Epigallocatechin gallate based magnetic gold nanoshells nanoplatform for cancer theranostic applications.

【作者】Yin, Yanyan; Cui, Lingling; Yan, Fulin; Zhang, Zhenzhong; Li, Wenjie; Wang, Lei

【期刊名】JOURNAL OF MATERIALS CHEMISTRY B

【影响因子】 2017年: 4.872

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2017, 5( 3) : 454-463

【关键词】 PHOTOTHERMAL THERAPY; IN-VIVO; HYBRID NANOPARTICLES; PROSTATE-CANCER; DELIVERY-SYSTEM; GREEN SYNTHESIS; DRUG-DELIVERY; TUMOR; CELLS; NANOCLUSTERS

【摘要】Recently, gold nanomaterials and iron oxide nanoparticles (NPs) have attracted much attention due to their unique physical, chemical and biological properties. In this study, polyethyleneimine (PEI)-modified Fe3O4 NPs (inner cores) were first prepared, and then gold shells (AuNSs) were innovatively formed on the cores using epigallocatechin gallate (EGCG) as the reducing agent to obtain Fe3O4-PEI@AuNSs-EGCG core-shell NPs. After PEG modification, the Fe3O4-PEI@AuNSs-EGCG/PEG nanoplatform was completed. This highly integrated nanoplatform has shown remarkable biostability, rapid cellular uptake, and excellent in vitro and in vivo anti-tumour activity. Moreover, this nanoplatform can also be used as a magnetic resonance (MR)/X-ray dual-mode imaging agent. In all, the results of this study showed that Fe3O4-PEI@AuNSs-EGCG/PEG is a promising, potentially effective, theranostic nanoplatform for tumour treatment.theranostics..

【全文链接】

http://pubs.rsc.org/en/Content/ArticleLanding/2017/TB/C6TB02408D#!divAbstract