A “protective umbrella” nanoplatform for loading ICG and multi-modal imaging-guided phototherapy

【作者】Jie Zhou, Lingchang Meng, Chong Sun, Weiran Ye, Chengqun Chen, Bin Du,

【期刊名】Nanomedicine: Nanotechnology, Biology, and Medicine

【影响因子】2018年: 5.570

【作者单位】School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2018, 14(2): 289-301

【关键词】NIR-induced; Photodynamic therapy; Photothermal therapy; Improving the stability; Indocyanine green

【摘要】In order to prevent the aggregation of ICG and enhance its stability, a novel nanoplatform (TiO₂:Yb,Ho,F-β-CD@ICG/HA) was designed for NIR-induced phototherapy along with multi-mode imaging(UCL/MRI/Flu). In this nanosysytem: TiO₂:Yb,Ho,F was used as upconversion materials and applied in vivo for the first time; β-CD acted as a “protective umbrella” to load separated ICG and avoid the low phototherapy efficiency because of its aggregation; HA was the capping agent of β-CD to prevent ICG unexpected leaking and a target to recognize CD44 receptor. The nanosystem exhibited excellent size (~200 nm) and photo- and thermal-stability, preferable reactive oxygen yield and temperature response (50.4 °C) under 808 nm laser. It could efficiently target and suppress tumor growth. The imaging ability (UCL/MRI) of TiO₂:Yb,Ho,F could facilitate diagnosis of the tumor, especially for deep tissues. Altogether, our work successfully improved the phototherapy efficacy through incorporating the ICG into the cavity of β-CD and applied TiO₂:Yb,Ho,F for upconversion imaging in vivo.

【全文链接】https://www.sciencedirect.com/science/article/pii/S1549963417301764