Two-Way Cruise Nanosatellite Promotes Metastasis Inhibition byImmunochemotherapy

【作者】Du,Bin; Wang,Qinghui; Yang,Ying; Du,Qian; Liu,Ying; Zhu,Wanying;Xu,Tianguo; Shen,Guopeng; Yao,Hanchun; Wang, Lei

【期刊名】Biomacromolecules

【影响因子】 2018年:5.667

【作者单位】School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2019, 20, 2873−2887

【摘要】Currently, immunochemotherapy based on tumorassociated macrophages (TAMs) is mainly used for elimination ofM2 macrophages. However, these methods cannot make full use ofthe positive immune-modulatory effects of macrophages. This studyexplores a two-way cruise strategy for combining immunotherapybased on TAM phenotype reversal with classical chemotherapy, thenanosatellites (DOX@HFn-PGZL@Res) are proposed to accuratelydeliver the chemotherapeutic agents and immune activators to theirrespective target cells. When the delivery system is recruited to tumormicroenvironment, the nanosatellites are separated into DOX@HFnand Res@GZL nanoparticles, which can enter cancer cells and M2-TAMs, respectively. The data show thatDOX@HFn-PGZL@Ressuccessfully re-educate M2 to M1 macrophages, resulting in anactivated immune response and inhibition of tumor invasion andmetastasis. In general, this work describes a two-way homing nanoplatform for the integration of immunotherapy andchemotherapy, which provides a new idea for the “attack-defense” integrated treatment of tumor.

【全文链接】

https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.9b00788