Multi-functional liposomes having radiofrequency-triggered release and magnetic resonance imaging for tumor multi-mechanism therapy.

【作者】Bin Du, Shuping Han, Hongyan Li, Feifei Zhao, Xiangji Su, Zhenzhong Zhang*

【期刊名】Nanoscle

【影响因子】 2017年: 7.760

【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

【年，卷(期)：页码】2015, 7: 5411-5426

【关键词】chemo-hyperthermia-bio therapy;ultrasound imaging; photothermal responsive

【摘要】Recently, tumor-targeting drug carriers, MRI, optical imaging, thermal therapy etc., have become popular in the field of cancer research. The present study reports a novel multi-functional liposome for cancer theranostics. A dual targeted drug delivery with radiofrequency-triggered drug release and imaging based on the magnetic field influence was used advantageously for tumor multi-mechanism therapy. In this system, the surface of fullerene (C60) was decorated with iron oxide nanoparticles, and PEGylation formed a hybrid nanosystem (C60-Fe3O4-PEG(2000). Thermosensitive liposomes (DPPC) with DSPE-PEG(2000)- folate wrapped up the hybrid nanosystem and docetaxel (DTX), which were designed to combine features of biological and physical (magnetic) drug targeting for fullerene radiofrequency-triggered drug release. The magnetic liposomes not only served as powerful tumor diagnostic magnetic resonance imaging (MRI) contrast agents, but also as powerful agents for photothermal ablation of tumors. Furthermore, a remarkable thermal therapy combined chemotherapy multi-functional liposome nanoplatform converted radiofrequency energy into thermal energy to release drugs from thermosensitive liposomes, which was also observed during both in vitro and in vivo treatment. The multi-functional liposomes could selectively kill cancer cells in highly localized regions via their excellent active tumor targeting and magnetic targeted abilities.

【全文链接】www.rsc.org/nanoscale