Radiofrequency-Triggered Tumor-Targeting Delivery System for Theranostics Application.
【作者】Wang, Lei; Zhang, Panpan; Shi, Jinjin; Hao, Yongwei; Meng, Dehui; Zhao, Yalin; Yin, Yanyan; Li, Dong; Chang, Junbiao; Zhang, Zhenzhong
【期刊名】 ACS Applied Materials & Interfaces
【影响因子】 2015年: 7.145
【作者单位】 School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China
【年,卷(期):页码】2015, 7(10): 5736-5747
【关键词】 thermosensitive magnetoliposomes; gold nanoshells; dual-mode MR/X-ray imaging controlled release; chemo-hyperthermia therapy
【摘要】In this study, a new type of magnetic tuniot-targeting P-B-Gylated gold nanoshell drug delivery system (DOX-TSMLs-AuNSs-PEG) based on doxorubicin-loaded thermosensitive magnetoliposomes Was successfully obtaitied. The reversephase evaporation method was used to construct the magnetoliposorneS, and then gold nanoShells were coated on the Surface Of it. The DOX-TSMLs-AuNSs-PEG delivery system was synthesized after SH-PEG(2000) modification. This rimItifunction system was combined with a variety of functions, such as radiofrequenty-triggered release, cherno-hyperthermia therapy, and dual-Mode magnetic resonance/X-ray imaging. Importantly, the DOX-TSMLs-AUNSs-PEG Complex was found to escape from endosomes after cellular uptake by radiofrequency-induced endosome disruption before lysosornal degradation. All results in vitro and in vivo indicated that DOX=TSMLs,AuNSs-PBG is a promising effective drug delivery system for diagnosis and treatment of tumors.
【全文链接】
http://pubs.acs.org/doi/abs/10.1021/am507898z