Medical education of ZZU could date back to the establishment of National No.5 Sun Yat-sen University in 1928, whose medicine discipline became an independent institution, and was renamed “Henan Medical College” in 1952, hence breaking new ground for Henan modern medical education. The former ZZU, the first comprehensive university established by new China in 1956, was approved to enter National “211 Project” list in 1996. Zhengzhou University of Technology (ZUT), a crucial national university founded in 1963, was under the direct leadership of the former Ministry of Chemical Industry. A new ZZU was born in July 2000 when the former ZZU, ZUT and Henan Medical University (HMU) merged into one. A large number of distinguished scholars and experts have come to teach or work at this university, such as Prof. Ji Wenfu, an educator, historian and philosopher, Prof. Huo Bingquan, a physicist, Prof. Hou Debang, a chemist, Academician Zhong Xiangchong from Chinese Academy of Sciences, an expert in refractory, Prof. Sun Guoliang, an expert in civil engineering, Prof. Dong Minsheng, an expert in otolaryngology, Prof. Shen Qiong, the founder of the esophageal cytology, and Prof. Su Shouzhi, an expert in the human parasitology.

The 10th Affiliated Hospital of Zhengzhou University, which carries clinical medicine, is a three-grade hospital. One of the affiliated hospitals and the people's hospital is the Ministry of the Provincial Department to co-establish a hospital, with 36 national-level clinical key specialties and 139 provincial medical key (cultivation) disciplines, which has gathered the highest quality medical resources in Henan Province. The number of open beds is over 3.0 million, and the annual outpatient volume is 181.3 million (times).