李春瞳
博士，郑州大学初聘副教授。2025年博士毕业于清华大学化学系。主要研究方向为：1）泛素/类泛素蛋白工具的开发及生物学应用；2）基因编辑酶的定向进化及生物传感应用。相关研究成果以第一作者或通讯作者在J. Am. Chem. Soc., Angew. Chem. Int. Ed.等期刊发表研究论文5篇，累计发表SCI收录论文13篇,被引100余次。授权发明专利2项。
联系方式：lct0626@zzu.edu.cn
工作与教育经历：
2025.08-至今，郑州大学，药学院药物分析系，初聘副教授
2020.09-2025.06，清华大学，化学，博士
2016.09-2020.06，中国科学技术大学，化学，学士
社会兼职：
• 河南省生物物理学会 会员
荣誉称号及奖励：
• 无
专著与教材：
• 无
主持或参加研究项目：
1. 无
国家发明专利：
1. 李景虹，赵芳誉，李春瞳，原核表达高效获取Cullin1-Rbx1 E3连接酶复合物的方法，授权，ZL 2024 1 1290897.6
2. 刘磊，王天，王玫景，何伟，李春瞳，李景虹. 产生基于类泛素或泛素蛋白的生化工具的方法，授权，ZL 2021 1 1301856.9
学术论文：
1. Li, C.; Zhao, F.; Li, X.; Zuo, C.; Liu, Y.; Huang, Y. ;Shi, L.; Liu, Y.; Sun, S.; Yuan, L.; Ai, H.*; Liang, L.*; Li, J.* Design and Semi-synthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1 Mediated Substrate Polyubiquitination. Journal of the American Chemical Society. 2025, 147(27): 23878-23890. (SCI 一区 top)
2. Wang, B. #; Li, C. # *; Zhao, F.; Shi, L.; Li, X.; Liu, Y.; Sun, S.; Yuan. L.; Sun, M.; Zhang, Y.; Shi, J.*; Liang, L.* Examining the role of threonine phosphorylation on ubiquitin activity using chemical protein synthesis. JACS Au. 2025, 5(5): 2148-2158. (SCI 一区 top)
3. Zhao, F.#; Li, C. #*; Li, X.; Shi, L.;Zhang, Y.; Wang, H.; Sun, S.; Liang, L.* Expression and purification of functional recombinant CUL1•RBX1/2 from E. coli. Protein Expression and Purification. 2025, 233: 106750.
4. Han, D.#, Cui, Y.#, Deng, X.#, Li, C., Zhu, X., Wang, B., Chu, G., Wang, A., Tang, S., Zheng, J., Liang, L.*, Liu, L.* Mechanically triggered protein desulfurization. Journal of the American Chemical Society. 2025, 147(5), 4135–4146. (SCI 一区 top)
5. Tao, S. #; He, Wei. #; Li, C.; Liang, J.; Tong, Z.; Deng, Z.; Zhang, L.; Ai, H. *; Liang, L. *; Liu, L.* Synthesis of an E2-Ub-nucleosome conjugate to capture the E3 ligase PHF7-catalyzed H3K14 ubiquitination intermediate. Science China. Chemistry. 2025, 68: 5871-5880. (SCI 一区 top)
6. Sun, S., Li, C., Hou, H.*, Li, J*. Protein-metabolite Interactions Based on Chemical Targeting Methods. Chembiochem. 2025;26(8):e202400852.
7. Chu, G.# Liang, L.# Zhao, R.# Guo, Y., Li, C., Zuo, C., Ai, H., Hua, X., Li, Z., Li, Y., Liu, L.* Ferricyanide-Promoted Oxidative Activation and Ligation of Protein Thioacids in Neutral Aqueous Media. CCS Chemistry. 2024, 6, 2031–2043. (SCI 一区 top)
8. Li, C.; Wang, T.; Liang, L.; Chu, G.; Zhang, J.; He, W.*; Liu, L.*; Li, J.* Simultaneous Capture of ISG15 Conjugating and Deconjugating Enzymes Using a Semi-Synthetic ISG15-Dha Probe. Science China. Chemistry. 2023, 66(3): 837-844. (SCI 一区 top)
9. Liang, L.# Wang, Y.#, Hua, X.#, Yuan, R., Xia, Q., Wang, R., Li, C., Chu, G., Liu, L.*, Li, Y.* Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time-Resolved Monitoring of Substrate Ubiquitination in Live Cells. JACS Au. 2023;3(10):2873-2882. (SCI 一区 top)
10. Wang, T. #; Li, C. #; Wang, M. #; Zhang, J.; Zheng, Q.; Liang, L.; Chu, G.; Tian, X.; Deng, H.; He, W.*; Liu, L.*; Li, J.* Expedient Synthesis of Ubiquitin-like Protein ISG15 Tools through Chemo-Enzymatic Ligation Catalyzed by a Viral Protease Lbpro. Angewandte Chemie International Edition, 2022; 61(40): e202206205. (SCI 一区 top)
