A Bioinspired Versatile Spore Coat Nanomaterial for Oral Probiotics Delivery

【作者】Qingling Song, Hongjuan Zhao, Cuixia Zheng, Ke Wang, Hui Gao, Qianhua Feng, Hongling Zhang, Zhenzhong Zhang,* Yun Zhang,* and Lei Wang*

【期刊名】AdvancedFunctional Materials

【影响因子】2021年: 18.808

【作者单位】School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2021, 2104994

【关键词】bioinspired nanomaterial, competitive colonization, oral probiotics delivery, spore coat, universal strategy

【摘要】A fundamental challenge in probiotic therapy is effective delivery and rapid colonization of probiotics; however, the physiological structure of probiotic spores provides an interesting idea to address this problem. Herein, the spore coat is innovatively prepared into a type of versatile spore coat nanomaterial (CN) which is subsequently anchored to the surface of probiotics to form CN-coated probiotics. The CN retains the characteristics of high resistance and natural affinity of spore coats, which serve as the “armor” for the enhancement of the probiotics delivery. Moreover, CN is beneficial for the explosive proliferation and competitive colonization of probiotics. Notably, it is found that not only CN used solely has good anti-inflammatory effect, but also it can significantly improve the functions of probiotics such as microbiome regulation, gut barrier integrity and tumor prevention. This work provides a simple and universal strategy that may guide the development of nanomaterial and material-based microecological agents.

【全文链接】

https://onlinelibrary.wiley.com/doi/10.1002/adfm.202104994