赵洪娟
郑州大学药学院直聘研究员。中原英才----河南省博士后创新人才。主持国家自然科学基金青年项目、中国博士后特别资助、中国博士后面上资助、河南省博士后创新项目、河南省科技攻关等项目。以第一/通讯（含共同）作者在Advanced Functional Materials（IF 19.0）、ACS NANO（IF 15.8）、 Bioactive Materials (IF 20.3)、Acta Pharmaceutica Sinica B（IF 14.6）、Journal of controlled release（IF 11.5）等国际知名SCI期刊发表多篇学术论文，申请发明专利7项。
联系方式：zhaohongjuan@zzu.edu.cn
工作与教育经历：
2022.01-至今，郑州大学，药学院药物分析系，直聘研究员
2017.09-2021.12，郑州大学，药物化学，博士
2011.09-2015.06，郑州大学，药学，学士
荣誉称号及奖励：中原英才----河南省博士后创新人才
专著与教材：赵洪娟（参编），《药物分析实验与指导》，郑州大学出版社，2025年
主持或参加研究项目：
1. 国家自然科学基金青年基金，82202318，在研，主持；
2. 中国博士后特别资助项目，2022TQ0310，在研，主持；
3. 中国博士后面上资助项目，2023M733258，在研，主持；
4. 中原博新项目，在研，主持。
5. 河南省科技攻关项目，242102311214，结项，主持。
6. 国家自然科学基金委员会, 联合基金项目, U1804183，结项，参与。
国家发明专利：
1. 赵洪娟；王蕾；李亚桐；牛梦亚；冯倩华；时海钰；宋庆龄；一种光谱活性物质清除功能胶束及其制备方法和应用；发明专利；CN 116139291 B
2. 赵洪娟; 王蕾; 王银珂; 郭雨欣; 李晴；一种还原响应性增敏肿瘤免疫化疗的纳米胶束的制备方法；发明专利；CN202510068300.1
3. 赵洪娟; 王蕾; 李晴; 王银珂; 郭雨欣; 王雅静; 孟迪；一种增强癌症免疫治疗的工程化细胞囊泡纳米疫苗的制备方法及其应用；发明专利；202510696146.2
4. 赵洪娟; 王蕾; 张楠; 姜倩倩; 傅璐思；一种光热抗菌的水凝胶敷料及其制备方法；发明专利；授权，202510011517.9
5. 王蕾；赵洪娟；郭雨欣；李晴；王银珂；孟迪；王雅静；一种增强肿瘤光热免疫联合治疗疗效的微生物制剂及其制备方法和应用；发明专利；202510547396.X
6. 王蕾；宋庆龄；巩爽；牛梦亚；赵荦；冯倩华；赵洪娟；韩璐；焦健楠；王芳芳；一种基于益生菌芽孢的纳米抗菌递药系统及其制备方法和应用；发明专利；授权，CN 116585449 B
7. 王蕾，宋庆龄，张云，张振中，高慧，王珂，郑翠霞，赵洪娟，冯倩华，张红岭，一种基于益生菌芽孢衣壳纳米材料与益生菌组合物的制备方法及应用，2021-8-17，中国，授权，CN202011426215.1
学术论文：
1. Hongjuan Zhao, Qingling Song, Cuixia Zheng, Beibei Zhao, Lixia Wu, Qianhua Feng, Zhenzhong Zhang* and Lei Wang*. Implantable Bio-Responsive Nanoarray Enhances Post-Surgical Immunotherapy by Activating Pyroptotis and Remodeling Tumor Microenvironment. Adv Funct Mater, 2020, 2005747. SCI 一区（中科院分区），IF：19.0.
2. Hongjuan Zhao, Beibei Zhao, Lixia Wu, Huifang Xiao, Kaili Ding, Cuixia Zheng, Qingling Song, Lingling Sun, Lei Wang* and Zhenzhong Zhang*. Amplified Cancer Immunotherapy of a Surface-Engineered Antigenic Microparticle Vaccine by Synergistically Modulating Tumor Microenvironment. ACS Nano, 2019, 13, 12553−12566. SCI 一区（中科院分区），IF：15.8.
3. Hongjuan Zhao, Di Meng, Yajing Wang, Yinke Wang, Qing Li, Yuxin Guo, Qingling Song*, Lei Wang*. A multifunctional hydrogel for obesity-associated tumor immunotherapy and postsurgical wound healing promotion. Bioactive Materials 57 (2026) 710–725. SCI 一区（中科院分区），IF：20.3.
4. Hongjuan Zhao, Yinke Wang, Yajing Wang, Di Meng, Qing Li, Yuxin Guo, Lei Wang* and Zhenzhong Zhang*. Redox-responsive nanodrug enhances cascaded chemo-immunotherapy via tandem chemoresistant microbiome depletion and efferocytosis blockade. Chemical Engineering Journal 523 (2025) 168657. SCI 一区（中科院分区），IF：13.2.
5. Hongjuan Zhao, Mengya Niu, Yuxin Guo, Qing Li, Yinke Wang, Qianqian Jiang, Qingling Song, Yi Zhang*, Lei Wang*. A lipid starvation strategy-synergized neutrophil activation for postoperative melanoma immunotherapy. Journal of Controlled Release 380 (2025) 860–874. SCI 一区（中科院分区），IF：11.5.
6. Mengya Niua, Yihan Pei, Tiantian Jin, Junxiu Li, Liming Bai, Cuixia Zheng, Qingling Song, Hongjuan Zhao*, Yun Zhang*, Lei Wang*. Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer. Acta Pharmaceutica Sinica B 2024;14(11):4977-4993. SCI 一区（中科院分区），IF：14.6.
7. Hongjuan Zhao, Yatong Li, Beibei Zhao, Cuixia Zheng, Mengya Niu, Qingling Song, Xinxin Liu, Qianhua Feng*, Zhenzhong Zhang*, Lei Wang*. Orchestrating antigen delivery and presentation efficiency in lymph node by nanoparticle shape for immune response. Acta Pharmaceutica Sinica B 2023;13(9):3892-3905. SCI 一区（中科院分区），IF：14.6.
8. Qianhua Feng, Ning Wang, Xueli Zhang, Yuying Mei, Rongkun Fu, Jing Chen, Xiaomin Yuan, Shuaiqi Yang, Zhenzhong Zhang*, Hongjuan Zhao*, Lei Wang*. Nanoparticle cluster depolymerizes and removes amyloid fibrils for Alzheimer’s disease treatment. Nano Today 48 (2023) 101756. SCI 二区（中科院分区），IF：10.9.
9. Hongjuan Zhao, Yatong Li, Haiyu Shi, Mengya Niu, Dan Li, Zhenzhong Zhang, Qianhua Feng*, Yi Zhang*, Lei Wang*. Prodrug nanoparticles potentiate tumor chemo-immunometabolic therapy by disturbing oxidative stress. Journal of Controlled Release 352 (2022) 909–919. SCI 一区（中科院分区），IF：11.5.
10. Hongjuan Zhao, Beibei Zhao, Li Li, Kaili Ding, Huifang Xiao, Cuixia Zheng, Lingling Sun, Zhenzhong Zhang*, and Lei Wang*. Biomimetic Decoy Inhibits Tumor Growth and Lung Metastasis by Reversing the Drawbacks of Sonodynamic Therapy. Advanced Healthcare Materials, 2019, 1901335. SCI 一区（中科院分区），IF：9.6.
11. Hongjuan Zhao, Li Li, Junli Zhang, Cuixia Zheng, Kaili Ding, Huifang Xiao, Lei Wang,* and Zhenzhong Zhang*. C−C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer. ACS Applied Materials & Interfaces, 2018, 10, 31124−31135. SCI 一区（中科院分区），IF：8.3.
12. Hongjuan Zhao, Li Li, Cuixia Zheng, Yongwei Hao, Mengya Niu, Yujie Hu, Junbiao Chang, Zhenzhong Zhang∗, and Lei Wang*. An intelligent dual stimuli-responsive photosensitizer delivery system with O2-supplying for efficient photodynamic therapy. Colloids and Surface B: Biointerfaces，167 (2018) 299-309. SCI 二区（中科院分区），IF：5.4.
13. Qingling Song, Hongjuan Zhao, Cuixia Zheng, Ke Wang, Hui Gao, Qianhua Feng, Hongling Zhang, Zhenzhong Zhang,* Yun Zhang,* and Lei Wang*. A Bioinspired Versatile Spore Coat Nanomaterial for Oral Probiotics Delivery. Adv Funct Mater, 2021, 2104994. SCI 一区（中科院分区），IF：19.9.
14. Qingling Song, Cuixia Zheng, Jiajia Jia, Hongjuan Zhao, Qianhua Feng, Hongling Zhang, Lei Wang,* Zhenzhong Zhang,* and Yun Zhang*A Probiotic Spore-Based Oral Autonomous Nanoparticles Generator for Cancer Therapy. Advanced Materials, 2019, 31, 1903793. SCI 一区（中科院分区），IF：32.1.
