The origins of medical education at Zhengzhou University can be traced back to 1928 with the establishment of Henan Sun Yat-sen University's medical program, representing the genesis of higher medical education in Henan Province. In 1952, the medical school gained independent status as Henan Medical College, and further evolved into Henan Medical University in 1984. In a landmark merger in 2000, the institution became an integral part of the newly established Zhengzhou University. Building upon this rich legacy, the School of Medicine at Zhengzhou University was founded in 2018 and, in 2022, transitioned into the present-day Henan Medical College, Zhengzhou University.

The College offers a comprehensive range of 13 undergraduate majors, spanning fields such as Basic Medicine and Clinical Medicine. Notably, Clinical Medicine has been recognized as a National First-Class Major. Furthermore, Henan Medical College provides advanced training through five First-Level Doctoral Programs, eight First-Level Master's Degree Programs, five Professional Master's Degree Programs, and five Postdoctoral Research Stations. The college shoulders the critical responsibility of training nearly all Western medicine doctoral candidates and over 50% of master's candidates within Henan Province. Several disciplines have achieved international prominence, ranking within the top 1% globally according to Essential Science Indicators (ESI). The college exhibits a formidable research profile, evidenced by its involvement in numerous national-level projects and a wealth of significant research outcomes.

Henan Medical College is supported by a robust network of 13 affiliated hospitals, boasting an impressive array of 54 National Key Clinical Specialties, seven National Regional Medical Centers, and 290 Provincial Key (Cultivation) Medical Disciplines. With over 40,000 beds and an annual outpatient volume exceeding 25 million, these institutions provide a comprehensive platform for clinical training and patient care.

In alignment with international standards, the College has developed cutting-edge infrastructure, including foundational research platforms, translational medicine facilities, and experimental animal centers, equipped with laboratories and equipment meeting leading international benchmarks. Emphasizing both fundamental research and the effective translation of scientific discoveries into practical applications, Henan Medical College fosters a vibrant research ecosystem. A new, expansive campus is currently under construction within the Zhengzhou Airport Economy Zone. Spanning an area of 2,400 mu (1.6 million square meters), this state-of-the-art facility is envisioned as an international, modern, and intelligent campus with distinctive features tailored to medical education. Upon completion, it will significantly enhance the college's teaching and research capacity.

In pursuit of a global vision, Henan Medical College actively engages in extensive international collaborations, establishing robust partnerships with numerous prestigious universities and research institutions worldwide. This commitment to internationalization is a hallmark of the college's educational approach.

Henan Medical College, Zhengzhou University embraces the ambitious mission of advancing its medical disciplines to world-class standards, fostering internationalization, and cultivating exceptionally talented medical professionals. The College is steadfast in its commitment to becoming a nationally leading and internationally renowned institution for medical education and research.