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    王蕾等Radiofrequency-Triggered Tumor-Targeting Delivery System for Theranostics Application.

    2017-10-19   点击:[]

    Radiofrequency-Triggered Tumor-Targeting Delivery System for Theranostics Application.

    【作者】Wang, Lei; Zhang, Panpan; Shi, Jinjin; Hao, Yongwei; Meng, Dehui; Zhao, Yalin; Yin, Yanyan; Li, Dong; Chang, Junbiao; Zhang, Zhenzhong

    【期刊名】 ACS Applied Materials & Interfaces

    【影响因子】 2015: 7.145

    【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China

    【年,卷():页码】2015, 7(10): 5736-5747

    【关键词】 thermosensitive magnetoliposomes; gold nanoshells; dual-mode MR/X-ray imaging controlled release; chemo-hyperthermia therapy

    【摘要】In this study, a new type of magnetic tuniot-targeting P-B-Gylated gold nanoshell drug delivery system (DOX-TSMLs-AuNSs-PEG) based on doxorubicin-loaded thermosensitive magnetoliposomes Was successfully obtaitied. The reversephase evaporation method was used to construct the magnetoliposorneS, and then gold nanoShells were coated on the Surface Of it. The DOX-TSMLs-AuNSs-PEG delivery system was synthesized after SH-PEG(2000) modification. This rimItifunction system was combined with a variety of functions, such as radiofrequenty-triggered release, cherno-hyperthermia therapy, and dual-Mode magnetic resonance/X-ray imaging. Importantly, the DOX-TSMLs-AUNSs-PEG Complex was found to escape from endosomes after cellular uptake by radiofrequency-induced endosome disruption before lysosornal degradation. All results in vitro and in vivo indicated that DOX=TSMLs,AuNSs-PBG is a promising effective drug delivery system for diagnosis and treatment of tumors.

    【全文链接】

    http://pubs.acs.org/doi/abs/10.1021/am507898z


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