplatform for enhanced sonodynamic therapy on breast cancer via autophagy regulation strategy[J]. ACS Appl. Mater. Interfaces 2019,11:32729-32738.
18. Lin Hou, Qi Liu, Limei Shen, Yun Liu, Xueqiong Zhang, Fengqian Chen, Leaf Huang*. Nano-delivery of fraxinellone remodels tumor microenvironment and facilitates therapeutic vaccination in desmoplastic melanoma[J]. Theranostics 2018,8(14): 3781-3796.
19. Qianhua Feng, Yuzhen Li, Xuemei Yang, Wanxia Zhang, Yongwei Hao, Hongling Zhang, Lin Hou∗, Zhenzhong Zhang∗. Hypoxia-specific therapeutic agents delivery nanotheranostics: A sequential strategy for ultrasound mediated on-demand tritherapies and imaging of cancer[J]. J Control Release 2018,275:192-200.
20. Lin Hou*, Yazhen Zheng, Yongchao Wang, Yurong Hu, Jinjin Shi, Qi Liu, Huijuan Zhang, Zhenzhong Zhang*. Self-regulated carboxyphenylboronic acid-modified mesoporous silica nanoparticles with "Touch Switch" releasing property for insulin delivery[J]. ACS Appl. Mater. Interfaces 2018,10:21927-21938.
21. Qianhua Feng, Wanxia Zhang, Xuemei Yang, Yuzhen Li, Yongwei Hao, Hongling Zhang, Lin Hou*, and Zhenzhong Zhang*. pH/Ultrasound dual-responsive gas generator for ultrasound imaging-guided therapeutic inertial cavitation and sonodynamic therapy[J]. Adv Healthc Mater 2018,7:1700957.
22. Qianhua Feng, Wanxia Zhang, Yuzhen Li, Xuemei Yang, Yongwei Hao, Hongling Zhang, Wei Li, Lin Hou∗, Zhenzhong Zhang∗. An intelligent NIR-responsive chelate copper-based anticancer nanoplatform for synergistic tumor targeted chemo-phototherapy[J]. Nanoscale 2017,9:15685.
23. Lin Hou, Yujie Yuan, Junxiao Ren, Yinling Zhang, Yongchao Wang, Xiaoning Shan, Qi Liu, Zhenzhong Zhang*. In vitro and in vivo comparative study of the phototherapy anticancer activity of hyaluronic acid-modified single-walled carbon nanotubes, graphene oxide, and fullerene[J]. Journal of Nanoparticle Research 2017,19:286.
24. Qianhua Feng, Yuanyuan Zhang, Wanxia Zhang, Yongwei Hao, Yongchao Wang, Hongling Zhang, Lin Hou∗, Zhenzhong Zhang∗. Programmed near-infrared light-responsive drug delivery system for combined magnetic tumor-targeting magnetic resonance imaging and chemo-phototherapy[J]. Acta Biomater 2017,49:402-413.
25. Lin Hou, Xiaoning Shan, Lisha Hao, Qianhua Feng, Zhenzhong Zhang*. Copper sulfide nanoparticle-based localized drug delivery system as an effective cancer synergistic treatment and theranostic platform[J]. Acta Biomater 2017,54:307-320.
26. Xiali Zhu, Yingjie Zhang, Heqing Huang, Huijuan Zhang, Lin Hou*, Zhenzhong Zhang*. Folic acid-modified and functionalized CuS nanocrystal-based nanoparticles for combined tumor chemo- and photothermal therapy[J]. J Drug Target 2017,25(5): 425-435.
27. Jinjin Shi, Binghua Wang, Zhaoyang Chen, Wei Liu, Jingjing Pan, Lin Hou*, Zhenzhong Zhang*. A multi-functional tumor theranostic nanoplatform for MRI guided photothermal-chemotherapy[J]. Pharm Res 2016,33(6):1472-85.
28. Lin Hou, Yuyang Shi, Guixiang Jiang, Wei Liu, Huili Han, Qianhua Feng, Junxiao Ren, Yujie Yuan, Yongchao Wang, Jinjin Shi*, Zhenzhong Zhang*. Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery[J]. Nanotechnology 2016,27(31):315105.
29. Lin Hou, Qianhua Feng, Yating Wang, Xiaomin Yang, Junxiao Ren, Yuyang Shi, Xiaoning Shan, Yujie Yuan, Yongchao Wang, Zhenzhong Zhang*. Multifunctional hyaluronic acid modified graphene oxide loaded with mitoxantrone for overcoming drug resistance in cancer[J]. Nanotechnology 2016,27(1):015701.
30. Lin Hou, Xiaomin Yang, Junxiao Ren, Yongchao Wang, Huijuan Zhang, Qianhua Feng, Yuyang shi, Xiaoning Shan, Yujie Yuan, Zhenzhong Zhang*. A novel redox-sensitive system based on single-walled carbon nanotubes for chemo-photothermal therapy and magnetic resonance imaging[J]. Int J Nanomedicine 2016,11:607-24.
31. Huijuan Zhang, Qianqian Chen, Xiaoge Zhang, Xing Zhu, Jianjiao Chen, Hongling Zhang, Lin Hou∗, Zhenzhong Zhang∗. An intelligent and tumor-responsive Fe2+ donor and Fe2+-Dependent drugs cotransport system[J]. ACS Appl. Mater. Interfaces 2016,8:33484-33498.
32. Qianhua Feng, Yuanyuan Zhang, Wanxia Zhang, Xiaoning Shan, Yujie Yuan, Hongling Zhang, Lin Hou∗, Zhenzhong Zhang∗. Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography[J]. Acta Biomater 2016,38:129-42.
