Cancer Cell Membrane-BiomimeticNanoplatform forEnhanced Sonodynamic Therapy on Breast Cancer via Autophagy Regulation Strategy

【作者】 Qianhua Feng, Xuemei Yang, Yutong Hao, Ning Wang, Xuebing Feng, Lin Hou,Zhenzhong Zhang

【期刊名】 ACS Appl. Mater. Interfaces

【影响因子】 2018年:8.456

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, China

【年，卷(期)：页码】2019, 11,36,: 32729-32738

【关键词】 sonodynamic therapy; hollow mesoporoustitanium dioxide; autophagy regulation; biomimetic; homologous targeting

【摘要】Autophagy was considered as a double-edged sword that might cooperate, aggravate or antagonize apoptosis. We found that thesonodynamic therapy (SDT) in low dosage induced autophagy might function as a survival pathwayfor breast cancer and exhibited resistance to SDT mediated apoptosis. In this sense, it was highly desired to enhance SDT via autophagy regulation strategy. Herein, we reported a biomimetic nanoplatform based on hollow mesoporoustitanium dioxidenanoparticles (HMTNPs) by autophagy inhibitor (hydroxychloroquine sulphate, HCQ) loading and cancer cell membrane (CCM) coating. Owing to the biomimetic surface functionalization, the CCM-HMTNPs/HCQ could escape from macrophage phagocytosis, actively recognize and “home” to tumor by homologous targeting ability. Afterwards, the released HCQ in response to ultrasound stimulus was capable of blocking autophagic flux and cutting off the nutrients supply derived from the damaged organelles, which was anticipated to abrogate the cells’ resistance to SDT. Meanwhile, the vessel normalization effect of HCQ alleviated the tumor hypoxia, which was bound to enhance the oxygen-dependentHMTNPs mediated SDT treatment. Based on the above findings, it was undoubtedly logical that CCM-HMTNPs/HCQ would sensitize breast cancer cells to SDT via autophagy regulation strategy, which held a great promise in cancer treatment.

【全文链接】https://pubs_acs.gg363.site/doi/abs/10.1021/acsami.9b10948