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    杜 斌

    2021-08-31 杜斌  点击:[]

     


    博士,教授,博士生导师。河南省教学名师,河南省肿瘤重大疾病靶向治疗与诊断重点实验室副主任、河南省药学会药物分析专委会副主委、河南省生物物理学会理事,国际TOP期刊ACS Nano、Nano Letters及Biomaterials等特约审稿专家。主要研究方向:1、药物微载体转运系统的构建;2、疾病早期标志物检测系统研究。主持国家自然基金面上项目1项,参与国家纳米科技专项1项,国家自然基金项目4项,主持其他省部级项目8项,市科技局创新团队项目1项;河南省自然科学奖二等奖1项;发表学术论文60余篇,其中以第一或通讯作者,在国际权威期刊上发表SCI/EI收录论文40余篇,Small,Nanoscale等中科院JCR一区论文10余篇;授权国家发明专利3项。

    联系方式:dubin@zzu.edu.cn、电话:0371-67781891

    工作与教育经历:

    2010/12 - 至今,郑州大学,药学院,教授

    (期间2012/02 –2014/10,吉林大学,药学院,博士后)

    2003/12 –2010/11,郑州大学,药学院,副教授

    2007/09 - 2010/06,郑州大学,药物化学,博士

    2001/09 - 2004/06,郑州大学,分析化学,硕士

    1985/09 - 1989/06,河南大学,化学,学士

    社会兼职:

    • 河南省生物物理学会 理事

    • 河南省药学会药物分析专业委员会 副主

    荣誉称号及奖励:

    • 2019年 河南省高等学校教学名师

    • 2020年 河南省自然科学奖二等奖,第一

    专著与教材:

    • 杜斌(副主编),《药学论文写作》,人民卫生出版社,2021年

    • 杜斌(主编),《药物色谱分析的理论与应用》,郑州大学出版社,2018年

    主持或参加研究项目:

    1.国家自然科学基金委,81971741,双向“归巢式”pH/酶响应型释放的肿瘤化疗-免疫治疗纳米系统研究,2020/01-2023/12,55万元,进行,主持。

    2.国家自然科学基金面上项目,81273451,多机制治疗肿瘤光热控释长循环转运系统的研究,2013/01-2016/12,35万元,结题,参加。

    3.科技创新团队项目,121PCXTD521,纳米药物制剂的研制,2012/06-2015/06,80万元,结题,主持。

    4.河南省科技攻关项目,52110131,“铁蛋白笼”多模式成像肿瘤诊疗一体化纳米平台的构建,2015/01-2016/12,10万元,结题,主持。

    5.  河南省自然基金项目,182300410308,基于仿生分子特异性识别的乳腺癌靶向智能控释诊疗系统研究,2018/01-2019/12,10万元,结题,主持。

    6. 国家自然科学基金委-河南联合基金项目,U1804183,肿瘤“主动招募”式仿生纳米“特工”对乳腺癌的治疗研究,2019/01-2021/12,48万元,拟结题,参加。

    国家发明专利:

    1. 杜斌,朱玲,张振中,赵娅,王舒雨,赵芝兰,2-甲氧基雌二醇纳米混悬剂冻干粉及其制备方法,授权,ZL 2009 1 0065461.6

    2. 杜斌,韩淑萍,赵飞飞,苏相洁,王宇辉,一种近红外激光触发的复合纳米制剂的制备方法,公开,CN201510432200.9

    学术论文:

    1. Hanchun Yao, Xiaofang Guo, Huijuan Zhou, Jinjin Ren, Ying Li, Songchao Duan, Xiaobao Gong, Bin Du*. Mild acid-responsive “nanoenzyme capsule” remodeling of the tumor microenvironment to increase tumor penetration. ACS Appl. Mater. Interfaces 2020, 12, 20214-20227(一区)

    2. Bin Du, Qinghui Wang, Ying Yang, Qian Du, Ying Liu, Wanying Zhu, Tianguo Xu, Guopeng Shen, Hanchun Yao*, Lei Wang*. Biomacromolecules 2019, 20, 2873-2887(一区)

    3. Feifei Zhao, Jie Zhou, Xiangjie Su, Yuhui Wang, Xiaosa Yan, Shaona Jia, Bin Du*. A smart responsive dual aptamers-targeted bubble-generating nanosystem for cancer triplex therapy and ultrasound imaging. Small, 2017,1:1-13(一区)

    4. Xiangjie Su, Feifei Zhao, Yuhui Wang, Xiaosa Yan, Shaona Jia, Bin Du*. CuS as a gatekeeper of mesoporous upconversion nanoparticles-based drug controlled release system for tumor-targeted multimodal imaging and synergetic chemo- thermotherapy. Nanomedicine-Nanotechnology Biology and Medicine, 2017, 13(5):1761-1772(一区)

    5. Bin Du, Shuping Han, Hongyan Li, Feifei Zhao, Xiangji Su, Zhenzhong Zhang*. Multi-functional liposomes having radiofrequency-triggered release and magnetic resonance imaging for tumor multi-mechanism therapy. Nanoscale, 2015, 7: 5411-5426(一区)

    6. Bin Du, Shuping Han, Feifei Zhao, Kok Hwa Lim, Hongwei Xi, Xiangjie Su, Hanchun Yao*, Jie Zhou*. A smart upconversion-based light-triggered polymer for synergetic chemo-photodynamic therapy and dual-modal MR/UCL imaging. Nanomedicine-Nanotechnology Biology and Medicine, 2016, 12: 2071-2080(一区)

    7. Bin DuXiaohui CaoFeifei ZhaoXiangjie SuYuhui WangXiaosa YanShaona JiaJie Zhou*Hanchun Yao*. Multimodal imaging-guided, dual-targeted photothermal therapy for cancer. Journal of Materials Chemistry B, 2016, 4: 2038-2050(一区)

    8. Bin Du, iantian Qu, Zheng Chen, Xiaohui Cao, Shuping Han, Guopeng Shen*, Lei Wang. A novel restricted access material combined to molecularly imprinted polymers for selective solid-phase extraction and high performance liquid chromatography determination of 2-methoxyestradiol in plasma samples. Talanta, 2014, 129 : 465-472(一区)

    9. Bin Du, Tiantian Wang, Shuping Han, Xiaohui Cao, Tiantian Qu, Feifei Zhao, Guo Xinhong, Hanchun Yao*. Determination of 2-methoxyestradiol by chemiluminescence based on luminol-KMnO4-CdTe quantum dots system. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy201536 : 149-154 (二区)

    10. Bin Du, Ying Li, Xiaotian Li, Youmei A, Chengqun Chen, Zhenzhong Zhang*. Preparation, characterization and in vivo evaluation of 2-methoxyestradiol-loaded liposomesInternational Journal of Pharmaceutics, 2010, 384 : 140-147(二区)

    11. Bin Du, Li Pang, Hongyan Li, Sijia Ma, Yang Li, Xin Jia, Zhenzhong Zhang*. Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of indapamide enantiomers in rats. Journal of Chromatography B, 2013, 932: 88-91(二区)

    12. Bin Du, Li Pang, Yanhua Yang, Guopeng Shen, Zhenzhong Zhang*. Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of pioglitazone enantiomers in rats. Journal of Chromatography B, 2014, 951:143-148(二区)

    13. Bin Du, Hongyan Li, Jianwen Jin, Tiantian Wang, Yang Li, Guopeng Shen*, Xiaotian Li*. Chemiluminescence determination of streptomycin in pharmaceutical preparation and its application to pharmacokinetic study by a flow injection analysis assembly. Spectrochimica Acta A, 2013, 115 : 823-828 (二区)

    14. Bin Du, Shuyu Wang, Xiufang Shi, Chaofeng Zhang, Zhenzhong Zhang*. The effect of 2-methoxyestradiol liposome on growth inhibition, angiogenesis and expression of VEGF and Ki67 in mice bearing H22 hepatocellular carcinoma. Tumori, 2011, 97: 660-665

    15. Bin Du, Zhilan Zhao, Huibin Sun, Sijia Ma, Jianwen Jin, Zhenzhong Zhang*. Effects of 2-methoxyestradiol on proliferation, apoptosis and gene expression of cyclin B1 and c-Myc in esophageal carcinoma EC9706 cells. Cell Biochemistry and Function, 2012, 30: 158-165

    16. Guopeng Shen, Qingyu Wang, Qingqing Zhang, Huibin Sun, Ya Zhao, Zhenzhong Zhang*, Bin Du*. Tissue distribution of 2-methoxyestradiol nanosuspension in rats and its antitumor activity in C57BL/6 mice bearing lewis lung carcinoma. Drug Delivery, 2012, 19 : 327-333 (二区)

    17. Shuzhang Du, Ling Zhu, Bin Du*, Xiufang Shi, Zhenzhong Zhang*, Chaofeng Zhang. Pharmacokinetic evaluation and antitumor activity of 2-methoxyestradiol nanosuspension. Drug Development and Industrial Pharmacy, 2012, 38: 431-438

     

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