Construction and evaluation of tumor nucleus-targeting nanocomposite for cancer dual-mode imaging – Guiding photodynamic therapy/photothermal therapy

【作者】Jie Zhou; Qiaolei Wang; Shizhen Geng; Rui Lou; Qianwen Yin; Weiran Ye

【期刊名】Materials Science & Engineering C

【影响因子】2019年: 5.880

【作者单位】School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2019, 102：541–551

【关键词】WS₂nanoparticles; Au₂₅nanoclusters; Single excitation laser; Nucleus targeting; PTT/PDT

【摘要】To tackle the barrier of the insufficient intra-cellular delivery of reactive oxygen species (ROS) and heat, we designed a multifunctional nanoplatform to release ROS and heat directly in the cell nucleus for enhancing combined photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors. As a photothermal agent, WS₂nanoparticles were adsorbed photosensitive Au₂₅(Captopril)₁₈− (Au₂₅) nanoclusters via electrostatic interaction. And Dexamethasone (Dex), a glucocorticoid with nucleus targeting capability, played a key role in the intra-nuclear process of heat and ROS. PTT can increase intra-tumoral blood flow to promote Au₂₅produce more ROS for PDT. Under near infrared (NIR) laser irradiation at a single 808 nm, these nucleus targeting WS₂ nanoplatforms showed a significant decreased cell viability of 18.2 ± 1.7% and a high DNA damage degree of 59.6 ± 8.3%. Furthermore, the WS₂nanoplatform could be further used for X-ray computed tomography (CT) images. Taken together, our study provided a new prospect for effectively diagnostic and enhancing PTT/PDT efficacy.

【全文链接】https://www.sciencedirect.com/science/article/pii/S092849311833159X