Biological chemotaxis-guided self-thermophoretic nanoplatform augments colorectal cancer therapy through autonomous mucus penetration
【作者】Wang, Zhi-Hao; Chu, Mengyu; Yin, Na; Huang, Wanting; Liu, Wei; Zhang, Zhenzhong; Liu, Junjie; Shi, Jinjin
【作者单位】School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China
【年，卷(期)：页码】2022, 8: eabn3917
【关键词】oral drug delivery; biomimetic; intestinal mucus barrier; colorectal cancer
【摘要】Oral drug delivery systems have great potential to treat colorectal cancer (CRC). However, the drug delivery efficiency is restricted by limited CRC related intestine positioning and dense mucus barrier. Herein, we presenta biological chemotaxis-guided self-thermophoretic nanoplatform facilitates precise intestinal positioning and autonomous mucus penetration. The nanoplatform introducesasymmetric platinum sprayed mesoporous silica to achieve autonomous movement in intestinal mucus. Furthermore, inspired by the intense interaction between pathogenic microbes and CRC, the nanoplatform is camouflagedby Staphylococcus aureusmembrane (SAM)to precisely anchor in CRC related intestine. Owing to 4.3-fold higher biological chemotactic anchoring of CRC related intestine and 14.6-fold higher autonomous mucus penetration performance, the nanoplatform vastly improves the oral bioavailability of cisplatin, leading to a tumor inhibition rate of 99.1% on orthotopic CRC-bearing mice. Taken together, the exquisitely designed nanoplatform to overcome multiplephysiological barriers provides a new horizon for the development of oral drug deliverysystems.