A traceable nanoplatform for enhanced chemo-photodynamic therapy by reducing oxygen consumption
【作者】 Hanchun Yao, Suge Zhang, Xiaofang Guo, Ying Li, Jinjin Ren, Huijuan Zhou, Bin Du, Jie Zhou
【期刊名】Nanomedicine: Nanotechnology, Biology, and Medicine
【影响因子】 2019年: 5.57
【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China
【年，卷(期)：页码】2019, 20: 101978-101989
【关键词】 Tumor hypoxia; Metformin; Carbon dots; Traceable; Enhanced chemo-photodynamic therapy
【摘要】Tumor hypoxia impedes the efficiencies of oxygen-dependent photodynamic therapy (PDT) and chemotherapy. Herein, we design a traceable nanoplatform (DOX/Met/BSA-HA-CDs) by reducing oxygen (O 2 ) consumption to overcome the hypoxia-caused cancer therapy. Carbon dots (CDs) are used not only as a PDT agent but also applied for in vivo traceable imaging. Metformin (Met), a potent antihyperglycemic agent, to improve tumor oxygenation and enhance the efficiencies of hypoxia-caused cancer therapy. In the hypoxic tumor microenvironment, Met was released more rapidly than DOX, which is advantageous for improving hypoxic cancer to exert a better therapeutic efficiency. Ex vivo immunofluorescence staining revealed that the DOX/Met/BSA-HA-CDs nanoparticles greatly reduce O 2 consumption in tumor site. Followed by in vivo synergistic treatment achieved considerably enhanced cancer therapeutic efficiency. This system holds great clinical promise as a traceable imaging approach to guide the improvement of PDT and chemotherapy efficiencies through utilizing a simple, safe method improved hypoxic tumor microenvironment.
【全文链接】
https://doi.org/10.1016/j.nano.2019.03.001
