Gold nanocages with dual modality for image-guided therapeutics.

【作者】 Shijin Bao, Shengnan Huang, Ying Liu, Yurong Hu*, Weiping Wang, a Mengfei Ji, Huili Li, Ning Xia Zhang, Chengzhi Song, Shaofeng Duan.

【期刊名】 Nanoscale

【影响因子】 2017年: 9. 7284

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, China.

【DOI】2017, 9, 7284 - 7296

【摘要】Numerous studies have demonstrated that microRNAs are very important in cancer development andprogression. However, the complex relationship between the size of microRNA delivery systems, cellularuptake, biodistribution and therapeutic efficiency remains unclear. Herein, we have successfully con-structed a series of differently-sized microRNA delivery systems, miR-26a-loaded, hyaluronic acid-modified, polyetherimide-conjugated PEGylated gold nanocage ternary nanocomplexes (PPHAuNCs-TNCs), which can be monitored optically by fluorescence and photoacoustic tomography imaging. Weevaluated the effect of the particle size on the cellular uptake and biodistribution in the BEL-7402 cell linein vitro and in the subcutaneous and orthotopic hepatocellular carcinoma (HCC) mouse models. Ourfindings showed that the cellular uptake and biodistribution were optimal for cancer therapy with thePPHAuNCs-30-TNCs (30 nm AuNCs in edge length) in comparison with their 50 nm and 70 nm counter-parts. PPHAuNCs-30-TNCs could accumulate in the liver for a longer time in an orthotopic mouse modelof HCC than that in normal mice and could considerably restrain tumor growth in an orthotopic HCCmouse model under near-infrared radiation. This study may provide insightful information for developingnovel non-viral microRNA vectors, and PPHAuNCs-30-TNCs have great potential for application in tumordiagnosis and cancer therapy in the future.